Talk:Vision - Lens Development: Difference between revisions

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==2011==
===Neural crest cells organize the eye via TGF-β and canonical Wnt signalling===
Nat Commun. 2011 Apr;2:265.
Grocott T, Johnson S, Bailey AP, Streit A.
Source
Department of Craniofacial Development, King's College London, Guy's Campus, London SE1 9RT, UK.
Abstract
In vertebrates, the lens and retina arise from different embryonic tissues raising the question of how they are aligned to form a functional eye. Neural crest cells are crucial for this process: in their absence, ectopic lenses develop far from the retina. Here we show, using the chick as a model system, that neural crest-derived transforming growth factor-βs activate both Smad3 and canonical Wnt signalling in the adjacent ectoderm to position the lens next to the retina. They do so by controlling Pax6 activity: although Smad3 may inhibit Pax6 protein function, its sustained downregulation requires transcriptional repression by Wnt-initiated β-catenin. We propose that the same neural crest-dependent signalling mechanism is used repeatedly to integrate different components of the eye and suggest a general role for the neural crest in coordinating central and peripheral parts of the sensory nervous system.
PMID: 21468017
http://www.ncbi.nlm.nih.gov/pubmed/21468017
http://www.nature.com/ncomms/journal/v2/n4/full/ncomms1269.html
==2007==
===Genetic and epigenetic mechanisms of gene regulation during lens development===
===Genetic and epigenetic mechanisms of gene regulation during lens development===
Cvekl A, Duncan MK.
Cvekl A, Duncan MK.

Revision as of 15:28, 29 April 2011

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Cite this page: Hill, M.A. (2024, March 29) Embryology Vision - Lens Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Vision_-_Lens_Development

2011

Neural crest cells organize the eye via TGF-β and canonical Wnt signalling

Nat Commun. 2011 Apr;2:265.

Grocott T, Johnson S, Bailey AP, Streit A. Source Department of Craniofacial Development, King's College London, Guy's Campus, London SE1 9RT, UK.

Abstract

In vertebrates, the lens and retina arise from different embryonic tissues raising the question of how they are aligned to form a functional eye. Neural crest cells are crucial for this process: in their absence, ectopic lenses develop far from the retina. Here we show, using the chick as a model system, that neural crest-derived transforming growth factor-βs activate both Smad3 and canonical Wnt signalling in the adjacent ectoderm to position the lens next to the retina. They do so by controlling Pax6 activity: although Smad3 may inhibit Pax6 protein function, its sustained downregulation requires transcriptional repression by Wnt-initiated β-catenin. We propose that the same neural crest-dependent signalling mechanism is used repeatedly to integrate different components of the eye and suggest a general role for the neural crest in coordinating central and peripheral parts of the sensory nervous system.

PMID: 21468017 http://www.ncbi.nlm.nih.gov/pubmed/21468017

http://www.nature.com/ncomms/journal/v2/n4/full/ncomms1269.html

2007

Genetic and epigenetic mechanisms of gene regulation during lens development

Cvekl A, Duncan MK. Prog Retin Eye Res. 2007 Nov;26(6):555-97. Epub 2007 Jul 28. Review.

Recent studies demonstrated a number of links between chromatin structure, gene expression, extracellular signaling and cellular differentiation during lens development. Lens progenitor cells originate from a pool of common progenitor cells, the pre-placodal region (PPR) which is formed from a combination of extracellular signaling between the neural plate, naïve ectoderm and mesendoderm. A specific commitment to the lens program over alternate choices such as the formation of olfactory epithelium or the anterior pituitary is manifested by the formation of a thickened surface ectoderm, the lens placode. Mouse lens progenitor cells are characterized by the expression of a complement of lens lineage-specific transcription factors including Pax6, Six3 and Sox2, controlled by FGF and BMP signaling, followed later by c-Maf, Mab21like1, Prox1 and FoxE3. Proliferation of lens progenitors together with their morphogenetic movements results in the formation of the lens vesicle. This transient structure, comprised of lens precursor cells, is polarized with its anterior cells retaining their epithelial morphology and proliferative capacity, whereas the posterior lens precursor cells initiate terminal differentiation forming the primary lens fibers. Lens differentiation is marked by expression and accumulation of crystallins and other structural proteins. The transcriptional control of crystallin genes is characterized by the reiterative use of transcription factors required for the establishment of lens precursors in combination with more ubiquitously expressed factors (e.g. AP-1, AP-2alpha, CREB and USF) and recruitment of histone acetyltransferases (HATs) CBP and p300, and chromatin remodeling complexes SWI/SNF and ISWI. These studies have poised the study of lens development at the forefront of efforts to understand the connections between development, cell signaling, gene transcription and chromatin remodeling.

PMID: 17905638 http://www.ncbi.nlm.nih.gov/pubmed/17905638

Lens induction in vertebrates: variations on a conserved theme of signaling events

Donner AL, Lachke SA, Maas RL. Semin Cell Dev Biol. 2006 Dec;17(6):676-85. Epub 2006 Oct 27. Review. PMID: 17164096

Growth factor regulation of lens development

Lovicu FJ, McAvoy JW. Dev Biol. 2005 Apr 1;280(1):1-14. Review. PMID: 15766743


PMID: 18782574

A network of capillaries branches from the hyaloid vascular system and surrounds the mammalian lens throughout much of its embryonic development. These vessels are presumed to be important for the growth and maturation of the lens, although the lenses of non-mammalian vertebrates have no comparable vessels.


PMID: 8641842

http://www.iovs.org/cgi/reprint/37/7/1396