User talk:Z5016784

A summary of two research articles based on fertilization and in vito fertilization

The success rate of IVF treatment is typically determined by clinical implantation and interplay of clinical and nonclinical variables such as endometrial receptivity, ovulation induction protocols, patient’s age, etiology of infertility and gamete to embryo quality. Embryo grading prior to the embryo transfer is a widely researched topic, however the current embryo grading systems don’t support enough research and new reliable parameters are needed to be found.

One of these parameters are predicting IVF outcomes based on the thickness of the Zona Pellucida during fertilisation. Two clinical evidence are in support of this parameter. Evidence has shown that the implantation rates of human embryos correlate with the Zona Pellucida thickness ranging from 10-29%. Also adverse influences of prolonged embryo culture conditions in vito, that are manifested in the thickening and hardening of the Zona Pellucida, is leading to failure of up to 75% of IVF embryo hatching due to micro assisted fertilization techniques such as zona thinning and hatching.

Throughout other research conducted, there has shown a strong influence of Zona Pellucida thickness of the transferred embryos on clinical IVF outcomes. However certain research has also shown that Zona Pellucida thickness can be a reliable indicator for predicting the success of in vito fertilisation. The test conducted by Anette Gabrielsen and others, was performed on 141 women to shown if there is any correlation between the thickness of the Zona Pellucida of embryos during intracytoplasmic sperm injection (ICSI) treatment cycles. The result was the thickness of the Zona Pellucida shows a strong correlation with the clinical outcomes following IVF treatment, Indicating Zona Pellucida thickness can be a reliable indicator for determining the outcome of IVF treatment