Template:Blastocyst Hippo table: Difference between revisions

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! Mouse blastocyst (32 cell stage)
! colspan=2|Mouse Blastocyst (32 cell stage) Fate
|-bgcolor="EDFF2"
|-bgcolor="CEDFF2"
| width=400px|phosphorylation of angiomotin at adherens junctions
width=400px| Inner cells
| width=400px|cell polarization sequesters Amot from basolateral adherens junctions
! width=400px| Outer cells
|-
|-
| active Hippo signaling
| Angiomotin (Amot) phosphorylation at adherens junctions
| inactive Hippo signaling
| Amot sequestered by cell polarization from basolateral adherens junctions
|-bgcolor="F5FAFF"
| Hippo active
| Hippo inactive
|-
|-
| inner cells
| Notch inactive
| outer cells
| Notch active
|-
|-
| inner cell mass (ICM) fate
| Cdx2 not expressed
| trophectoderm (TE) fate
| Cdx2 expressed
|-bgcolor="F5FAFF"
| '''ICM''' - inner cell mass fate
| '''TE''' - trophectoderm fate
|-
|-
| colspan=2|(Table data see review{{#pmid:25986053|PMID25986053}} Notch signaling also has a role in blastocyst fate development)
| colspan=2|
[[Developmental Signals - Hippo|Hippo]]{{#pmid:25986053|PMID25986053}}(TEAD4) and [[Developmental Signals - Notch|Notch]]{{#pmid:25127056|PMID25127056}}(Cdx2) together appear regulate early [[Blastocyst Development|blastocyst]] fate development.
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Latest revision as of 12:34, 21 March 2018

Mouse Blastocyst (32 cell stage) Fate
Inner cells Outer cells
Angiomotin (Amot) phosphorylation at adherens junctions Amot sequestered by cell polarization from basolateral adherens junctions
Hippo active Hippo inactive
Notch inactive Notch active
Cdx2 not expressed Cdx2 expressed
ICM - inner cell mass fate TE - trophectoderm fate

Hippo[1](TEAD4) and Notch[2](Cdx2) together appear regulate early blastocyst fate development.

  1. Sasaki H. (2015). Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation mouse embryos. Semin. Cell Dev. Biol. , 47-48, 80-7. PMID: 25986053 DOI.
  2. Rayon T, Menchero S, Nieto A, Xenopoulos P, Crespo M, Cockburn K, Cañon S, Sasaki H, Hadjantonakis AK, de la Pompa JL, Rossant J & Manzanares M. (2014). Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst. Dev. Cell , 30, 410-22. PMID: 25127056 DOI.