Talk:Renal System - Molecular

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Cite this page: Hill, M.A. (2021, December 2) Embryology Renal System - Molecular. Retrieved from

Growth Factors Receptors

Fgfr1, Fgfr2 Fibroblast Growth Factor Receptor 1, 2 early metanephric development UB, MM

Gfrα1 GDNF Family Receptor Alpha 1 outgrowth of cells from the WD towards the MM UB, MM

Notch 2 Neurogenic locus notch homolog protein 2 maturation of proximal end of the nephron MM

Ret Receptor tyrosine-protein kinase initial ureteric bud outgrowth from Wolfian duct, interacts with GDNF ureteric bud epithelial cells

Transcription Factors

BRN1 Brain-Specific Homeobox/POU Domain Protein 1 tubule formation S-shaped body

FoxC2 Forkhead Box C2 first signal in podocyte commtiment s-shaped body

LIM1 (LHX1) LIM homebox 1 initial stages of patterning in the renal vesicle PTA, c-shaped body

Osr1 Odd-Skipped Related Transcription Factor 1 giving rise to MM intermediate mesoderm, MM

Sall1 Spalt-Like Transcription Factor 1 ensures high level of GDNF production MM

Pax2 Paired box gene 2 Expression in the MM ensures high level of GDNF production UB epithelial cells and condensed MM

Wt1 Wilms tumor 1 ensures high level of GDNF production cap MM-high levels, stromal MM-low levels, glomerular progenitors

Other Signals

β-catenin cadherin-associated protein beta nephron formation in the early stage of kidney development several cell types

Eya1 Eyes absent homolog 1 very early kidney development MM

HoxA11, HoxC11, HoxD11 homeobox protein A11, C11, D11 early kidney development uninduced MM

Six1 Sine oculis-related homeobox 1 early kidney development uninduced MM

Six2 Sine oculis-related homeobox 2 maintain nephron progenitor cells subpopulation of cells in cap MM