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--[[User:Z3332327|Z3332327]] 12:55, 28 July 2011 (EST)
--[[User:Z3332327|Z3332327]] 12:55, 28 July 2011 (EST)


[[User:Z3332327|Lisa Xiao]] 22:25, 3 August 2011 (EST)
[[User:Z3332327|Z3332327]] 22:25, 3 August 2011 (EST)




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1.Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilization.
'''1.Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilization.'''


ZP3 is the only glycoprotein that functions as a sperm receptor. It is known that ZP3 protein, in the zona pellucida, binds sperm and stimulates acrosomal exocytosis, enabling the process of zonal penetration (Clark, GF). In order to prevent polyspermy, it is believed that certain enzymes break down the zona pellucida and hence inactivating the ZP3 glycoprotein.
ZP3 is the only glycoprotein that functions as a sperm receptor. It is known that ZP3 protein, in the zona pellucida, binds sperm and stimulates acrosomal exocytosis, enabling the process of zonal penetration (Clark, GF). In order to prevent polyspermy, it is believed that certain enzymes break down the zona pellucida and hence inactivating the ZP3 glycoprotein.


Clark, G.F. (2011).The molecular basis of mouse sperm-zona pellucida binding: a still unresolved issue in developmental biology. ''Reproduction''.
Clark, G.F. (2011).The molecular basis of mouse sperm-zona pellucida binding: a still unresolved issue in developmental biology. ''Reproduction''.
[[User:Z3332327|Lisa Xiao]]

Revision as of 17:41, 8 August 2011


Lab 4 Online Assessment

  1. The allantois, identified in the placental cord, is continuous with what anatomical structure?
  2. Identify the 3 vascular shunts, and their location, in the embryonic circulation.
  3. Identify the Group project sub-section that you will be researching. (Add to project page and your individual assessment page)



--Z3332327 12:55, 28 July 2011 (EST)

Z3332327 22:25, 3 August 2011 (EST)


Lab 1 Online Assessment

1. Identify the origin of In Vitro Fertilization and the 2010 nobel prize winner associated with this technique.

An American doctor, John Rock was the first to extract an intact fertilised egg, which is an important technique used to complete IVF today. Robert Edwards was awarded the 2010 nobel prize for his success in replicating conception through IVF.

2. Identify a recent paper on fertilisation and describe its key findings.

Pregnancy after Age 50: Defining Risks for Mother and Child. Kort DH, Gosselin J, Choi JM, Thornton MH, Cleary-Goldman J, Sauer MV. Am J Perinatol. 2011 Aug 1.

In 2011, a study was performed on women over the age of 50 undergoing IVF treatment and its associated risks. The study shows that with increased maternal age, the risks associated with birth defects and maternal complications is greatly increased.

3. Identify 2 congenital anomalies.

Cleft Palate and congenital hip dysplasia

Lisa Xiao 12:51, 4 August 2011 (EST)


Lab 2 Online Assessment

1.Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilization.

ZP3 is the only glycoprotein that functions as a sperm receptor. It is known that ZP3 protein, in the zona pellucida, binds sperm and stimulates acrosomal exocytosis, enabling the process of zonal penetration (Clark, GF). In order to prevent polyspermy, it is believed that certain enzymes break down the zona pellucida and hence inactivating the ZP3 glycoprotein.

Clark, G.F. (2011).The molecular basis of mouse sperm-zona pellucida binding: a still unresolved issue in developmental biology. Reproduction.

Lisa Xiao