Template:Leptin table
From Embryology
Leptin effects on female reproduction | |||
---|---|---|---|
Target Tissue | Biological Process | Biological Function | Mechanism |
Hypothalamus | GnRH secretion | Regulation of LH and FSH secretion | Indirectly via kisspeptin |
Pituitary | Estrous cycles and ovulation | FSH and LH release; LH plasticity and cyclicity | |
Ovary | Ovarian steroidogenesis | Estrogen production | P450 aromatase; P450-17α hydroxylase |
Ovary | Folliculogenesis | Low leptin promotes follicle development | Promotes the transition of primordial to primary follicles |
Embryo | Embryogenesis | Biophysical effect on embryo growth and quality | Stimulates proliferation |
Uterus | Angiogenesis | Stimulates metalloproteinase activity | Inhibits terminal differentiation of committed giant cells |
Table modified from:<pubmed>24908087</pubmed> |