Difference between revisions of "Template:Frog Cornea Timeline table"

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Frog Cornea Timeline
Stage Event
stage 25 cornea starts from a simple embryonic epidermis overlying the developing optic vesicle.
stage 30 detachment of the lens placode, cranial neural crest cells start to invade the space between the lens and the embryonic epidermis to construct the corneal endothelium.
stage 41 a second wave of migratory cells containing presumptive keratocytes invades the matrix leading to the formation of inner cornea and outer cornea. A unique cell mass (stroma attracting center) connects the two layers like the center pole of a tent.
stage 48 many secondary stromal keratocytes individually migrate to the center and form the stroma layer.
stage 60 the stroma space is filled by collagen lamellae and keratocytes, and the stroma attracting center disappears. At early metamorphosis, the embryonic epithelium gradually changes to the adult corneal epithelium, which is covered by microvilli.
stage 62 the embryonic epithelium thickens and cell death is observed in the epithelium, coinciding with eyelid opening.
After metamorphosis cornea has attained the adult structure of three cellular layers, epithelium, stroma, and endothelium, and between the cellular layers lie two acellular layers (Bowman's layer and Descemet's membrane)
frog | vision
  1. 1.0 1.1 Hu W, Haamedi N, Lee J, Kinoshita T & Ohnuma S. (2013). The structure and development of Xenopus laevis cornea. Exp. Eye Res. , 116, 109-28. PMID: 23896054 DOI.