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A single mutation in the prM protein of Zika virus contributes to fetal microcephaly
- "Here, we show that a single serine to asparagine substitution (S139N) in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs), led to more significant microcephaly in the mouse fetus, and higher mortality in neonatal mice. Evolutionary analysis indicates that the S139N substitution arose before the 2013 outbreak in French Polynesia and has been stably maintained during subsequent spread to the Americas. "
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly Science 28 Sep 2017
- Links: Zika Virus
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