Template:Blastocyst Hippo table: Difference between revisions
From Embryology
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| Angiomotin (Amot) phosphorylation at adherens junctions | | Angiomotin (Amot) phosphorylation at adherens junctions | ||
| Amot sequestered by cell polarization from basolateral adherens junctions | | Amot sequestered by cell polarization from basolateral adherens junctions | ||
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| Hippo active | | Hippo active | ||
| Hippo inactive | | Hippo inactive | ||
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| Notch inactive | | Notch inactive | ||
| Notch active | | Notch active | ||
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| Cdx2 not expressed | |||
| Cdx2 expressed | |||
|-bgcolor="F5FAFF" | |-bgcolor="F5FAFF" | ||
| '''ICM''' - inner cell mass fate | | '''ICM''' - inner cell mass fate | ||
Revision as of 11:29, 21 March 2018
| Mouse Blastocyst (32 cell stage) Fate | |
|---|---|
| Inner cells | Outer cells |
| Angiomotin (Amot) phosphorylation at adherens junctions | Amot sequestered by cell polarization from basolateral adherens junctions |
| Hippo active | Hippo inactive |
| Notch inactive | Notch active |
| Cdx2 not expressed | Cdx2 expressed |
| ICM - inner cell mass fate | TE - trophectoderm fate |
| Hippo[1](TEAD4) and Notch[2](Cdx2) together appear regulate early blastocyst fate development. | |
- ↑ Sasaki H. (2015). Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation mouse embryos. Semin. Cell Dev. Biol. , 47-48, 80-7. PMID: 25986053 DOI.
- ↑ Rayon T, Menchero S, Nieto A, Xenopoulos P, Crespo M, Cockburn K, Cañon S, Sasaki H, Hadjantonakis AK, de la Pompa JL, Rossant J & Manzanares M. (2014). Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst. Dev. Cell , 30, 410-22. PMID: 25127056 DOI.
