Talk:Worm Development

Neurogenesis in the nematode Caenorhabditis elegans

Hobert O. WormBook. 2010 Oct 4:1-24.

Abstract The nervous system represents the most complex tissue of C. elegans both in terms of numbers (302 neurons and 56 glial cells = 37% of the somatic cells in a hermaphrodite) and diversity (118 morphologically distinct neuron classes). The lineage and morphology of each neuron type has been described in detail and neuronal fate markers exists for virtually all neurons in the form of fluorescent reporter genes. The ability to "phenotype" neurons at high resolution combined with the amenability of C. elegans to genetic mutant analysis make the C. elegans nervous system a prime model system to elucidate the nature of the gene regulatory programs that build a nervous system-a central question of developmental neurobiology. Discussing a number of regulatory genes involved in neuronal lineage determination and neuronal differentiation, I will try to carve out in this review a few general principles of neuronal development in C. elegans. These principles may be conserved across phylogeny.

PMID: 20891032

http://www.ncbi.nlm.nih.gov/pubmed/20891032

http://www.wormbook.org/chapters/www_specnervsys.2/neurogenesis.html

Spermatogenesis-Specific Features of the Meiotic Program in Caenorhabditis elegans

http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000611

Chromosome axis defects induce a checkpoint-mediated delay and interchromosomal effect on crossing over during Drosophila meiosis

Joyce EF, McKim KS. PLoS Genet. 2010 Aug 12;6(8). pii: e1001059. PMID: 20711363

http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1001059

xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor TRA-1

Hargitai B, Kutnyánszky V, Blauwkamp TA, Steták A, Csankovszki G, Takács-Vellai K, Vellai T. Development. 2009 Dec;136(23):3881-7. PMID: 19906855

"In the nematode Caenorhabditis elegans, sex is determined by the ratio of X chromosomes to sets of autosomes: XX animals (2X:2A=1.0) develop as hermaphrodites and XO animals (1X:2A=0.5) develop as males. ....Here we identify a consensus TRA-1 binding site in the regulatory region of xol-1, the master switch gene controlling sex determination and dosage compensation. xol-1 is normally expressed in males, where it promotes male development and prevents dosage compensation."

• Somatic sexual differentiation in Caenorhabditis elegans. Wolff JR, Zarkower D. Curr Top Dev Biol. 2008;83:1-39. PMID: 19118662
• The primary sex determination signal of Caenorhabditis elegans. Carmi I, Meyer BJ. Genetics. 1999 Jul;152(3):999-1015. PMID: 10388819

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