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Adrenal Gland and Neural Crest Cells

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Reference List

Walls ML & Hart RJ. (2018). In vitro maturation. Best Pract Res Clin Obstet Gynaecol , , . PMID: 30056110 DOI.

In vitro maturation recent article [1]

Neuropore cell shape changes.png

Neuropore cell shape changes[2]

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  1. Walls ML & Hart RJ. (2018). In vitro maturation. Best Pract Res Clin Obstet Gynaecol , , . PMID: 30056110 DOI.
  2. Shinotsuka N, Yamaguchi Y, Nakazato K, Matsumoto Y, Mochizuki A & Miura M. (2018). Caspases and matrix metalloproteases facilitate collective behavior of non-neural ectoderm after hindbrain neuropore closure. BMC Dev. Biol. , 18, 17. PMID: 30064364 DOI.



History of research is short, notes a few important researchers, lacks when melanocytes were connected to neural crest derivatives. It also lacks the knowledge of the role melanocytes play in human physiology and how that has changed, connection to Vitamin D synthesis and the history of the role melanocytes play in pathology could also be added.

Tissue Organ Structure and Function - Skin is completely missing, no images or text to be seen. Ear is well explained both in writing and images, understanding of chemical mediation in the adult has been elucidated, no reference to physiological role of the ear and how it achieves it, it would not have to be long. Figure 2 refers to Wv/Wv mutant, what is a Wv/Wv mutant? There is no explanation of this mutant model, whether it is in humans or animals, or why it is important etc. Eyes section notes the combined role of neural-crest derived cells and neuroepithelium of optic cup, explains the layers of the eye nicely within the associated image of Figure 4, which has been correctly formatted and cited. The heart section simply shows an image of a cardiac melanocyte, there should be more here. The CNS topic is short, but it does note the understanding of a role of melanocytes in CNS, but nothing more about how neural crest cells help with giving melanocytes to the CNS, the image is a nice overview of the skull and layers of the scalp.

Embryonic origins, Developmental time course and Molecular Mechanisms / Factors / Genes are all blank, with no images to be seen.

Reference to a mouse model can be seen in the Animal models section, are there other models in other species of mouse mutant that can observe melanocyte embryology? Mention of the melanoma model of genetically-engineered mice is good, but how does it relate to neural crest abnormality?

Current Research explains 2 new systems to observe melanocytes, this section could show findings and how they're important - could be longer. Abnormalities listed are short, some missing entirely, more focus on which are more common could be noted due to the vast nature of melanocytes. Glossary is nice but incomplete, and there are a sufficient number of references.