Template:Valproic Acid Teratogenic Dose table

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Valproic Acid Species Difference for Teratogenic Dose (lowest) mg/kg/day
Species Neural tube defects Skeletal defects Route
Human 30 20-30 Oral
monkey not observed 150 oral
rabbit not observed 150 oral
rat not observed 150 oral
hamster 300 not investigated ip
mouse 200 200, 250, 400 ip, sc, oral
Table Data[1]    Links: valproic acid | drugs
  1. Nau H. (1986). Species differences in pharmacokinetics and drug teratogenesis. Environ. Health Perspect. , 70, 113-29. PMID: 3104022