Template:Blastocyst Hippo table: Difference between revisions
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! Mouse | ! colspan=2|Mouse Blastocyst (32 cell stage) Fate | ||
|-bgcolor=" | |-bgcolor="CEDFF2" | ||
! width=400px| Inner cells | |||
! width=400px| Outer cells | |||
|- | |- | ||
| active | | Angiomotin (Amot) phosphorylation at adherens junctions | ||
| inactive | | Amot sequestered by cell polarization from basolateral adherens junctions | ||
|-bgcolor="F5FAFF" | |||
| Hippo active | |||
| Hippo inactive | |||
|- | |- | ||
| | | Notch inactive | ||
| | | Notch active | ||
|- | |- | ||
| inner cell mass | | Cdx2 not expressed | ||
| trophectoderm | | Cdx2 expressed | ||
|-bgcolor="F5FAFF" | |||
| '''ICM''' - inner cell mass fate | |||
| '''TE''' - trophectoderm fate | |||
|- | |- | ||
| colspan=2| | | colspan=2| | ||
[[Developmental Signals - Hippo|Hippo]]{{#pmid:25986053|PMID25986053}}(TEAD4) and [[Developmental Signals - Notch|Notch]]{{#pmid:25127056|PMID25127056}}(Cdx2) together appear regulate early [[Blastocyst Development|blastocyst]] fate development. | |||
|} | |} |
Latest revision as of 12:34, 21 March 2018
Mouse Blastocyst (32 cell stage) Fate | |
---|---|
Inner cells | Outer cells |
Angiomotin (Amot) phosphorylation at adherens junctions | Amot sequestered by cell polarization from basolateral adherens junctions |
Hippo active | Hippo inactive |
Notch inactive | Notch active |
Cdx2 not expressed | Cdx2 expressed |
ICM - inner cell mass fate | TE - trophectoderm fate |
Hippo[1](TEAD4) and Notch[2](Cdx2) together appear regulate early blastocyst fate development. |
- ↑ Sasaki H. (2015). Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation mouse embryos. Semin. Cell Dev. Biol. , 47-48, 80-7. PMID: 25986053 DOI.
- ↑ Rayon T, Menchero S, Nieto A, Xenopoulos P, Crespo M, Cockburn K, Cañon S, Sasaki H, Hadjantonakis AK, de la Pompa JL, Rossant J & Manzanares M. (2014). Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst. Dev. Cell , 30, 410-22. PMID: 25127056 DOI.