Template:Week 4 Embryo Stages and Events table: Difference between revisions

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{| class="wikitable mw-collapsible mw-collapsed"
{| class="wikitable mw-collapsible mw-collapsed"
! colspan=3|Week 4 - Embryo Stages and Events ({{GA}} week 6) 
! colspan=3|[[Week 4]] - Human Embryo Stages and Events ({{GA}} week 6) 
|-
| colspan=3|{{Week}}
|-
|-bgcolor="FAF5FF"
|-bgcolor="FAF5FF"
| <center>'''Day'''</center>
| <center>'''Day'''</center>
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| [[File:Stage10_dorsal1.jpg|200px]] [[File:Stage10-dorsal2.jpg|200px]]  
| [[File:Stage10_dorsal1.jpg|200px]] [[File:Stage10-dorsal2.jpg|200px]]  


[[Neural_Crest_Development|Neural Crest]] - differentiation at spinal cord level from day 22 until day 26  
{{Neural crest}} - differentiation at spinal cord level from day 22 until day 26  


[[Neural_System_Development|Neural]] - neural folds begin to fuse near the junction between brain and spinal cord, when [[Neural_Crest_Development|Neural Crest]] - cells are arising mainly from the neural ectoderm  
{{Neural}} - neural folds begin to fuse near the junction between brain and spinal cord, when {{Neural crest}} - cells are arising mainly from the neural ectoderm  


[[Neural_Crest_Development|Neural Crest]] - trigeminal, facial, and postotic ganglia components visible<ref><pubmed>17848161</pubmed></ref>
{{Neural crest}} - trigeminal, facial, and postotic ganglia components visible{{#pmid:17848161|PMID17848161}}


[[Neural_Crest_Development|Neural Crest]] - migration of vagal level neural crest cells begins (7-10 somite stage)  
{{Neural crest}} - migration of vagal level neural crest cells begins (7-10 somite stage)  


[[Neural_System_Development|Neural]] - Brain rostral neural tube forms 3 primary brain vesicles (week 4)  
{{Neural}} - Brain rostral neural tube forms 3 primary brain vesicles (week 4)  


[[Respiratory_System_Development|Respire]] - Week 4 laryngotracheal groove forms on floor foregut.
{{Respiratory}} - Week 4 laryngotracheal groove forms on floor foregut.


|-
|-
| <center>23</center>
| <center>23</center>
| &nbsp;
| &nbsp;
| [[Cardiovascular_System_Development|Heart]] - begins to beat in Humans by day 22-23, first functioning embryonic organ formed.
| {{Heart}} - begins to beat in Humans by day 22-23, first functioning embryonic organ formed.


|-
|-
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| [[File:Stage11_bf1c.jpg|200px|link=Carnegie stage 11]]
| [[File:Stage11_bf1c.jpg|200px|link=Carnegie stage 11]]


[[Endocrine_-_Thyroid_Development|Thyroid]] - thyroid median endodermal thickening in the floor of pharynx  
{{Thyroid}} - thyroid median endodermal thickening in the floor of pharynx  


[[Neural_System_Development|Neural]] - rostral (or cephalic) neuropore closes within a few hours; closure is bidirectional, it takes place from the dorsal and terminal lips and may occur in two areas simultaneously. The two lips, however, behave differently.  
{{Neural}} - rostral (or cephalic) neuropore closes within a few hours; closure is bidirectional, it takes place from the dorsal and terminal lips and may occur in two areas simultaneously. The two lips, however, behave differently.  


Optic ventricle appears
Optic ventricle appears
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| [[File:Stage12_bf1c.jpg|200px|link=Carnegie stage 12]]
| [[File:Stage12_bf1c.jpg|200px|link=Carnegie stage 12]]


[[Endocrine_-_Pituitary_Development|Pituitary]] - Week 4  hypophysial pouch, Rathke's pouch, diverticulum from roof  
{{Pituitary}} - Week 4  hypophysial pouch, Rathke's pouch, diverticulum from roof  


[[Gastrointestinal_Tract_-_Liver_Development|Liver Development]] septum transversum forming liver stroma and hepatic diverticulum forming hepatic trabeculae<ref><pubmed>9407542</pubmed></ref>
{{Liver}} septum transversum forming liver stroma and hepatic diverticulum forming hepatic trabeculae{{#pmid:9407542|PMID9407542}}


[[Neural_System_Development|Neural]] - caudal neuropore takes a day to close (closure is approximately at future somitic pair 31/sacral vertebra 2)  
{{Neural}} - caudal neuropore takes a day to close (closure is approximately at future somitic pair 31/sacral vertebra 2)  


[[Neural_System_Development|Neural]] -  secondary neurulation begins  
{{Neural}} -  secondary neurulation begins  


[[Neural_Crest_Development|Neural Crest]] - cardiac crest, neural crest from rhombomeres 6 and 7 that migrates to pharyngeal arch 3 and from there the truncus arteriosus<ref><pubmed>17848161</pubmed></ref>
{{Neural crest}} - cardiac crest, neural crest from rhombomeres 6 and 7 that migrates to pharyngeal arch 3 and from there the truncus arteriosus{{#pmid:17848161|PMID17848161}}


[[Neural_Crest_Development|Neural Crest]] - vagal neural crest enter the foregut (20-25 somite stage)
{{Neural crest}} - vagal neural crest enter the foregut (20-25 somite stage)


|-
|-
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| <center>28</center>
| <center>28</center>
| [[Carnegie_stage_13|Stage 13]]
| [[Carnegie_stage_13|Stage 13]]
| [[File:Stage13_bf1c.jpg|200px|link=Carnegie stage 13]] [[Neural_System_Development|Neural]] -  the neural tube is normally completely closed, ventricular system now separated from amniotic fluid. Neural crest at spinal level is segregating, and spinal ganglia are in series with the somites. Spinal cord ventral roots beginning to develop.<ref><pubmed>3354839</pubmed></ref>
| [[File:Stage13_bf1c.jpg|200px|link=Carnegie stage 13]] [[Neural_System_Development|Neural]] -  the neural tube is normally completely closed, ventricular system now separated from amniotic fluid. Neural crest at spinal level is segregating, and spinal ganglia are in series with the somites. Spinal cord ventral roots beginning to develop.{{#pmid:3354839|PMID3354839}}


telencephalon cavity appears  
telencephalon cavity appears  


[[Gastrointestinal_Tract_-_Liver_Development|Liver Development]] epithelial cord proliferation enmeshing stromal capillaries<ref><pubmed>9407542</pubmed></ref>
{{Liver}} epithelial cord proliferation enmeshing stromal capillaries{{#pmid:9407542|PMID9407542}}


[[Sensory_-_Smell_Development|Sense - Smell]] Crest comes from the nasal plates<ref><pubmed>15604533</pubmed></ref>
{{Smell}} Crest comes from the nasal placodes{{#pmid:15604533|PMID15604533}}


[[Integumentary_System_Development|Skin]] - 4 weeks simple ectoderm epithelium over mesenchyme  
{{Integumentary}} - 4 weeks simple ectoderm epithelium over mesenchyme  


[[Integumentary_System_Development|Skin]] - 1 to 3 months ectoderm - germinative (basal) cell repeated division of generates stratified epithelium; mesoderm - differentiates into connective tissue and blood vessels
{{Integumentary}} - 1 to 3 months ectoderm - germinative (basal) cell repeated division of generates stratified epithelium; mesoderm - differentiates into connective tissue and blood vessels
|-
| colspan=3|Note - the day timing of stages is only approximate, system names link to first page of that specific system, and events are based upon the literature cited below.
|-
|-
| colspan=3|'''References'''
| colspan=3|'''References'''

Latest revision as of 09:56, 26 July 2019

Week 4 - Human Embryo Stages and Events (GA week 6) 
Embryo Week: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9
Day
Stage
Event
22
Stage 10 Stage10 dorsal1.jpg Stage10-dorsal2.jpg

neural crest - differentiation at spinal cord level from day 22 until day 26

neural - neural folds begin to fuse near the junction between brain and spinal cord, when neural crest - cells are arising mainly from the neural ectoderm

neural crest - trigeminal, facial, and postotic ganglia components visible[1]

neural crest - migration of vagal level neural crest cells begins (7-10 somite stage)

neural - Brain rostral neural tube forms 3 primary brain vesicles (week 4)

respiratory - Week 4 laryngotracheal groove forms on floor foregut.

23
  heart - begins to beat in Humans by day 22-23, first functioning embryonic organ formed.
24
Stage 11 Stage11 bf1c.jpg

thyroid - thyroid median endodermal thickening in the floor of pharynx

neural - rostral (or cephalic) neuropore closes within a few hours; closure is bidirectional, it takes place from the dorsal and terminal lips and may occur in two areas simultaneously. The two lips, however, behave differently.

Optic ventricle appears

25
Stage 12 Stage12 bf1c.jpg

pituitary - Week 4 hypophysial pouch, Rathke's pouch, diverticulum from roof

liver septum transversum forming liver stroma and hepatic diverticulum forming hepatic trabeculae[2]

neural - caudal neuropore takes a day to close (closure is approximately at future somitic pair 31/sacral vertebra 2)

neural - secondary neurulation begins

neural crest - cardiac crest, neural crest from rhombomeres 6 and 7 that migrates to pharyngeal arch 3 and from there the truncus arteriosus[1]

neural crest - vagal neural crest enter the foregut (20-25 somite stage)

26
   
27
   
28
Stage 13 Stage13 bf1c.jpg Neural - the neural tube is normally completely closed, ventricular system now separated from amniotic fluid. Neural crest at spinal level is segregating, and spinal ganglia are in series with the somites. Spinal cord ventral roots beginning to develop.[3]

telencephalon cavity appears

liver epithelial cord proliferation enmeshing stromal capillaries[2]

smell Crest comes from the nasal placodes[4]

integumentary - 4 weeks simple ectoderm epithelium over mesenchyme

integumentary - 1 to 3 months ectoderm - germinative (basal) cell repeated division of generates stratified epithelium; mesoderm - differentiates into connective tissue and blood vessels

Note - the day timing of stages is only approximate, system names link to first page of that specific system, and events are based upon the literature cited below.
References
  1. 1.0 1.1 O'Rahilly R & Müller F. (2007). The development of the neural crest in the human. J. Anat. , 211, 335-51. PMID: 17848161 DOI.
  2. 2.0 2.1 Godlewski G, Gaubert-Cristol R, Rouy S & Prudhomme M. (1997). Liver development in the rat and in man during the embryonic period (Carnegie stages 11-23). Microsc. Res. Tech. , 39, 314-27. PMID: 9407542 <314::AID-JEMT2>3.0.CO;2-H DOI.
  3. Müller F & O'Rahilly R. (1988). The development of the human brain from a closed neural tube at stage 13. Anat. Embryol. , 177, 203-24. PMID: 3354839
  4. Müller F & O'Rahilly R. (2004). Olfactory structures in staged human embryos. Cells Tissues Organs (Print) , 178, 93-116. PMID: 15604533 DOI.