User:Z3417363: Difference between revisions
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Group 2: | |||
Positive Assessment: | |||
So far this page looks great and very organised. I am really impressed by the set out of the information and the way the headings are arranged. It made it really easy for me to navigate around for particular information and not have to look for around aimlessly when I was looking for something in particular. Furthermore I think that the actual categories/sub headings used so far are very concise and effective. For example, I appreciate the brief introduction along with an overview of the molecular mechanisms involved in notch signalling before introducing its roles in embryonic development. This way I was able to have a understanding of what is really involved before understanding how it is important in embryonic development. | |||
The references are also very neatly and correctly done and many times when I did not fully understand a concept I clicked on the citations which took me to the relevant articles and my understanding was clarified. I also really enjoyed the commentary on the specific research papers, for example cardiomyocyte specification and differentiation where you guys actually compared information from separate studies to make the information more whole and relevant. | |||
In the abnormalities section, I think it was really awesome you guys included so many statistics and symptoms and not just a description of the abnormality. | |||
Critical Assessment: | |||
Although everything looks really amazing a couple of improvements that I personally think could be made would make this page really useful to students. | |||
The introduction, although very informative can be simplified a bit more to address criteria 4 and make it a bit easier to understand. This can be done through including an interesting or very simplified diagram to engage the student from the beginning. I would also generally include more diagrams and drawings that are personally drawn as the pictures used although effective, can be difficult to understand when you are learning for the first time. It would also be nice if more words are included in the glossary because there was a quite few words I did not know the meaning of. | |||
Lastly I think it would be a great addition to your page to include another subheading which outlines how the abnormalities are treated as this is something that I was intrigued to discover. | |||
Overall I think your page is going great guys keep it going ! |
Revision as of 01:09, 7 October 2016
Student Information (expand to read) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Individual Assessments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Please leave this template on top of your student page as I will add your assessment items here. Beginning your online work - Working Online in this course
Click here to email Dr Mark Hill | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lab 1 Assessment - Researching a Topic | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
In the lab I showed you how to find the PubMed reference database and search it using a topic word. Lab 1 assessment will be for you to use this to find a research reference on "fertilization" and write a brief summary of the main finding of the paper.
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Lab 2 Assessment - Uploading an Image | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
OK you are now in a group
Initially the topic can be as specific or as broad as you want. Chicken embryo E-cad and P-cad gastrulation[1] References
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Lab 4 Assessment - GIT Quiz | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ANAT2341 Quiz Example | Category:Quiz | ANAT2341 Student 2015 Quiz Questions | Design 4 quiz questions based upon gastrointestinal tract. Add the quiz to your own page under Lab 4 assessment and provide a sub-sub-heading on the topic of the quiz. An example is shown below (open this page in view code or edit mode). Note that it is not just how you ask the question, but also how you explain the correct answer. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lab 5 Assessment - Course Review | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Complete the course review questionnaire and add the fact you have completed to your student page. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lab 6 Assessment - Cleft Lip and Palate | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Lab 7 Assessment - Muscular Dystrophy | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Lab 8 Assessment - Quiz | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A brief quiz was held in the practical class on urogenital development. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lab 9 Assessment - Peer Assessment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Lab 10 Assessment - Stem Cells | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
As part of the assessment for this course, you will give a 15 minutes journal club presentation in Lab 10. For this you will in your current student group discuss a recent (published after 2011) original research article (not a review!) on stem cell biology or technology.
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Lab 11 Assessment - Heart Development | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Read the following recent review article on heart repair and from the reference list identify a cited research article and write a brief summary of the paper's main findings. Then describe how the original research result was used in the review article.
<pubmed>26932668</pubmed>Development | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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lab attendance
Z3417363 (talk) 14:34, 5 August 2016 (AEST)
Z3417363 (talk) 1:13, 2 September 2016 (AEST)
Z3417363 (talk) 1:13, 16 September 2016 (AEST)
Z3417363 (talk) 1:27, 23 September 2016 (AEST)
New sub heading
external link
internal link
https://embryology.med.unsw.edu.au/embryology/index.php/ANAT2341_Lab_1
referencing
PMID 27486480
Lab 1 Assessment
<pubmed>24194470</pubmed>
Summary the cell biology of fertilisation:
Fertilisation is a complex yet essential part of life and the continuation of it. There are significant amounts of research into the components of fertilisation as we try to understand its mechanisms and establish ways of creating successful fertilization. With the introduction of gene manipulation and in vitro technology there has been a great increase in the opportunity to learn more about the molecular mechanisms that regulate the fertilization; an area that is still relatively obscure. This article explores the mechanisms of fertilisation that have been seen to be an essential part of the process, while also shedding lights on events that are not as essential.
Factors regulating fertilization: During this study, gene manipulation and fertilisation of mice was observed and many factors thought to be essential in the classical models seemed not to be as significant whereas some factors revealed themselves to be essential. For example spermatozoa from some of the mice lacked ADAM3 and this suggested that this plays a key role in the fertilisation process of the mice. Factors regulating sperm migration: Calmegin is one of the essential genes required for spermatozoa to migrate into the oviduct. The study conducted an experiment where both wild type and calmegin disrupted spermatozoa was used observe migration habits. It was observed that only the wild sperm migrated to the oviduct while the calmegin disrupted spermatozoa (which are equally motile) remained in the uterus. This result shows the essential mechanism of calmegin in relation to successful fertilisation. Factors regulating the zona-binding ability of spermatozoa: Many studies have postulated that carbohydrates play an imperative role in sperm-zona binding. However through this study many residues which did not contain key carbohydrates still resulted in successful fertilisation indicating that it may not play an important role as hypothesised. This research article aims to present factors that lead to “essential” fertility. It aims to dispel misplaced enthusiasm for research into components of fertilisation that are not as important and may lead to misleading results. It is therefore important to focus gene manipulation and in vitro studies on valid candidate molecules to better understand this complex process of fertilisation
Mark Hill 18 August 2016 - You have added the citation correctly and written an extensive summary of the article. Unfortunately I have had to take marks off the final assessment as you have not followed the assessment criteria "It must be a research article not a Review.", this is a review paper. Reviews are not research articles, though good in providing a timely summary of a topic{s) they do not contain new research data. Please read the assessment criteria carefully.
The cell biology of mammalian fertilisation. Okabe M. Development. 2013 Nov;140(22):4471-9. doi: 10.1242/dev.090613. Review PMID 24194470 |
Assessment 3/5 |
Lab 2
Lab assessment 2
Sperm binding test using unfertilised and fertilised human oocytes[1]
Mark Hill 29 August 2016 - All information Reference, Copyright and Student Image template correctly included with the file and referenced on your page here. | Assessment 5/5 |
Lab attendance 3
Mark Hill 31 August 2016 - Lab 3 Assessment Quiz - Mesoderm and Ectoderm development. | Assessment 2/5 |
Assessment 4
Quiz
Lab 7 Duchenne muscular dystrophy
What is/are the dystrophin mutation(s)?
Dystrophin is encoded by the DMD gene which is a large muscle protein. Recessive mutations in the dystrophin gene on the x chromosome causes Duchenne muscular dystrophy which results in progressive deterioration of muscle tissue and weakness. The dystrophin gene is the largest known human gene and contains 79 exons, DMD occurs when there is a mutation deletion spanning on or multiple exons. These mutations disrupt's the protein's reading frame causing premature stop codons where the transcripts are now susceptible to nonsense decay.
PMC4767260
What is the function of dystrophin?
Dsytrophin is a an X-linked protein assembled by the dystrophin glycoprotein complex. Dystrophin plays an important role in striated muscle cells by linking the extracellular matrix to the actin cytoskeleton and also mediating structural stability of the plasma membrane, ion homoeostasis and transmembrane signalling.
<pubmed>16710609</pubmed>
What other tissues/organs are affected by this disorder?
Dystrophin also plays a significant role in the central and peripheral nervous system and in tissues with a secretory function that from barriers between two functional compartments. These include the blood-brain barrier, choroid plexus and the kidney. There mutations in dystrophin can have large impacts on these tissues/organs aswell.
<pubmed>16710609</pubmed>
What therapies exist for DMD? The only established pharmacological treatment for DMD is corticosteroids to suppress muscle inflammation, however this treatment is limited by its insufficient therapeutic efficacy and considerable side effects.
<pubmed>27621596</pubmed>
What animal models are available for muscular dystrophy?
The mdx mouse, a naturally occurring animal model for DMD, has been available for over a decade , others include hamsters and murines.
<pubmed>11005802</pubmed>
Group 2:
Positive Assessment:
So far this page looks great and very organised. I am really impressed by the set out of the information and the way the headings are arranged. It made it really easy for me to navigate around for particular information and not have to look for around aimlessly when I was looking for something in particular. Furthermore I think that the actual categories/sub headings used so far are very concise and effective. For example, I appreciate the brief introduction along with an overview of the molecular mechanisms involved in notch signalling before introducing its roles in embryonic development. This way I was able to have a understanding of what is really involved before understanding how it is important in embryonic development.
The references are also very neatly and correctly done and many times when I did not fully understand a concept I clicked on the citations which took me to the relevant articles and my understanding was clarified. I also really enjoyed the commentary on the specific research papers, for example cardiomyocyte specification and differentiation where you guys actually compared information from separate studies to make the information more whole and relevant.
In the abnormalities section, I think it was really awesome you guys included so many statistics and symptoms and not just a description of the abnormality.
Critical Assessment:
Although everything looks really amazing a couple of improvements that I personally think could be made would make this page really useful to students.
The introduction, although very informative can be simplified a bit more to address criteria 4 and make it a bit easier to understand. This can be done through including an interesting or very simplified diagram to engage the student from the beginning. I would also generally include more diagrams and drawings that are personally drawn as the pictures used although effective, can be difficult to understand when you are learning for the first time. It would also be nice if more words are included in the glossary because there was a quite few words I did not know the meaning of. Lastly I think it would be a great addition to your page to include another subheading which outlines how the abnormalities are treated as this is something that I was intrigued to discover.
Overall I think your page is going great guys keep it going !
- ↑ <pubmed>17147816</pubmed>