Talk:Vision - Lens Development: Difference between revisions
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===Genetic and epigenetic mechanisms of gene regulation during lens development=== | |||
Cvekl A, Duncan MK. | |||
Prog Retin Eye Res. 2007 Nov;26(6):555-97. Epub 2007 Jul 28. Review. | |||
Recent studies demonstrated a number of links between chromatin structure, gene expression, extracellular signaling and cellular differentiation during lens development. Lens progenitor cells originate from a pool of common progenitor cells, the pre-placodal region (PPR) which is formed from a combination of extracellular signaling between the neural plate, naïve ectoderm and mesendoderm. A specific commitment to the lens program over alternate choices such as the formation of olfactory epithelium or the anterior pituitary is manifested by the formation of a thickened surface ectoderm, the lens placode. Mouse lens progenitor cells are characterized by the expression of a complement of lens lineage-specific transcription factors including Pax6, Six3 and Sox2, controlled by FGF and BMP signaling, followed later by c-Maf, Mab21like1, Prox1 and FoxE3. Proliferation of lens progenitors together with their morphogenetic movements results in the formation of the lens vesicle. This transient structure, comprised of lens precursor cells, is polarized with its anterior cells retaining their epithelial morphology and proliferative capacity, whereas the posterior lens precursor cells initiate terminal differentiation forming the primary lens fibers. Lens differentiation is marked by expression and accumulation of crystallins and other structural proteins. The transcriptional control of crystallin genes is characterized by the reiterative use of transcription factors required for the establishment of lens precursors in combination with more ubiquitously expressed factors (e.g. AP-1, AP-2alpha, CREB and USF) and recruitment of histone acetyltransferases (HATs) CBP and p300, and chromatin remodeling complexes SWI/SNF and ISWI. These studies have poised the study of lens development at the forefront of efforts to understand the connections between development, cell signaling, gene transcription and chromatin remodeling. | |||
PMID: 17905638 | |||
http://www.ncbi.nlm.nih.gov/pubmed/17905638 | |||
===Lens induction in vertebrates: variations on a conserved theme of signaling events=== | |||
Donner AL, Lachke SA, Maas RL. | |||
Semin Cell Dev Biol. 2006 Dec;17(6):676-85. Epub 2006 Oct 27. Review. | |||
PMID: 17164096 | |||
===Growth factor regulation of lens development=== | |||
Lovicu FJ, McAvoy JW. | |||
Dev Biol. 2005 Apr 1;280(1):1-14. Review. | |||
PMID: 15766743 | |||
PMID: 18782574 | PMID: 18782574 | ||
Revision as of 13:18, 13 October 2010
Genetic and epigenetic mechanisms of gene regulation during lens development
Cvekl A, Duncan MK. Prog Retin Eye Res. 2007 Nov;26(6):555-97. Epub 2007 Jul 28. Review.
Recent studies demonstrated a number of links between chromatin structure, gene expression, extracellular signaling and cellular differentiation during lens development. Lens progenitor cells originate from a pool of common progenitor cells, the pre-placodal region (PPR) which is formed from a combination of extracellular signaling between the neural plate, naïve ectoderm and mesendoderm. A specific commitment to the lens program over alternate choices such as the formation of olfactory epithelium or the anterior pituitary is manifested by the formation of a thickened surface ectoderm, the lens placode. Mouse lens progenitor cells are characterized by the expression of a complement of lens lineage-specific transcription factors including Pax6, Six3 and Sox2, controlled by FGF and BMP signaling, followed later by c-Maf, Mab21like1, Prox1 and FoxE3. Proliferation of lens progenitors together with their morphogenetic movements results in the formation of the lens vesicle. This transient structure, comprised of lens precursor cells, is polarized with its anterior cells retaining their epithelial morphology and proliferative capacity, whereas the posterior lens precursor cells initiate terminal differentiation forming the primary lens fibers. Lens differentiation is marked by expression and accumulation of crystallins and other structural proteins. The transcriptional control of crystallin genes is characterized by the reiterative use of transcription factors required for the establishment of lens precursors in combination with more ubiquitously expressed factors (e.g. AP-1, AP-2alpha, CREB and USF) and recruitment of histone acetyltransferases (HATs) CBP and p300, and chromatin remodeling complexes SWI/SNF and ISWI. These studies have poised the study of lens development at the forefront of efforts to understand the connections between development, cell signaling, gene transcription and chromatin remodeling.
PMID: 17905638 http://www.ncbi.nlm.nih.gov/pubmed/17905638
Lens induction in vertebrates: variations on a conserved theme of signaling events
Donner AL, Lachke SA, Maas RL. Semin Cell Dev Biol. 2006 Dec;17(6):676-85. Epub 2006 Oct 27. Review. PMID: 17164096
Growth factor regulation of lens development
Lovicu FJ, McAvoy JW. Dev Biol. 2005 Apr 1;280(1):1-14. Review. PMID: 15766743
PMID: 18782574
A network of capillaries branches from the hyaloid vascular system and surrounds the mammalian lens throughout much of its embryonic development. These vessels are presumed to be important for the growth and maturation of the lens, although the lenses of non-mammalian vertebrates have no comparable vessels.
PMID: 8641842
