Template:X Inactivation Vignette 2

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Historic Embryology
Murray Barr

[Murray L. Barr (1908-1995) was a Canadian researcher who, along with E. Bertram, first identified the inactivated x chromosome (Barr body) as an extension from the nucleus in female cells.

"An interesting and useful variant is the study of blood films. In females only, there is an appendage with special characteristics and probably containing the sex chromatin, attached to a lobe of the nucleus in a small proportion of neutrophilic leukocytes."[1]

  1. BARR ML. (1956). The sex chromatin and its bearing on errors of sex development. Can Med Assoc J , 74, 419-22. PMID: 13304780