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Lab Attendace

Lab 1 Attendance:

--z3293267 12:55, 28 July 2011 (EST)

Lab 2 Attendance:

--z3293267 13:03, 4 August 2011 (EST)

Lab 3 Attendance:

--z3293267 12:43, 11 August 2011 (EST)

Lab 1: Assessment

Identify the origin of In Vitro Fertilization and the 2010 Nobel Prize winner associated with this technique.

John Rock, an American obstetrician and gynecologist, was a pioneer in in vitro fertilization and sperm freezing. He helped many of his patients achieve pregnancy and became known as a "ground-breaking infertility specialist." In 1977, Patrick Steptoe and Robert Edwards successfully carried out a pioneering conception which resulted in the birth of the world's first baby to be conceived by IVF.
Robert G. Edwards was awarded the 2010 Nobel Prize in Physiology or Medicine.

Identify a recent paper on fertilisation and describe its key findings.

The article, Correlation of Body Mass Index with Outcome of In Vitro Fertilization in a Developing Country, examined individuals in a developing country, examining the relationship between their body mass index and the outcome of in vitro fertilization. It correlated ovarian response to stimulation and IVF outcome according to the women's BMI. The conclusion came to an increased BMI is associated with poorer IVF outcome. [1]

Identify 2 congenital anomalies.

  • Down syndrome (Trisomy 21)
  • Turner's syndrome

--Mark Hill 10:03, 3 August 2011 (EST) These answers are fine.

Lab 2: Assessment

Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilization.

The ZP protein that binds to the spermatozoa is the ZP3. Plasma membranes of the spermatozoa and oocyte fuse, during fertilisation, and the head and tail of the spermatozoa enter the oocyte, leaving the spermatozoa's plasma membrane attached to the oocyte's plasma membrane.

Identify a review and a research article related to your group topic.

Turner Syndrome can be defined as loss or abnormality of the second X chromosome in at least one cell line in a phenotypic female.[2]
The article, Optimising management in Turner syndrome: from infancy to adult transfer, reviewed that there is a potential for increased height with growth hormone treatment. Also discussed is the spectrum of gonadal function, ranging from the onset of spontaneous puberty and the potential for fertility to complete gonadal failure.[3]

Lab 3: Assessment

What is the maternal dietary requirement for late neural development?

A maternal dietary requirement for late neural development is choline. Choline is particularly used to support the fetus' developing nervous system.

Upload a picture relating to your group project.

Chromosome segregation defects associated with abnormal spindles in UBE3A shRNA knockdown clones.[4]

Chromosome segregation defects associated with abnormal spindles in UBE3A shRNA knockdown clones.jpg

Chromosome segregation defects associated with abnormal spindles in UBE3A shRNA knockdown clones.


  1. <pubmed>21792549</pubmed>
  2. <pubmed>2029883</pubmed>
  3. <pubmed>2082783</pubmed>
  4. <pubmed>21633703</pubmed>