User:Z3291317

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Lab 4 Online Assessment

1. The allantois, identified in the placental cord, is continuous with what anatomical structure?
2. Identify the 3 vascular shunts, and their location, in the embryonic circulation.
3. Identify the Group project sub-section that you will be researching. (Add to project page and your individual assessment page)

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--Z3291317 12:55, 28 July 2011 (EST)

--Mark Hill 09:58, 3 August 2011 (EST) Where are your Lab 1 assessment answers? Need to added before Lab 2.

Lab 1 Assessment

1. Identify the origin of In Vitro Fertilization and the 2010 nobel prize winner associated with this technique.

In 1973, the first pregnancy conducted by IVF on a human oocyte was done at Monash University, but it had only lasted a few days and thus a baby wasn't delivered. However, it was in 1977 in which Steptoe and Edwards were able to carry out a IVF process which would bring about the world first IVF baby to be born, Louise Brown from the UK.

It was due to this success that RG Edwards had been awarded a 2010 Nobel Prize in the field of Physiology or Medicine. It was awarded for his role “for the development of in vitro fertilisation”

2. Identify a recent paper on fertilisation and describe its key findings.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011 Apr;28(2):156-9.

Effects of abnormal structure of sperm chromatin on the outcome of in vitro fertilization and embryo transfer

[Article in Chinese] GU LJ, CHEN ZW, LU WH, XU JF, LI M, CHEN ZJ.

Center for Reproductive Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030 P. R. China.

This study was designed to see the effects of an abnormality in sperm chromatin structure in the degree of success when In-Vitro fertilization and Embryo Transfer is conducted. The study showed that DNA fragmentation and Chromatin packaging defect in the sperm does not have a correlation with fertilization rate. However, it did show that these two problems in sperm are more prevalent in pregnancies that have failed compared to those which have achieved clinical pregnancy.

3. Identify 2 congenital anomalies.

• Dandy-Walker Syndrome
• Anencephaly

--Z3291317 18:55, 3 August 2011 (EST)

--Z3291317 11:50, 4 August 2011 (EST)

Lab 2 Assessment

1. Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilisation.

Enzyme ZP3 which found in the Zona Pellucida acts as a the primary receptor to which spermatozoa bind to during fertilisation . When the spermatozoa fuses into the oocyte (causing fertilisation), there is a cortical reaction which alters the ZP3 in the Zona Pellucida. During this cortical reaction, the released cortical granules from the spermatozoa remove ZP3’s carbohydrate which results in ZP3’s structure to change, thus preventing polyspermy from occurring.

2.Identify a review and a research article related to your group topic.

Disease proposed for the zgroup project:Tetralogy of Fallot

Review Article:

Orphanet J Rare Dis. 2009 Jan 13;4:2.

Tetralogy of Fallot.

Bailliard F, Anderson RH.

North Carolina Children's Heart Center, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. frederique_bailliard@med.unc.edu

Link:

Research Article:

J Med Genet. 2010 May;47(5):321-31. Epub 2009 Nov 30.

Comprehensive genotype-phenotype analysis in 230 patients with tetralogy of Fallot.

Rauch R, Hofbeck M, Zweier C, Koch A, Zink S, Trautmann U, Hoyer J, Kaulitz R, Singer H, Rauch A.

Institute of Medical Genetics, Schorenstrasse 16, CH-8603 Zurich-Schwerzenbach, Switzerland. anita.rauch@medgen.uzh.ch

Link:

--Z3291317 16:45, 7 August 2011 (EST)