User:Z3345331
Lab Attendance
--Mark Hill (talk) 10:47, 6 August 2015 (AEST) Thanks for setting up your page. We will be talking more about this in the Practical on Friday.
--Z3345331 (talk) 13:46, 7 August 2015 (AEST)
--Z3345331 (talk) 14:05, 14 August 2015 (AEST)
Online Assessment
Lab 1 Assessment
Article 1
<pubmed>26208448</pubmed> Summary
The study aimed to investigate the relationship between ethnicity and IVF outcome which is still inconclusive. It investigated a large population (13,473) over the period from 2008 to 2012. The result of the study was then compared with the results of meta-analysed data from 16 published studies.
Method
The participants included all women undergoing their first non-donor cycle of IVF or intracytoplasmic sperm injection (ICSI) at any Centres for Assisted Reproduction (CARE) clinic in the UK and Ireland between 2008 and 2012. Each participant was required to complete her demographic profile. A total of 17 individual ethnic groups were divided into seven main categories: White (White British, White Irish, any other White), South Asian (Indian, Pakistani, Bangladeshi, any other Asian background), Black (Black Caribbean, Black African, other Black), Chinese, mixed (White and Black Caribbean, White and Black African, White and Asian, any other mixed), any other and not stated. Univariate and multiple logistic regression analyses were used to estimate the contribution of ethnicity to live birth rate. The data was then adjusted for age, body-mass index, cause of infertility, duration of infertility, previous live birth, previous spontaneous abortion and number of embryos transferred.
Results
Both of the cohort study and the meta-analysed results showed that Black and South Asian women have lower live birth rates after IVF treatment compared to White women. Further research needs to be conducted to explain the difference of live birth rates between different ethnic groups and thus improve IVF outcome for all women.
Article 2
<pubmed>26131230</pubmed> Summary
The study aimed to investigate whether HCV infection is related to IVF outcomes. It analysed a relatively large population (1,424) compared to previous studies. The samples were grouped according to their sexes and the effect of HCV infection on IVF outcomes was evaluated.
Method
The samples including in this study were couples opting for IVF between 2008 and 2013 and were separated into three groups: Group A - 90 couples where the female was HCV positive; Group B - 78 couples where the male was HCV positive and Group C - 1256 control couples where both the male and female were HCV negative by seroanalysis and the presence of HCV RNA. The sperm concentration, progressive motility (PR) percentage, sperm volume, Normal Sperm Morphology (NSM) percentage and TZI (teratozoospermia index) were checked after the semen samples were obtained. HCV-Ab were detected by ELISA. After the IVF procedures, some calculation and statistical analysis were performed.
Results
The result showed that no differences were observed in IVF indications and ovarian stimulation when comparing the three groups. Moreover, semen parameters from male participants including concentration; PR differences; volume; NSM percentage and TZI were similar in both the group with seropositive men and the control group. The effect of HCV infection on pregnancy outcomes were finally investigated and no differences on pregnancy rates per cycle were found.
Lab 2 Assessment
Hatched Blastocyst [1] PMID 24970979
Test Page 2015
References
PMID 26244658
look at this.[2]
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