Talk:Mouse Lung Movie 1

Tracking X-ray microscopy for alveolar dynamics in live intact mice

Sci Rep. 2013 Feb 18;3:1304. doi: 10.1038/srep01304.

Chang S, Kwon N, Weon BM, Kim J, Rhee CK, Choi HS, Kohmura Y, Yamamoto M, Ishikawa T, Je JH. Source 1] X-ray Imaging Center, Pohang University of Science and Technology, San 31, Hyoja-dong, Pohang, 790-784, Korea [2] Department of Materials Science and Engineering, Pohang University of Science and Technology, San 31, Hyoja-dong, Pohang, 790-784, Korea. Abstract Here we report a tracking X-ray microscopy (TrXM) as a novel methodology by using upper right lung apices alveoli in live intact mice. By enabling tracking of individual alveolar movements during respiration, TrXM identifies alveolar dynamics: individual alveoli in the upper lung apices show a small size increment as 4.9 ± 0.4% (mean ± s.e.m.) during respiration while their shapes look almost invariant. TrXM analysis in alveolar dynamics would be significant for better understanding of alveolar-based diseases, for instance, ventilator induced lung injury (VILI) in acute respiratory distress syndrome (ARDS).

PMID 23416838

http://www.nature.com/srep/2013/130218/srep01304/full/srep01304.html