Unequal Cleavage Movie 1: Difference between revisions

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Human Direct Unequal Cleavage

<html5media height="510" width="510">File:Unequal_cleavage_1.mp4</html5media>

This movie shows the initial unequal cleavage of the zygote to blastomeres.

The original study population showed the total incidence of direct unequal cleavage (DUC) per embryo occupying the first three cleavages were 26.1%.

Depending of the cell stage, DUC rate was 9.8% at first cleavage (DUC-1), 9.1% at second cleavage (DUC-2), and 3.7% at third cleavage (DUC-3) with 3.6% of embryos exhibiting multiple DUCs (DUC-Plus).

Links: MP4 | Week 1 | zygote | mitosis | Movies

Reference

Zhan Q, Ye Z, Clarke R, Rosenwaks Z & Zaninovic N. (2016). Direct Unequal Cleavages: Embryo Developmental Competence, Genetic Constitution and Clinical Outcome. PLoS ONE , 11, e0166398. PMID: 27907016 DOI.

Zhan Q, Ye Z, Clarke R, Rosenwaks Z, Zaninovic N (2016) Direct Unequal Cleavages: Embryo Developmental Competence, Genetic Constitution and Clinical Outcome. PLoS ONE 11(12): e0166398. https://doi.org/10.1371/journal.pone.0166398

Copyright

© 2016 Zhan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cite this page: Hill, M.A. (2024, April 23) Embryology Unequal Cleavage Movie 1. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Unequal_Cleavage_Movie_1

What Links Here?

@@ Line 1: / Line 1: @@
-[[Media:Unequal_cleavage_1.mp4|Play]]
+{{Movie header}}
+==Human Direct Unequal Cleavage==
+{|
+|-
+| width=520px|<html5media height="510" width="510">File:Unequal_cleavage_1.mp4</html5media>
-PLoS One. 2016 Dec 1;11(12):e0166398. doi: 10.1371/journal.pone.0166398. eCollection 2016.
+|
-Direct Unequal Cleavages: Embryo Developmental Competence, Genetic Constitution and Clinical Outcome.
+This movie shows the initial unequal cleavage of the zygote to blastomeres.
-Zhan Q1, Ye Z1, Clarke R1, Rosenwaks Z1, Zaninovic N1.
-Author information
-Abstract
+The original study population showed the total incidence of direct unequal cleavage (DUC) per embryo occupying the first three cleavages were 26.1%.
-OBJECTIVE:
-To investigate the prevalence, developmental potential, chromosomal constitution and clinical outcome of embryos with direct unequal cleavages (DUC).
+Depending of the cell stage, DUC rate was 9.8% at first cleavage (DUC-1), 9.1% at second cleavage (DUC-2), and 3.7% at third cleavage (DUC-3) with 3.6% of embryos exhibiting multiple DUCs (DUC-Plus).
-DESIGN:
-A retrospective observational study.
-SETTING:
-Academic Institution.
-PARTICIPANT:
+:'''Links:''' [[Media:Unequal_cleavage_1.mp4|MP4]] | [[Week 1]] | {{zygote}} | {{Mitosis}} | [[Movies]]
-,261 embryos from 3,155 cycles cultured in EmbryoScope®.
-RESULTS:
+|}
-The total incidence of DUCs per embryo occupying the first three cleavages were 26.1%. Depending of the cell stage, DUC rate was 9.8% at first cleavage (DUC-1), 9.1% at second cleavage (DUC-2), and 3.7% at third cleavage (DUC-3) with 3.6% of embryos exhibiting multiple DUCs (DUC-Plus). The occurrence of DUCs was not correlated with female gamete age or source. The incidence of DUC-1 was significantly higher in embryos fertilized by epididymal and testicular sperm (13.6% and 11.4%, respectively) compared to ejaculated sperm (9.1%, all p<0.05). The total incidences of DUCs were strongly correlated with the onset of blastomere multinucleation (MNB) during the first three divisions. In MNB embryos, DUCs incidence are two to three times more likely to develop when compared to non-MNB embryos (OR = 3.11, 95% CI [2.64, 3.67] at 1-cell stage, OR = 2.64, 95% CI [2.39, 2.91] at 2-cell stage and OR = 2.51, 95% CI [1.84, 3.43] at 4-cell stage). The blastocyst formation rates gradually decreased from 61.0% in non-DUC to 40.2% in DUC-3, 18.8% in DUC-2, 8.2% in DUC-1 and 5.6% in multiple DUC embryos (DUC-Plus). The known implantation rates (FH) for day 3 (D3) transfers were 12.42% (n = 3172) in Non-DUC embryos, 6.3% (n = 127) in DUC-3, and 2.7% (n = 260) in DUC-2 embryos. No live births resulted from either DUC-1 (n = 225) or DUC-Plus (n = 100) embryo transfers. For blastocyst transfers, lower implantation rates (33.3%) but similar live birth (LB) rates (40%) were observed if DUC blastocysts were transferred. Comparatively rates in Non-DUC blastocyst were 45.2% and 34.8%, respectively. The euploid rate gradually increased from DUC-1, -2, -3 to Non-DUC (13.3%, 19.5%, 33.3%, 45.6%, p<0.001) for D3 biopsied embryos. Interestingly, the trend of decreased euploidy disappeared in DUC D5/6 biopsied embryos and similar rates were exemplified in DUC (D5 56.3%, D6 35.6%) vs. non-DUC (D5 51.4%, D6 33.8%) embryos.
+===Reference===
-CONCLUSION:
+{{#pmid:27907016}}
-Blastocyst formation, implantation potential and euploid rate were significantly reduced in DUC embryos. DUC embryos should be deselected for D3 transfers, but should be culture to blastocyst stage for possible ET.
-PMID: 27907016 PMCID: PMC5132229 DOI: 10.1371/journal.pone.0166398
+Zhan Q, Ye Z, Clarke R, Rosenwaks Z, Zaninovic N (2016) Direct Unequal Cleavages: Embryo Developmental Competence, Genetic Constitution and Clinical Outcome. PLoS ONE 11(12): e0166398. https://doi.org/10.1371/journal.pone.0166398
+====Copyright====
+© 2016 Zhan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
+{{Footer}}