User:Z3415911

Lab Attendance

--Z3415911 (talk) 13:46, 7 August 2015 (AEST)

Test Student 2015

Lab 1 Assessment

PMID:6241855

The aim of this study was to look at in vitro Maturation (IVM) in women with Polycycsitc Ovarian Syndrome (PCOS) undergoing in vitro fertilization (IVF) compared to women who do not have PCOS. To do this the authors of the article wanted too analyse past studies regarding IVM and PCOS so created an algorithm to aid in their search, with the end of the search date being October 15th 2013. Studies deemed eligible for use in this research compared the rates of various outcomes such as live births and cycle cancellations between people with PCOS, PCO and control women undergoing IVM. Animal studies, case reports and trials on ovum recipients were excluded. An excel spreadsheet was created by 3 of the authors to record and sort their data.

The extent of publication bias was not assessed as it was deemed not necessary due to the small study pool per outcome. To evaluate the quality of the data used in this study, the authors used the nine-item Newcastle Ottawa Quality scale. The main outcome measured was live births per women and per cycle. Other measures included clinical pregnancy per woman, miscarriage rate and fertilization rate. Based on the frequencies of the outcomes between the 3 groups, 95% confidence intervals (CI's) were calculated. Two additional analyses were conducted with regards to clinical pregnancy and live births, namely one based on women and the other on cycles. Statistical analysis was done using STATA Software/SE 13.

268 PCOS, 100 PCO and 440 control patients were included in the analysis. The authors found that live birth rates did not differ between PCOS and non-PCOS women was seen in the cycle-based analysis but in the women-based analysis, a slightly higher birth rate was seen for PCOS women. According to both the woman and cycle based approaches, higher rates of clinical pregnancy were seen for PCOS women compared to non-PCOS women. The same trend was seen for implantation rates in women with PCOS compared to women without PCOS. Cancellation rates were lower in women with PCOS in both subgroups however maturation and miscarriage rates did not differ between the 3 groups assessed. Fertilization rates were minimally lower between women with PCOS compared to non-PCOS women.

A higher rate of clinical pregnancy rates were seen in women with PCOS who have undergone stimulation with FSH and hCG priming during both women and cycle based analysis. No pattern between the 3 groups was seen when there was a lack of priming with hCG. When rating the quality of the studies,the scores ranged between 5 and 9, with older studies receiving a lower score compared to newer studies. To conclude, it was found that IVM appears to be a good approach when it comes to treating women with PCOS during IVF as opposed to women without PCOS. It is an efficient treatment option in terms of implantation, clinical pregnancy and cycle cancellation rates.

References

PMID 26244658

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