Talk:Renal System - Abnormalities: Difference between revisions

Revision as of 10:48, 3 June 2010

thought to be a deficiency in caudal mesoderm which in turn leads to the malformation of the urorectal septum and other structures in the pelvic region.
Recent research has also identified the potential presence of a persistent urachus prior to septation of the cloaca (common urogenital sinus).

associated with renal agenesis.

@@ Line 15: / Line 15: @@
 * Ureter - Duplex Ureter
 * Urethra- Urethral Obstruction and Hypospadias
-===Wilms' Tumor===
-* (nephroblastoma) Named after Max Wilms, a German doctor who wrote first medical articles 1899
-* most common type of kidney cancer children
-* WT1 gene - encodes a zinc finger protein
-* Both constitutional and somatic mutations disrupting the DNA-binding domain of WT1 result in a potentially dominant-negative phenotype
-* some blastema cells (mass of undifferentiated cells) persist to form a ‘nephrogenic rest’
-* Most rests become dormant or regress but others proliferate to form hyperplastic rests
-* any type of rest can then undergo a genetic or epigenetic change to become a neoplastic rest
-* can proliferate further to produce a benign lesion (adenomatous rest) or a malignant Wilms’ tumour