Template talk:Spleen Timeline Table: Difference between revisions
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{| class="prettytable" | {| class="prettytable" | ||
|+ '''Human Spleen Development''' | |+ '''Human Spleen Development''' | ||
|-bgcolor="CEDFF2" | |-bgcolor="CEDFF2" | ||
! width=120px|<center>Week</center> | ! width=120px|<center>Embryonic Week</center> | ||
! width=180px|<center>Carnegie Stage</center> | ! width=180px|<center>Carnegie Stage</center> | ||
! Feature | ! Feature | ||
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| Arteries and veins parallel entries at this stage. | | Arteries and veins parallel entries at this stage. | ||
|-bgcolor="CEDFF2" | |-bgcolor="CEDFF2" | ||
! width=120px|<center>Week {{FA}}</center> | ! width=120px|<center>Fetal Week {{FA}}</center> | ||
! width=180px|<center>Gestational Age {{GA}}</center> | ! width=180px|<center>Gestational Age {{GA}}</center> | ||
! Feature | ! Feature | ||
| Line 94: | Line 93: | ||
| <center>Week 15</center> | | <center>Week 15</center> | ||
| <center>Week 17</center> | | <center>Week 17</center> | ||
| alpha-smooth muscle actin | | reticulum cells (alpha-smooth muscle actin-positive) scattered around the arterioles | ||
|- | |-bgcolor="F5FAFF" | ||
| <center>Week 18-21</center> | | <center>Week 18-21</center> | ||
| <center>Week 20-23</center> | | <center>Week 20-23</center> | ||
| | | reticulum cells increase in number and began to form a reticular framework.<br>Accumulation of T and B lymphocytes within this framework, and a primitive white pulp was observed around the arterioles. | ||
|- | |- | ||
| <center>Week 22</center> | | <center>Week 22</center> | ||
| <center>Week 24</center> | | <center>Week 24</center> | ||
| antigenic diversity | | reticular framework antigenic diversity, and T and B lymphocytes were segregated in the framework.<br>T lymphocytes were sorted into the alpha-SMA-positive reticular framework, and the periarteriolar lymphoid sheath (PALS) was formed around the arteriole.<br>B lymphocytes aggregated in eccentric portions to the PALS and formed the lymph follicle (LF, reticular framework alpha-SMA-negative). | ||
|- | |-bgcolor="F5FAFF" | ||
| <center>Week 24</center> | | <center>Week 24</center> | ||
| <center>Week 26</center> | | <center>Week 26</center> | ||
| marginal zone appears in reticular framework around the white pulp. | | marginal zone appears in reticular framework around the white pulp.<br> | ||
|- | |- | ||
| colspan=3|Human embryonic data{{#pmid:25403423|PMID25403423}} and fetal data {{#pmid:19255788|PMID19255788}} Links: {{spleen}} | [[Kyoto Collection]] | [[Timeline human development]] | | colspan=3|Human embryonic data{{#pmid:25403423|PMID25403423}} and fetal data {{#pmid:19255788|PMID19255788}} Links: {{spleen}} | [[Kyoto Collection]] | [[Timeline human development]] | ||
|}<noinclude>[[Category:Spleen]][[Category:Human]][[Category:Timeline]][[Category:Template]][[Category:Table]]</noinclude> | |}<noinclude>[[Category:Spleen]][[Category:Human]][[Category:Timeline]][[Category:Template]][[Category:Table]][[Category:Fetal]]</noinclude> | ||
Latest revision as of 10:28, 12 February 2019
Embryonic
| Feature | ||
|---|---|---|
| Carnegie stage 14 to 17
appears as a bulge in the dorsal mesogastrium. Mesothelium pseudostratified. | ||
| Mesothelium (pseudostratified} replaced with high columnar cells and then low columnar cells. | ||
| Basement membrane present after this stage. | ||
| Hematopoietic cells detected. | ||
| Spleen is now apparent. Mesenchymal cells differentiated from cells in dorsal mesogastrium. Sinus and hilus formation after this stage. | ||
| Arteries and veins parallel entries at this stage. | ||
| Human data.[1] Links: spleen | Kyoto Collection | Timeline human development | ||
Fetal
Fetal data from study from week 15 (GA 17) to week 38 (GA 40).[2]
- week 15 (17 GA) - alpha-smooth muscle actin (alpha-SMA)-positive reticulum cells scattered around the arterioles.
- week 18 to 21 (20 - 23 GA) - alpha-SMA-positive reticulum cells increase in number and began to form a reticular framework. An accumulation of T and B lymphocytes occurred within the framework, and a primitive white pulp was observed around the arterioles.
- week 22 (24 GA) - antigenic diversity of the reticular framework was observed, and T and B lymphocytes were segregated in the framework. T lymphocytes were sorted into the alpha-SMA-positive reticular framework, and the periarteriolar lymphoid sheath (PALS) was formed around the arteriole. B lymphocytes aggregated in eccentric portions to the PALS and formed the lymph follicle (LF). The reticular framework of the LF was alpha-SMA-negative.
- week 24 (26 GA) - marginal zone appeared in the alpha-SMA-positive reticular framework around the white pulp.
Combined
| Feature | ||
|---|---|---|
| Carnegie stage 14 to 17
appears as a bulge in the dorsal mesogastrium. Mesothelium pseudostratified. | ||
| Mesothelium (pseudostratified} replaced with high columnar cells and then low columnar cells. | ||
| Basement membrane present after this stage. | ||
| Hematopoietic cells detected. | ||
| Spleen is now apparent. Mesenchymal cells differentiated from cells in dorsal mesogastrium. Sinus and hilus formation after this stage. | ||
| Arteries and veins parallel entries at this stage. | ||
| Feature | ||
| reticulum cells (alpha-smooth muscle actin-positive) scattered around the arterioles | ||
| reticulum cells increase in number and began to form a reticular framework. Accumulation of T and B lymphocytes within this framework, and a primitive white pulp was observed around the arterioles. | ||
| reticular framework antigenic diversity, and T and B lymphocytes were segregated in the framework. T lymphocytes were sorted into the alpha-SMA-positive reticular framework, and the periarteriolar lymphoid sheath (PALS) was formed around the arteriole. B lymphocytes aggregated in eccentric portions to the PALS and formed the lymph follicle (LF, reticular framework alpha-SMA-negative). | ||
| marginal zone appears in reticular framework around the white pulp. | ||
| Human embryonic data[1] and fetal data [2] Links: spleen | Kyoto Collection | Timeline human development | ||
- ↑ 1.0 1.1 Endo A, Ueno S, Yamada S, Uwabe C & Takakuwa T. (2015). Morphogenesis of the spleen during the human embryonic period. Anat Rec (Hoboken) , 298, 820-6. PMID: 25403423 DOI.
- ↑ 2.0 2.1 Satoh T, Sakurai E, Tada H & Masuda T. (2009). Ontogeny of reticular framework of white pulp and marginal zone in human spleen: immunohistochemical studies of fetal spleens from the 17th to 40th week of gestation. Cell Tissue Res. , 336, 287-97. PMID: 19255788 DOI.
