Talk:Madrid Collection
Embryonic cardiac morphometry in Carnegie stages 15-23, from the Complutense University of Madrid Institute of Embryology Human Embryo Collection
Cells Tissues Organs. 2008;187(3):211-20. Epub 2007 Dec 5.
Arráez-Aybar LA1, Turrero-Nogués A, Marantos-Gamarra DG.
Abstract
AIMS: We performed a morphometric study of cardiac development on human embryos to complement the scarce data on human embryonic cardiac morphometry and to attempt to establish, from these, algorithms describing cardiac growth during the second month of gestation. METHODS: Thirty human embryos from Carnegie stages 15-23 were included in the study. Shrinkage and compression effects from fixation and inclusion in paraffin were considered in our calculations. RESULTS: Growth of the cardiac (whole heart) volume and volume of ventricular myocardium through the Carnegie stages were analysed by ANOVA. Linear correlation was used to describe the relationship between the ventricular myocardium and cardiac volumes. Comparisons of models were carried out through the R2 statistic. The relationship volume of ventricular myocardium versus cardiac volume is expressed by the equation: cardiac volume = 0.6266 + 2.4778 volume of ventricular myocardium. The relationship cardiac volume versus crown-rump length is expressed by the equation: cardiac volume = 1.3 e(0.126 CR length), where e is the base of natural logarithms. CONCLUSION: At a clinical level, these results can contribute towards the establishment of a normogram for cardiac development, useful for the design of strategies for early diagnosis of congenital heart disease. They can also help in the study of embryogenesis, for example in the discussion of ventricular trabeculation. Copyright 2007 S. Karger AG, Basel.
PMID 18057862
<pubmed>18057862</pubmed>| Cells Tissues Organs
Image source
The collection was started in 1935 by Professor Orts-Llorca (1905-1993) after its embryological formation in Paris with Henri Rouviere (1875-1952), in Brussels with Albert Dalcq (1893-1973), in Vienna with Alfred Fischel (1868-1938) and Munich with Walter Vogt (1888-1941) and Johannes Holtfreter (1901 - 1992). In Valencia live the Spanish Civil War (1936-39). In Cádiz (1939-1953) overcomes the difficulties associated with it, which did not prevent him form his collection of human embryos. In 1954 he was named full professor at the Central University of Madrid (Complutense current) enriching its collection (Orts-Llorca, 1984). In 1977 he was succeeded by Professor Juan Jiménez-Collado (1932) who incorporates his own collection and manages the creation of the Complutense Institute of Embryology. This is created in 1980, incorporating both seasons. Professor Jiménez-Collado is named Head of it. In 2002 Professor José-Vicente Sanz-Casado (1957) happens and your current Head.
Orts-Llorca F. 1984. Embriones y fetos humanos de diversas universidades españolas. Madrid: Editorial Universidad Complutense
A glance at Spanish embryology and teratology during the XX century through the academic life of Francisco Orts-Llorca (1905-1993)
Int J Dev Biol. 2009;53(8-10):1165-77. doi: 10.1387/ijdb.072492ja.
Aréchaga J1, Jiménez-Collado J, Ruano-Gil D. Author information
Abstract Francisco Ort-Llorca (1905-1993) was one of the most outstanding Spanish embryologists of the XX century. He was disciple of Henri Rouvire in Paris (France), Alfred Fischel in Vienna (Austria), Walther Vogt in Munich (Germany) and Pedro Ara in Madrid (Spain). From 1935, he was professor of Human Anatomy at the Faculty of Medicine of Cadiz, belonged then to the University of Seville (accidentally, in the University of Valencia, during the Spanish Civil War from 1936-1939) and, later on, at the Faculty of Medicine of Madrid (Complutense University) from 1954 to 1975. He was internationally recognized in anatomical sciences and stood out for his contributions to descriptive and experimental Embryology and Teratology, particularly in those aspects connected to the normal and pathological development of the heart and visual organs. PMID 19924623
<pubmed>19924623</pubmed>
PMID 4428951
Orts-Llorca F (1984) Embriones y fetos humanos de diversas Universidades españolas. Editorial Universidad Complutense.
Contact
Prof Luis Arráez Aybar
Prof Sanz-Casado
Departamento de Anatomía y Anatomía Patológica Comparada (Anatomía y Embriología)
http://www.ucm.es/dep-anatomiayembriologia
Department of Anatomy and Comparative Pathology (Anatomy and Embryology)
Universidad Complutense de Madrid
Morphogenesis of the manubrium of sternum in human embryos: a new concept
Anat Rec (Hoboken). 2013 Feb;296(2):279-89. doi: 10.1002/ar.22623. Epub 2012 Nov 19.
Rodríguez-Vázquez JF1, Verdugo-López S, Garrido JM, Murakami G, Kim JH.
Abstract
To revisit many theories on fetal development of the manubrium of the sternum, we examined 25 mid-term fetuses at 6-9 weeks of gestation. The initial developmental stage of the manubrium was characterized by a distinct interclavicular mesenchyme that was continuous with the developing clavicles. Because parts of the clavicle in which endochondral ossification occurs originate from the neural crest, the interclavicular mesenchyme seems to be of the same origin. The sternal bands, possibly of the lateral plate origin, were restricted at the anterior ends of the ribs in the paired thoracic walls. The interclavicular mesenchyme extended caudally and laterally to reach the anterior ends of the first ribs, and thus the interclavicular mesenchyme expanded into the intercostoclavicular mesenchyme. Then, the primitive manubrium was delimited by the sternoclavicular joint and its related ligaments, all of which developed from the interclavicular and intercostoclavicular mesenchymes. Although the first ribs were attached to the intercostoclavicular mesenchyme, the former was vimentin-negative in contrast to the latter, positive mesenchyme. Soon afterwards, the small upper end of the sternal bands was integrated into the intercostoclavicular mesenchyme to form the primitive manubrium. The infrahyoid muscles and their supplying nerves maintained a close topographical relation to the interclavicular or intercostoclavicular mesenchyme, whereas the pectoralis major muscle kept attachments to the sternal bands. Consequently, the manubrium of sternum appeared to develop in a complex way at a junction area between derivatives of the neural crest, lateral plate, and somite. Copyright © 2012 Wiley Periodicals, Inc.
PMID 23165944
