De novo synthesis of estrogen in pregnant uterus is critical for stromal decidualization and angiogenesis. Das A, Mantena SR, Kannan A, Evans DB, Bagchi MK, Bagchi IC. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12542-7. Epub 2009 Jul 20. Erratum in: Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):16003. PMID: 19620711 | PNAS
- Implantation is initiated when the embryo attaches to the uterine luminal epithelium during early pregnancy.
- Following this event, uterine stromal cells undergo steroid hormone-dependent transformation into morphologically and functionally distinct decidual cells in a unique process known as decidualization.
- An angiogenic network is also formed in the uterine stromal bed, critically supporting the early development of the embryo.
- ovarian progesterone as a key regulator of decidualization is well established
- these studies in mice - identified the decidual uterus as a novel site of estrogen biosynthesis and uncovered estrogen-regulated maternal signaling pathways that critically control uterine differentiation and angiogenesis during early pregnancy.