Uterine Gland

Embryology - 16 Apr 2024        Expand to Translate
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Introduction

Uterine gland secretory phase

The uterine gland or endometrial gland is a simple tubular gland formed by invagination of the uterine endometrium. The uterine epithelium is described as a columnar epithelium of ciliated cells and secretory cells.

The glands extend into the underlying thick vascular stromal layer. The glands line the uterus body and change in appearance and secretion during the menstrual cycle. The glands secretions function to provide the initial nutritional support of the conceptus and may have a role in maintaining adhesion.

Some Recent Findings

WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development. "The WNTs are secreted proteins that control essential developmental processes, such as embryonic patterning, cell growth, migration, and differentiation. In mice, three members of the Wnt gene family (Wnt4, Wnt5a, and Wnt7a) have been studied extensively in the female reproductive tract. The present study determined effects of postnatal day and exposure to diethylstilbestrol (DES) on Wnt and Fzd gene expression in the mouse uterus as well as the biological role of Wnt11 in postnatal mouse uterine development and function." Developmental Signals - Wnt

More recent papers

This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Uterine Gland <pubmed limit=5>Uterine Gland</pubmed>

Uterine Gland Histology During the Menstrual Cycle

	Uterine gland proliferative phase	Uterine gland secretory phase

Menstrual Cycle Histology

The different stages of the menstrual cycle can be monitored by the cellular appearance of vaginal smears Menstrual Cycle - Histology.

A more invasive technique is dilate and curettage (DnC), which allows sampling of the functional layer of the uterine endometrium Menstrual Cycle - Histology.

Decidualization

Decidualization is the process of converting endometrial stromal cells into decimal cells and requires at least 8–10 days of hormone stimulation.

• initiated during the mid-secretory phase of the menstrual cycle
• in response to elevated progesterone levels
• acts mainly through progesterone receptor (PR) PR-A (other isoform is PR-B)

Molecular

PMID: 21546446 Prokineticin 1 (PROK1) signalling via prokineticin receptor 1 (PROKR1) regulates Dickkopf 1 (DKK1) expression, a negative regulator of canonical Wnt signaling.

Links: Placenta - Maternal Decidua

Histiotrophic Nutrition

Term used to describe in early placenta development the intital transfer of nutrition from maternal to embryo (histiotrophic nutrition) compared to later blood-borne nutrition (hemotrophic nutrition). Histotroph is the nutritional material accumulated in spaces between the maternal and fetal tissues, derived from the maternal endometrium and the uterine glands. This nutritional material is absorbed by phagocytosis initially by blastocyst trophectoderm and then by trophoblast of the placenta. in later placental development nutrition is by the exchange of blood-borne materials between the maternal and fetal circulations, hemotrophic nutrition.

References

Books

• Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Walker HK, Hall WD, Hurst JW, editors. Boston: Butterworths; 1990. Birth Control | Figure 174.1 A 28-day menstrual cycle. Not all cycles are 28 days long. It is the phase before ovulation that varies in length.
• Endocrinology: An Integrated Approach. Nussey S, Whitehead S. Oxford: BIOS Scientific Publishers; 2001. Box 6.42 The human menstrual cycle | Box 6.43 Feedback control of the hypothalamo-pituitary-ovarian axis

Reviews

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Articles

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Search Pubmed

Search Pubmed Now: Uterine Gland | Uterine Gland Secretion | Endometrial Gland

Additional Images

• 

  Immunohistochemical staining human endometrium for NAPE-PLD

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

• Women’s Health Queensland Wide - Understanding Your Menstrual Cycle

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Cite this page: Hill, M.A. (2024, April 16) Embryology Uterine Gland. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Uterine_Gland

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G