Talk:Worm Development: Difference between revisions

Revision as of 02:43, 18 July 2010

Spermatogenesis-Specific Features of the Meiotic Program in Caenorhabditis elegans

http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000611

Sex Determination

xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor TRA-1. Hargitai B, Kutnyánszky V, Blauwkamp TA, Steták A, Csankovszki G, Takács-Vellai K, Vellai T. Development. 2009 Dec;136(23):3881-7. PMID: 19906855

"In the nematode Caenorhabditis elegans, sex is determined by the ratio of X chromosomes to sets of autosomes: XX animals (2X:2A=1.0) develop as hermaphrodites and XO animals (1X:2A=0.5) develop as males. ....Here we identify a consensus TRA-1 binding site in the regulatory region of xol-1, the master switch gene controlling sex determination and dosage compensation. xol-1 is normally expressed in males, where it promotes male development and prevents dosage compensation."

Somatic sexual differentiation in Caenorhabditis elegans. Wolff JR, Zarkower D. Curr Top Dev Biol. 2008;83:1-39. PMID: 19118662
The primary sex determination signal of Caenorhabditis elegans. Carmi I, Meyer BJ. Genetics. 1999 Jul;152(3):999-1015. PMID: 10388819

@@ Line 1: / Line 1: @@
+Spermatogenesis-Specific Features of the Meiotic Program in Caenorhabditis elegans
+http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000611
 ==Sex Determination==
 * xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor TRA-1. Hargitai B, Kutnyánszky V, Blauwkamp TA, Steták A, Csankovszki G, Takács-Vellai K, Vellai T. Development. 2009 Dec;136(23):3881-7. [http://www.ncbi.nlm.nih.gov/pubmed/19906855?dopt=Abstract PMID: 19906855]