User talk:Z3417753: Difference between revisions
From Embryology
No edit summary |
No edit summary |
||
| Line 8: | Line 8: | ||
<pubmed>23227157</pubmed> | <pubmed>23227157</pubmed> | ||
* Currently there are no effective treatments for children suffering with advanced anatomical disorders of the trachea. | |||
* An example of such a disorder is congenital tracheal stenosis, characterised by the presence of complete tracheal rings and stenosis of the larger airways.<ref name=PMID22381446><pubmed>22381446</pubmed></ref> | |||
* Children suffering with such congenital abnormalities often require constant hospitalisation with slide tracheoplasty being the preferred choice of treatment, however it is very common for patients to develop recurrent stenoses.<ref name=PMID15573072><pubmed>15573072</pubmed></ref> | |||
* This is often a result of stent erosion<ref name=PMID11053808><pubmed>11053808</pubmed></ref>, ultimately leading to death or the ability of the trachea to undergo somatic growth.<ref name=PMID22381446><pubmed>22381446</pubmed></ref> | |||
* Due to the severity of these conditions, they are considered fatal and once detected prenatally, the pregnancies are often terminated.<ref name=PMID21860060><pubmed>21860060</pubmed></ref> | |||
* In the past few years, there has been an increased use of tissue-engineered structures made from stem cells within clinical settings. | |||
* Benefits of stem cell-based tissue engineering procedures arise from the notion that remodeling of the native stroma would result in a lack of immunosuppression due to the similarity of the local tissue. | |||
* A case was reported where a successful stem cell-based tracheal replacement procedure was performed on a 26-year-old patient with end-stage airway disease.<ref name=PMID19022496><pubmed>19022496</pubmed></ref> | |||
* Whilst stem cell-based tracheal grafts have been successful with positive short-term outcomes, little evidence exists regarding the long-term effects of the grafts, specifically on children. | |||
* This study reports a 2-year follow-up of the first paediatric stem cell-based tracheal replacement, with the notion in mind that ideal results following the procedure are: | |||
** Normal airway and lung function | |||
** Appropriate somatic growth | |||
** Increased quality of life | |||
** Elimination of the need for continuous hospitalisation and the constant advent of surgical procedures. | |||
Revision as of 19:45, 27 October 2014
<pubmed>25084016</pubmed>
<pubmed>23227157</pubmed>
- Currently there are no effective treatments for children suffering with advanced anatomical disorders of the trachea.
- An example of such a disorder is congenital tracheal stenosis, characterised by the presence of complete tracheal rings and stenosis of the larger airways.[1]
- Children suffering with such congenital abnormalities often require constant hospitalisation with slide tracheoplasty being the preferred choice of treatment, however it is very common for patients to develop recurrent stenoses.[2]
- This is often a result of stent erosion[3], ultimately leading to death or the ability of the trachea to undergo somatic growth.[1]
- Due to the severity of these conditions, they are considered fatal and once detected prenatally, the pregnancies are often terminated.[4]
- In the past few years, there has been an increased use of tissue-engineered structures made from stem cells within clinical settings.
- Benefits of stem cell-based tissue engineering procedures arise from the notion that remodeling of the native stroma would result in a lack of immunosuppression due to the similarity of the local tissue.
- A case was reported where a successful stem cell-based tracheal replacement procedure was performed on a 26-year-old patient with end-stage airway disease.[5]
- Whilst stem cell-based tracheal grafts have been successful with positive short-term outcomes, little evidence exists regarding the long-term effects of the grafts, specifically on children.
- This study reports a 2-year follow-up of the first paediatric stem cell-based tracheal replacement, with the notion in mind that ideal results following the procedure are:
- Normal airway and lung function
- Appropriate somatic growth
- Increased quality of life
- Elimination of the need for continuous hospitalisation and the constant advent of surgical procedures.
