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== Lab 3 Assessment ==
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| [mailto:m.hill@unsw.edu.au Mark Hill] 31 August 2016 - Lab 3 Assessment Quiz - [[Lecture_-_Mesoderm_Development|Mesoderm]] and [[Lecture_-_Ectoderm_Development|Ectoderm]] development. All correct, well done!
| Assessment 5/5
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==Lab 4 Assessment==
==Lab 4 Assessment==

Revision as of 19:18, 31 August 2016

Student Information (expand to read)  
Individual Assessments
Mark Hill.jpg

Please leave this template on top of your student page as I will add your assessment items here.

Beginning your online work - Working Online in this course

  1. Make your own page.
    1. Log-in to the embryology website using your student ID and Zpass.
    2. Click your student number (shown in red at the top right of the screen following log-in)
    3. Create page using the tab at the top of the page, and save.
  2. Add the following to the top of your page exactly as shown - {{ANAT2341Student2016}}
  3. How would you identify your Type in a group and add to your page.
  4. What was the most interesting thing you learnt in the fertilisation lecture?


If you have done the above correctly your ZID should be blue and not red on this page link - ANAT2341 2016 Students.


Here is the example page I made in Lab 1 Student Page. With a few more explanatory notes.

Click here to email Dr Mark Hill

Editing Links: Editing Basics | Images | Tables | Referencing | Journal Searches | Copyright | Font Colours | Virtual Slide Permalink | My Preferences | One Page Wiki Card | Printing | Movies | Language Translation | Student Movies | Using OpenOffice | Internet Browsers | Moodle | Navigation/Contribution | Term Link | Short URLs | 2018 Test Student
Lab 1 Assessment - Researching a Topic
In the lab I showed you how to find the PubMed reference database and search it using a topic word. Lab 1 assessment will be for you to use this to find a research reference on "fertilization" and write a brief summary of the main finding of the paper.
  1. Add a new Sub-heading "Lab 1 Assessment" (without the quotes).
  2. Search the database for a reference on "fertilisation" published in the last 5 years.
    1. It must be a research article not a Review.
    2. The full paper must be available online, not just the abstract.
  3. Add a link to this reference using its PMID using this code <pubmed>XXXXX</pubmed> replacing the Xs with just the PMID number (no text).
  4. Under the reference write a short summary of the papers main findings.
    1. Only 1-2 paragraphs.
    2. Must not be a copy of the paper abstract.
  5. Save and you are done.

PubMed logo.gif

Lab 2 Assessment - Uploading an Image
  1. Upload a research image using the guide information below. The image uploaded for your individual assessment can relate to your project or from fertilisation to week 3 of development (upload only a single image).
  2. Add that image to your own individual page (see Images) including an image title and its reference link.
  3. No two students should upload the same image, check new images before you upload.
  4. No student can delete an image once uploaded, please contact me by email with the image address and I will delete (with no penalty, just glad to help out).


2016 Group Project Topic - Signaling in Development

OK you are now in a group

  1. Go to the blank group page and add a topic that interests you along with your student signature.
  2. No two groups can do the same topic, but at this stage the final topic has not yet been decided (next week).

Initially the topic can be as specific or as broad as you want.


Chicken embryo E-cad and P-cad gastrulation.png

Chicken embryo E-cad and P-cad gastrulation[1]

References

  1. <pubmed>27097030</pubmed>
Lab 4 Assessment - GIT Quiz

ANAT2341 Quiz Example | Category:Quiz | ANAT2341 Student 2015 Quiz Questions |

Design 4 quiz questions based upon gastrointestinal tract. Add the quiz to your own page under Lab 4 assessment and provide a sub-sub-heading on the topic of the quiz.

An example is shown below (open this page in view code or edit mode). Note that it is not just how you ask the question, but also how you explain the correct answer.

Lab 5 Assessment - Course Review
Complete the course review questionnaire and add the fact you have completed to your student page.
Lab 6 Assessment - Cleft Lip and Palate
  1. Identify a known genetic mutation that is associated with cleft lip or palate.
  2. Identify a recent research article on this gene.
  3. How does this mutation affect developmental signalling in normal development.
Lab 7 Assessment - Muscular Dystrophy
  1. What is/are the dystrophin mutation(s)?
  2. What is the function of dystrophin?
  3. What other tissues/organs are affected by this disorder?
  4. What therapies exist for DMD?
  5. What animal models are available for muscular dystrophy?
Lab 8 Assessment - Quiz
A brief quiz was held in the practical class on urogenital development.
Lab 9 Assessment - Peer Assessment
  • This will form part of your individual assessment for the course.
  • Each student should now look at each of the other Group projects in the class.
  • Next prepare a critical assessment (should include both positive and negative issues) of each project using the project group assessment criteria.
  • This assessment should be pasted without signature on the top of the specific project's discussion page. (minimum length 3-5 paragraphs/project)
  • This critical assessment should also be pasted on your own student page.
  • Each student should therefore have 5 separate reports pasted on their own page for this assessment item.
  • Length, quality and accuracy of your reports will be part of the overall mark for this assessment.
    • there will be a greater loading on this than simple question assessments.
Lab 10 Assessment - Stem Cells
As part of the assessment for this course, you will give a 15 minutes journal club presentation in Lab 10. For this you will in your current student group discuss a recent (published after 2011) original research article (not a review!) on stem cell biology or technology.
Lab 10 - Stem Cell Presentations 2016
Group Mark Assessor General Comments

Group 1: 15/20

Group 2: 19/20

Group 3: 20/20

Group 4: 19/20

Group 5: 16/20

Group 6: 16/20

The students put great effort in their presentation and we heard a nice variety of studies in stem cell biology and regenerative medicine today. The interaction after the presentation was great.

As general feedback I would like to advise students to:

  • Never discuss M&M as a separate section in journal clubs. I gave this advice prior to the lab, but still most groups did talk through the M&M section.
  • Do not use your slides as cheat sheets, avoid text on slides, know what messages you need to get across, use images to illustrate these
  • Engage with your slides. Talk through them. Point at panels. Gauge your audience’s understanding by making eye contact with them
  • Avoid using abbreviations. Most people do not readily understand these and will lose track
Lab 11 Assessment - Heart Development
Read the following recent review article on heart repair and from the reference list identify a cited research article and write a brief summary of the paper's main findings. Then describe how the original research result was used in the review article.

<pubmed>26932668</pubmed>Development

ANAT2341Lectures - Textbook chapters  
Lecture (Timetable) Textbook - The Developing Human Textbook - Larsen's Human Embryology
Embryology Introduction Introduction to the Developing Human
Fertilization First Week of Human Development Gametogenesis, Fertilization, and First Week
Week 1 and 2 Second Week of Human Development Second Week: Becoming Bilaminar and Fully Implanting
Week 3 Third Week of Human Development Third Week: Becoming Trilaminar and Establishing Body Axes
Mesoderm Fourth to Eighth Weeks of Human Development Fourth Week: Forming the Embryo
Ectoderm Nervous System Development of the Central Nervous System
Early Vascular Cardiovascular System Development of the Vasculature
Placenta Placenta and Fetal Membranes Development of the Vasculature
Endoderm - GIT Alimentary System Development of the Gastrointestinal Tract
Respiratory Respiratory System Development of the Respiratory System and Body Cavities
Head Pharyngeal Apparatus, Face, and Neck Development of the Pharyngeal Apparatus and Face
Neural Crest Nervous System Development of the Peripheral Nervous System
Musculoskeletal Muscular System Development of the Musculoskeletal System
Limb Development of Limbs Development of the Limbs
Renal Urogenital System Development of the Urinary System
Genital Urogenital System Development of the Urinary System
Stem Cells
Integumentary Integumentary System Development of the Skin and Its Derivatives
Endocrine Covered through various chapters (see also alternate text), read head and neck, neural crest and renal chapters.
Endocrinology Textbook - Chapter Titles  
Nussey S. and Whitehead S. Endocrinology: An Integrated Approach (2001) Oxford: BIOS Scientific Publishers; ISBN-10: 1-85996-252-1.

Full Table of Contents

Heart Cardiovascular System Development of the Heart
Sensory Development of Eyes and Ears Development of the Eyes
Fetal Fetal Period Fetal Development and the Fetus as Patient
Birth and Revision
Additional Textbook Content - The following concepts also form part of the theory material covered throughout the course.
  1. Principles and Mechanisms of Morphogenesis and Dysmorphogenesis
  2. Common Signaling Pathways Used During Development
  3. Human Birth Defect
ANAT2341 Course Timetable  
Week (Mon) Lecture 1 (Mon 1-2pm) Lecture 2 (Tue 3-4pm) Practical (Fri 1-3pm)
Week 2 (1 Aug) Introduction Fertilization Lab 1
Week 3 (8 Aug) Week 1 and 2 Week 3 Lab 2
Week 4 (15 Aug) Mesoderm Ectoderm Lab 3
Week 5 (22 Aug) Early Vascular Placenta Lab 4
Week 6 (29 Aug) Gastrointestinal Respiratory Lab 5
Week 7 (5 Sep) Head Neural Crest Lab 6
Week 8 (12 Sep) Musculoskeletal Limb Development Lab 7
Week 9 (19 Sep) Renal Genital Lab 8
Mid-semester break
Week 10 (3 Oct) Public Holiday Stem Cells Lab 9
Week 11 (10 Oct) Integumentary Endocrine Lab 10
Week 12 (17 Oct) Heart Sensory Lab 11
Week 13 (24 Oct) Fetal Birth and Revision Lab 12

ANAT2341 2016: Moodle page | ECHO360 | Textbooks | Students 2016 | Projects 2016

Lab Attendance

Z5015014 (talk) 14:35, 5 August 2016 (AEST)

Z5015014 (talk) 14:40, 12 August 2016 (AEST)

Z5015014 (talk) 13:13, 19 August 2016 (AEST)

Z5015014 (talk) 13:03, 26 August 2016 (AEST)


Week 1 Homework

Team Role

I studied the Belbin Team Roles in a previous course and identified myself as a Teamworker, which I still definitely agree with, but I'd probably also add that I have the tendencies of a Complete Finisher. In group assignments I always prefer not to take charge and rather to provide support by facilitating discussions and encouraging good communication within the group. In the past, I've often mediated between my real life friends when conflict happens so I'm comfortable in doing that for any group situation I find myself in. I'm also very indecisive as a person and I know this reflects into any group work that I do because I find it difficult if I have to lead or make choices for the rest of the team. I would also say that because I don't particularly look forward to group assignments in the first place, because I'd much rather complete a task by myself, I can sometimes be a Complete Finisher. I know that I hesitate having to rely on other people because I worry that they won't do something the way I would have chosen to do it.

Lecture 1: Fertilisation (2/8/16)

I've always found fertilisation to be an exciting and interesting topic. Even though I've studied it before in previous courses I still find it so fascinating just how much goes into the 'simple' union of a sperm and an egg cell. The way that so many processes and reactions and biological design come together to allow fertilisation to happen really amazes me. But I think the most interesting thing I heard in today's lecture was about the zona pellucida and the ZP2 protein, and how it's used as a signal to attract the sperm to bind to the ovum, and then modified to prevent polyspermy by stopping additional sperm from binding. I'd never learnt about this before so it was really interesting to understand the mechanism involved.

Mark Hill (talk) 12:36, 5 August 2016 (AEST) Very good. maybe a little to many sub-sub-sub- headings, this will get messy. I will discuss in today's lab online formatting etc.


Lab 1 Assessment

IVF culture medium affects post-natal weight in humans during the first 2 years of life.[1]
Sander H.M. Kleijkers, Aafke P.A. van Montfoort, Luc J.M. Smits, Wolfgang Viechtbauer, Tessa J. Roseboom, Ewka C.M. Nelissen, Edith Coonen, Josien G. Derhaag, Lobke Bastings, Inge E.L. Schreurs, Johannes L.H. Evers, and John C.M. Dumoulin

In this study, Kleijkers et al. investigated the relationship between the culture media used for embryos during the process of IVF and the subsequent development of the IVF children in early life. This followed on from previous research in which it was observed that the choice of culture medium had an impact on birthweight as well as development of the fetus during pregnancy. 1432 IVF treatments were initially involved and each was randomly allocated to either grow in Cook medium or Vitrolife medium. From this, 126 embryos from the Cook group and 168 embryos from the Vitrolife group were successfully birthed and used for further study. Kleijkers et al. contacted all of the parents two years after the initial birth for records of the postnatal weight, height, and head circumference of their child over the two year period. Statistical analysis and different analytical models were used to compare the collected data. It was observed that the weight of singletons whose embryos had been cultured in Cook medium was consistently lower than that of the Vitrolife group; this confirms that the effect of culture media on fetal growth, as had been previously researched, persists in early postnatal development. Kleijkers et al. propose that these results show the sensitivity of the human embryo to its environment, whether in vivo or in vitro. Hence because the chosen media for the embryo is the environment it grows in before implantation, the adaptation of this embryo to the media, possibly by epigenetic modification, is seen to have consequences for later development. This emphasises the need for further research into the growth media used for IVF treatment to ensure an optimal environment for the preimplantation growth of the embryo, and therefore both prenatal and postnatal development of an IVF child.
Mark Hill 18 August 2016 - You have added the citation correctly and written a good brief summary of the article findings. You also seem to have practiced using some of the Wiki formatting tools. So the very conditions of initial growth may have long-term developmental ramifications. You can see why research in this area is important. These days we have a reasonably large IVF cohort to begin to get some useful data.

You have to be careful though when commercial products are being compared. Cook medium | Vitrolife medium

Assessment 5/5


Lab 2 Assessment

Human Blastocyst with Decidualized Endometrial Stromal Cells.png
Human blastocyst attached to decidualized human endometrial stromal cells after 72 hours of co-culture.[2]


Mark Hill 29 August 2016 - All information Reference, Copyright and Student Image template correctly included with the file and referenced on your page here. Assessment 5/5


Lab 3 Assessment

Mark Hill 31 August 2016 - Lab 3 Assessment Quiz - Mesoderm and Ectoderm development. All correct, well done! Assessment 5/5


Lab 4 Assessment

Gastrointestinal Development Quiz

1 1. The splanchnic mesoderm does not contribute to:

epithelium
mesentery
blood vessels
smooth muscle

2 2. The correct order of blood supply for the foregut, midgut, and hindgut is:

inferior mesenteric artery, celiac artery, superior mesenteric artery
superior mesenteric artery, inferior mesenteric artery, celiac artery
celiac artery, superior mesenteric artery, inferior mesenteric artery
celiac artery, inferior mesenteric artery, superior mesenteric artery

3 3. Which of these statements is false?

The right hepatic bud will eventually form the right lobe of the liver.
The cloaca initially forms a common urogenital and gastrointestinal space.
Meckel's diverticulum is a common abnormality caused by failed degeneration of the vitelline duct during development.
The ventral mesentery is completely lost during development.

4 4. Which abnormality involves narrowing of the gastrointestinal tract lumen?

stenosis
atresia
duplication
gastroschisis


References

  1. <pubmed>24549211</pubmed>
  2. <pubmed>22412909</pubmed>