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'''Are satellite cells (a) necessary for muscle hypertrophy and (b) generally involved in hypertrophy?'''
 
'''Are satellite cells (a) necessary for muscle hypertrophy and (b) generally involved in hypertrophy?'''
  
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'''Why does chronic low frequency stimulation cause a fast to slow fibre type shift? '''
 
'''Why does chronic low frequency stimulation cause a fast to slow fibre type shift? '''

Revision as of 13:37, 15 September 2011


Lab 4 Online Assessment

  1. The allantois, identified in the placental cord, is continuous with what anatomical structure?
  2. Identify the 3 vascular shunts, and their location, in the embryonic circulation.
  3. Identify the Group project sub-section that you will be researching. (Add to project page and your individual assessment page)



Lab Attendance

--Z3288729 12:16, 28 July 2011 (EST)

--z3288729 11:12, 4 August 2011 (EST)

--Sarah Jenkins 11:10, 18 August 2011 (EST)

--Sarah Jenkins 11:11, 25 August 2011 (EST)

--Sarah Jenkins 12:28, 1 September 2011 (EST)

--Sarah Jenkins 11:31, 15 September 2011 (EST)

Lab One

Identify the origin of In Vitro Fertilization and the 2010 nobel prize winner associated with this technique.

In vitro fertilisation began in 1978 when Edwards RG successfully carried out the process. He won the nobel prize for his work in 2010.

Identify a recent paper on fertilisation and describe its key findings.

Actin, more than just a housekeeping protein at the scene of fertilization.

This research project looked into the role of actin in fertilisation. It was found that it is an important molecule, significant in modulation of fertilisation. The rearrangement of the actin cytoskeleton of a fertilised egg plays a role in allowing only one sperm to enter the cell. [1]


Identify 2 congenital anomalies.

Ectrodactyly- a lack of one or more digits of the hand or foot

Spina Bifida- incomplete closing of the embryonic neural tube

Lab Two

Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilization.

zona pellucida glycoprotein 3 (ZP3) acts as a sperm receptor. [2]. ZP3 surrounds the oocyte, and the sperm binds to it as a way to enter the cell. Once a sperm has entered the oocyte, mechanisms to prevent polyspermy are put in place. The IP3 pathway is activated and in increase in intraceellular calcium results in alteration of ZP3 to prevent any more sperm entering the oocyte.


Identify a review and a research article related to your group topic. (Paste on both group discussion page with signature and on your own page)


Review Mammalian models of Duchenne Muscular Dystrophy: pathological characteristics and therapeutic applications.

Primary Detection of duchenne/becker muscular dystrophy carriers in a group of Iranian families by linkage analysis.

Lab Three

What is the maternal dietary requirement for late neural development?

Folate is an important dietary requirement to prevent neural tube defects [[1]]. Another is iodine, in order to prevent neurological cretinism following maternal hypothyroidism [[2]].

Upload a picture relating to you group project.

DiGeorge T cell receptor Diversity post thymus transplant.jpg


--Mark Hill 12:20, 16 August 2011 (EST) Good image and the information included is correct. I don't really like the image name as it does not indicate what the image is about. Looking at the original figure legend is also not as helpful, perhaps modified from the paper title "T-cell receptor diversity with thymus transplantation for DiGeorge anomaly" or along those lines.


Lab Four

The allantois, identified in the placental cord, is continuous with what anatomical structure?

The allantois is a membranous sac that is continuous with the splanchnic mesoderm and the embryonic gastrointestinal tract.

Identify the 3 vascular shunts, and their location, in the embryonic circulation

  • Ductus arteriosus- It attaches the pumonary artery to the aortic arch so that blood bypasses the lungs.
  • Ductus venosus - shunts half of the arterial blood flow from the umbilical cord so that it is able to bypass the liver
  • Foramen ovale- shunts oxygenated blood from the right atrium to left atrium so bypass the ventricles.

Identify the group project subsection you will be researching

  • Introduction
  • Historical background
  • Diagnosis

Lab Five

Which side (L/R) is most common for diaphragmatic hernia and why?

Diaphragmatic heriation occurs most commonly on the left side [3]. Herniation occurs when there is abnormal closure of the pleuroperitoneal folds. These folds close to separate the lungs from the gut. The right side often closes first, and as such leaves it more likely for gastrointestinal structures to move up before the membrane is fused closed.

Lab Six

What week of development do the palatal shelves fuse?

Week 9

What animal model helped elucidate the neural crest origin and migration of cells?

Chick-Quail Chimeras

What abnormality results from neural crest not migrating into the cardiac outflow tract?

Tetralogy of Fallot


Lab Seven

Are satellite cells (a) necessary for muscle hypertrophy and (b) generally involved in hypertrophy?

a) yes

b) no

Why does chronic low frequency stimulation cause a fast to slow fibre type shift?

group project

  • Angelo DiGeorge. In the mid 1960's, Angelo DiGeorge noticed a similar combination of clinical features in some children. He named the syndrom after himself. The symptoms that he recognised were hypoparathyroidism, underdeveloped thymus, conotruncal heart defects and a cleft lip/palate. [4]
  • Robert Shprintzen described patients with similar symptoms (cleft lip, heart defects, absent or underdeveloped thymus, hypocalcemia) and named the group of symptoms as velo-cardio-facial syndrome. [5]
  • Lischner and Huff determined that there was a deficiency in T cells was present in 10-20% of the normal thymic tissue of DiGeorge syndrome patients (1975). [6]
  • ‘’’Cleveland’’’ determined that a thymus transplant in patients of DiGeorge was able to restore immunlogical function (1975). [7]
  • Finley and others identified that the cardiac failure of infants suffering from DiGeorge could be related to abnormal development of structures derived from the pouches of the 3rd and 4th pouches in the pharangeal arches. [8]
  • 1980s technology develops to identify that these patients have part of a chromosome missing. [9]
  • '’’De La Chapelle’’’ suspects that a chromosome deletion in 22q11 is responsible for diGeorge syndrome (1981) [10]
  • ’’'Ammann'’’ suspects that DiGeorge symdrome may be caused by alcoholism in the mother during pregnancy. There appears to be abnormalities between the two conditions such as facial features, cardiovascular, immune and neural symptoms (1982). [11]

Reference List