From Embryology

Lab Attendance

Lab 1: Z3289738 11:49, 25 July 2012 (EST)

Individual Assessments

Lab 1

  1. Identify the origin of In Vitro Fertilization and the 2010 nobel prize winner associated with this technique and add a correctly formatted link to the Nobel page.
  1. Identify and add a PubMed reference link to a recent paper on fertilisation and describe its key findings (1-2 paragraphs).

Ye Chun Ruan, Jing Hui Guo, Xinmei Liu, Runju Zhang, Lai Ling Tsang, Jian Da Dong, Hui Chen, Mei Kuen Yu, Xiaohua Jiang, Xiao Hu Zhang, Kin Lam Fok, Yiu Wa Chung, Hefeng Huang, Wen Liang Zhou, Hsiao Chang Chan Activation of the epithelial Na(+) channel triggers prostaglandin E(2) release and production required for embryo implantation. Nat Med: 2012; PMID:22729284

This article looks into the process of embryo implantation. It demonstrates how the activation of the epithelial Na(+) channel triggers prostoglandin E(2) release,phosphorylation of teh transcription factor CREB and upregulation of cyclooxygenase 2, the enzyme required for prostaglandin production and implantation. They detected maximum Epithelial Na(+) channel activation at the time of implantation in mice, and that blocking or knocking down this channel in mice resulted in failure to implant. These results indicate the importance of the Epithelial Na(+) Channel in the process of implantation, and the consequences of defects such as miscarriage and low success rates in IVF.