Talk:Neural - Telencephalon Development

2011

Characterization of the proteome, diseases and evolution of the human postsynaptic density

Àlex Bayés, Louie N van de Lagemaat, Mark O Collins, Mike D R Croning, Ian R Whittle, Jyoti S Choudhary and Seth G N Grant doi:10.1038/nn.2719 This study identifies proteins from the postsynaptic density (PSD) of human neocortex and finds that the PSD shows enrichment of genes involved in cognitive and affective phenotypes and that PSD mutations are associated with neurological and psychiatric disease.

We isolated the postsynaptic density from human neocortex (hPSD) and identified 1,461 proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were enriched in cognitive, affective and motor phenotypes underpinned by sets of genes.

Nature Neuroscience 14, 19–21 (2011) doi:10.1038/nn.2719 Received 23 June 2010 Accepted 12 November 2010 Published online 19 December 2010

http://www.nature.com/neuro/journal/v14/n1/abs/nn.2719.html?lang=en