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'''T= 0'''   Fertilisation
<gallery caption="Development of the Mouse Embryo" widths="175px" heights="175px" perrow="5">
 
File:Day 0 one cell stage.jpg|'''Day 0''' One Cell Egg
'''T=1'''   Cleavage of cells has begun. Day ends with 4 cells present
File:Day 1 dividing egg.JPG|'''Day 1''' Dividing Egg. Cleavage of cells has begun. The Day ends with 4 cells present.
 
File:Day 2 morula.JPG|'''Day 2''' Morula
'''T=2'''   Formation of Morula
File:Day 3 Advanced Segmentation.JPG|'''Day 3''' Advanced segmentation of the Morula. 16-25 cells within same sized morula.
 
File:Day 4 Blastocyst.JPG|'''Day 4''' Blastocyst formation
'''T=3'''   Compaction of morula. 16-25 cells within same sized morula.  
File:Day 4.5 Implantation.JPG|'''Day 4.5''' Implantation and Invasion of the blastocyst into the uterine epithelium
 
File:Day 5 Formation of Egg Cylinder.JPG|'''Day 5''' Formation of the egg cylinder
'''T=4'''   Blastocyst formation
File:Day 6 Differentiation of Egg Cylinder.JPG|'''Day 6''' Differentiation of the egg cylinder
 
File:Day 6.5 Advanced Endometrial Reaction.JPG|'''Day 6.5''' Gastrulation starts during the period of Advanced Endometrial Reaction
'''T= 4.5'''   Implantation and invasion into the uterine epithelium
File:Day 7 Amnion.JPG|'''Day 7''' Amnion formation
 
File:Day 7.5 Neural plate, presomite stage.JPG|'''Day 7.5''' Neural plate and presomite stage
'''T=5'''   Embryoblast and trophoblast formation. Endometrial reaction occurs
File:Day 8 First Somites.JPG|'''Day 8''' Formation of the first seven somites.  
 
File:Day 8.5 Turning of embryo.JPG|'''Day 8.5''' Rotation of the embryo. The embryo now has between 8 and 12 somites.
'''T=6'''   Embryoblast begins to divide into embryonic and extramembryonic cavities. The proamniotic cavity also starts to form. Trophoblast cells also begin to differentiate
File:Day 9 Formation and closure of anterior neuropore.JPG|'''Day 9''' Formation and closure of the anterior neuropore. There are 13 - 20 somites present in the embryo
 
File:Day 9.5 Formation of posterior neuropore and forelimb bud.JPG|'''Day 9.5''' Formation of the posterior neuropore and forelimb bud. There are 21 to 29 somites present and the embryo measures 1.8 - 3.3 mm in length.
'''T=6.5'''   Axis of embryonic germ disc is defined. Uterine reaction (decidual reaction) occurs.  
file:Day 10 Closure of posterior neuropore, hind limb bud and tail bud.JPG|'''Day 10''' The posterior neuropore closes and formation of the hind limb bud and tail bud occurs. there are 30 - 34 somites present and the embryo is 3.1 - 3.9mm
 
File:Day 10.5 Deep Lens Indentation.JPG|'''Day 10.5''' Deep eye lens indentation occurs. There are 35-30 somites present and the embryo is now 3.5-4.9mm.
'''T=7'''   Formulation of amnion occurs. Formation of mesoderm, entoderm and endometrium also occur.  
File:Day 11 Closure of lens vesicle.JPG|'''Day 11''' Closure of the lens vesicle. There are 40-44 somites present and the embryo has reached 5-6mm in length.
 
File:Day 11.5 Lens Vesicle completely separated from surface.JPG|'''Day 11.5''' The lens vesicle is completely separated from the surface epithelium. There are currently 45 - 47 somites and the embryo reaches a length of 6 - 7mm
'''T=7 ½'''   Closure of the amnion. The neural plate is clearly delimited anteriorly and laterally. The head process is now developing. Foregut development begins. Blood islands develop in the wall of the yolk sac.
File:Day 12 Earliest signs of fingers.JPG|'''Day 12''' First signs of fingers. The embryo is 7 - 9mm in length from crown to rump and there are 48 - 51 somites.  
 
File:Day 13 Anterior Footplate Indented, marked pinna.JPG|'''Day 13''' The anterior footplate becomes indented and the external ear structure is more defined. The embryo is now 9 - 11mm in length and has 52 - 55 somites.  
'''T= 8'''   Embryo has 1-7 somites present. Progressive deepening of the neural tube. Circulatory system development begins. Intestinal tract development continues. Central nervous system development begins. Extraembryonic membranes grow and begin to fuse. Yolk sac continues to enlarge.  
File:Day 14 Fingers Separate.JPG|'''Day 14''' The fingers separate. The embryo has 56 - 66 somites and is 11-12mm in length.
 
File:Day 15 toes separate.JPG|'''Day 15''' The toes separate. At this stage the embryo is 12 - 14.4m from crown to rump
'''T=8 ½'''   8-12 somites present. rotation of embryo occurs. The turning of the embryo occurs.  
File:Day 16 Reposition of umbilical hernia.JPG|'''Day 16''' The umbilical hernia is repositioned. The fetus now measures between 14 and 17 mm.
 
File:Day 17 fingers and toes joined together.JPG|'''Day 17''' The fingers and toes become joined together. The skin is wrinkled and thickened and the umbilical hernia has disappeared. The fetus measures 16.5 - 20mm depending on the degree of curvature.
'''T=9'''   13-20 somites present. Turning of the embryo has completed. Central nervous system development  occurs. The circulatory system and intestinal tract development continues. The urogenital system development begins. Placenta development begins.  
File:Day 18 long whiskers.JPG|'''Day 18''' Whiskers elongate. The length of the embryo varies between 18 and 23 mm due to the degree of curvature of the fetus.
 
File:Day 19 Newborn Mouse.JPG|'''Day 19''' The newborn mouse is between 23 and 27mm depending on the degree of flexure of the body axis
'''T= 9 ½'''   21-29 somites present. The embryo is 1.8-3.3 mm. Cardiovascular, CNS, Intestinal and urogenital development continue. Condensation of forelimb bud occurs.
</gallery>

Latest revision as of 18:32, 14 October 2009

  • Development of the Mouse Embryo
  • Day 0 One Cell Egg

    Day 0 One Cell Egg

  • Day 1 Dividing Egg. Cleavage of cells has begun. The Day ends with 4 cells present.

    Day 1 Dividing Egg. Cleavage of cells has begun. The Day ends with 4 cells present.

  • Day 2 Morula

    Day 2 Morula

  • Day 3 Advanced segmentation of the Morula. 16-25 cells within same sized morula.

    Day 3 Advanced segmentation of the Morula. 16-25 cells within same sized morula.

  • Day 4 Blastocyst formation

    Day 4 Blastocyst formation

  • Day 4.5 Implantation and Invasion of the blastocyst into the uterine epithelium

    Day 4.5 Implantation and Invasion of the blastocyst into the uterine epithelium

  • Day 5 Formation of the egg cylinder

    Day 5 Formation of the egg cylinder

  • Day 6 Differentiation of the egg cylinder

    Day 6 Differentiation of the egg cylinder

  • Day 6.5 Gastrulation starts during the period of Advanced Endometrial Reaction

    Day 6.5 Gastrulation starts during the period of Advanced Endometrial Reaction

  • Day 7 Amnion formation

    Day 7 Amnion formation

  • Day 7.5 Neural plate and presomite stage

    Day 7.5 Neural plate and presomite stage

  • Day 8 Formation of the first seven somites.

    Day 8 Formation of the first seven somites.

  • Day 8.5 Rotation of the embryo. The embryo now has between 8 and 12 somites.

    Day 8.5 Rotation of the embryo. The embryo now has between 8 and 12 somites.

  • Day 9 Formation and closure of the anterior neuropore. There are 13 - 20 somites present in the embryo

    Day 9 Formation and closure of the anterior neuropore. There are 13 - 20 somites present in the embryo

  • Day 9.5 Formation of the posterior neuropore and forelimb bud. There are 21 to 29 somites present and the embryo measures 1.8 - 3.3 mm in length.

    Day 9.5 Formation of the posterior neuropore and forelimb bud. There are 21 to 29 somites present and the embryo measures 1.8 - 3.3 mm in length.

  • Day 10 The posterior neuropore closes and formation of the hind limb bud and tail bud occurs. there are 30 - 34 somites present and the embryo is 3.1 - 3.9mm

    Day 10 The posterior neuropore closes and formation of the hind limb bud and tail bud occurs. there are 30 - 34 somites present and the embryo is 3.1 - 3.9mm

  • Day 10.5 Deep eye lens indentation occurs. There are 35-30 somites present and the embryo is now 3.5-4.9mm.

    Day 10.5 Deep eye lens indentation occurs. There are 35-30 somites present and the embryo is now 3.5-4.9mm.

  • Day 11 Closure of the lens vesicle. There are 40-44 somites present and the embryo has reached 5-6mm in length.

    Day 11 Closure of the lens vesicle. There are 40-44 somites present and the embryo has reached 5-6mm in length.

  • Day 11.5 The lens vesicle is completely separated from the surface epithelium. There are currently 45 - 47 somites and the embryo reaches a length of 6 - 7mm

    Day 11.5 The lens vesicle is completely separated from the surface epithelium. There are currently 45 - 47 somites and the embryo reaches a length of 6 - 7mm

  • Day 12 First signs of fingers. The embryo is 7 - 9mm in length from crown to rump and there are 48 - 51 somites.

    Day 12 First signs of fingers. The embryo is 7 - 9mm in length from crown to rump and there are 48 - 51 somites.

  • Day 13 The anterior footplate becomes indented and the external ear structure is more defined. The embryo is now 9 - 11mm in length and has 52 - 55 somites.

    Day 13 The anterior footplate becomes indented and the external ear structure is more defined. The embryo is now 9 - 11mm in length and has 52 - 55 somites.

  • Day 14 The fingers separate. The embryo has 56 - 66 somites and is 11-12mm in length.

    Day 14 The fingers separate. The embryo has 56 - 66 somites and is 11-12mm in length.

  • Day 15 The toes separate. At this stage the embryo is 12 - 14.4m from crown to rump

    Day 15 The toes separate. At this stage the embryo is 12 - 14.4m from crown to rump

  • Day 16 The umbilical hernia is repositioned. The fetus now measures between 14 and 17 mm.

    Day 16 The umbilical hernia is repositioned. The fetus now measures between 14 and 17 mm.

  • Day 17 The fingers and toes become joined together. The skin is wrinkled and thickened and the umbilical hernia has disappeared. The fetus measures 16.5 - 20mm depending on the degree of curvature.

    Day 17 The fingers and toes become joined together. The skin is wrinkled and thickened and the umbilical hernia has disappeared. The fetus measures 16.5 - 20mm depending on the degree of curvature.

  • Day 18 Whiskers elongate. The length of the embryo varies between 18 and 23 mm due to the degree of curvature of the fetus.

    Day 18 Whiskers elongate. The length of the embryo varies between 18 and 23 mm due to the degree of curvature of the fetus.

  • Day 19 The newborn mouse is between 23 and 27mm depending on the degree of flexure of the body axis

    Day 19 The newborn mouse is between 23 and 27mm depending on the degree of flexure of the body axis

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