Talk:Integumentary System - Tooth Development: Difference between revisions
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Text: Mitsiadis etal Developmental Biology,v 204, n 2, December 15, 1998, p420-431 | Text: Mitsiadis etal Developmental Biology,v 204, n 2, December 15, 1998, p420-431 | ||
<pubmed>17394220</pubmed> | |||
<pubmed>16632755</pubmed> | |||
<pubmed>16651263</pubmed> | |||
<pubmed>9520113</pubmed> | |||
===Search PubMed=== | |||
Search Mar 2007 "tooth development" '''4,318''' reference articles of which '''422''' were reviews. | Search Mar 2007 "tooth development" '''4,318''' reference articles of which '''422''' were reviews. | ||
'''Search PubMed:''' term = [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=tooth%20development tooth development] | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=odontogenesis odontogenesis] | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=tooth%20morphogenesis tooth morphogenesis] | | '''Search PubMed:''' term = [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=tooth%20development tooth development] | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=odontogenesis odontogenesis] | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=tooth%20morphogenesis tooth morphogenesis] | | ||
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=adontia adontia] | | |||
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=amelogenesis%20imperfecta amelogenesis imperfecta] | | |||
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=dens%20evaginatus dens evaginatus] | | |||
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=hypodontia hypodontia] | | |||
== Terms == | == Terms == | ||
'''Dental Terms:''' ameloblast, amelogenin, amine fluoride (AmF), acidulated phosphate fluoride (APF), biomineralization, calcium phosphate (CaP), cementogenesis, dentoenamel junction (DEJ) decayed and filled primary teeth, decayed and filled surfaces on primary teeth, decayed, missing, and filled permanent teeth (DMF), decayed, missing, and filled surfaces on permanent teeth (DMFS), dentin sialophosphoprotein, enamel hypoplasia, ferric aluminum fluoride (FeAlF), periodontal ligament, sodium fluoride (NaF), stannous fluoride (SnF), titanium tetrafluoride (TiF). | '''Dental Terms:''' ameloblast, amelogenin, amine fluoride (AmF), acidulated phosphate fluoride (APF), biomineralization, calcium phosphate (CaP), cementogenesis, dentoenamel junction (DEJ) decayed and filled primary teeth, decayed and filled surfaces on primary teeth, decayed, missing, and filled permanent teeth (DMF), decayed, missing, and filled surfaces on permanent teeth (DMFS), dentin sialophosphoprotein, enamel hypoplasia, ferric aluminum fluoride (FeAlF), periodontal ligament, sodium fluoride (NaF), stannous fluoride (SnF), titanium tetrafluoride (TiF). |
Revision as of 09:47, 26 October 2010
http://embryology.med.unsw.edu.au/Notes/skin10.htm
http://www.ncbi.nlm.nih.gov/pubmed/19750524
Cell fate determination during tooth development and regeneration.
- "Teeth arise from sequential and reciprocal interactions between the oral epithelium and the underlying cranial neural crest-derived mesenchyme. Their formation involves a precisely orchestrated series of molecular and morphogenetic events, and gives us the opportunity to discover and understand the nature of the signals that direct cell fates and patterning. For that reason, it is important to elucidate how signaling factors work together in a defined number of cells to generate the diverse and precise patterned structures of the mature functional teeth. Over the last decade, substantial research efforts have been directed toward elucidating the molecular mechanisms that control cell fate decisions during tooth development. These efforts have contributed toward the increased knowledge on dental stem cells, and observation of the molecular similarities that exist between tooth development and regeneration."
Tooth Cells
Ameloblasts - Pre-ameloblasts differentiate from the inner enamel epithelium. Cells secrete enamel
Cementoblasts
Odontoblasts - neural crest-derived mesenchymal cells which differentiate under the influence of the enamel epithelium. Cells secrete dentin.
Epithelial Mesenchymal Interaction
- local ectodermal thickening expresses several signaling molecules
- these in turn signal to the underlying mesenchyme triggering mesenchymal condensation
(epithelially expressed Bmp4 induces Msx1 and Lef1 as well as itself in the underlying mesenchyme)
Four epithelial signaling molecules, Bmp2, Shh, Wnt10a, and Wnt10b, in the early inductive cascade, each signal has a distinct molecular action on the jaw mesenchyme.
Mouse (E11.0 and E12.0) - all four genes are specifically expressed in the epithelium.
Shh and Wnt10b induce general Hedgehog and Wnt targets, Ptc and Gli for Shh and Lef1 for Wnt10b,
Bmp2 is able to induce tooth-specific expression of Msx1.
(Text above modified from: Hélène R. Dassule and Andrew P. McMahon Developmental Biology, v 202, n 2, October 15, 1998, p215-227)
(More? [mechanism1.htm Developmental Mechanism - Epithelial Mesenchymal Interaction])
Periodontal Ligament (PDL)
The tooth is not anchored directly onto its bony socket (alveolar bone) but held in place by the periodontal ligament (PDL), a specialized connective tissue structure that surrounds the tooth root coating of cementum.
The additional roles of the PDL are to also act as; a shock absorber, transmitter of chewing forces (from tooth to bone), sensory information (heat, cold, pressure and pain).
The collagen fiber bundles within the ligament are called "Sharpey’s fibres".
Cementum (from investing layer of the dental follicle) is contiguous layer with the periodontal ligament on one surface and firmly adherent to dentine on the other surface.
(More? [skmus.htm Musculoskeletal Development])
Molecular Tooth Development
More than 300 genes have been associated with tooth development including: BMP4, FGF8, MSX1, MSX2, PAX9, PITX2, SHOX2, Delta/Notch, Hox-8, Runx2
Most recent review in Developmental Dynamics by Lin D, Huang Y, He F, Gu S, Zhang G, Chen Y, Zhang Y. Expression survey of genes critical for tooth development in the human embryonic tooth germ. Dev Dyn. 2007 Mar 29.
Amelogenin - abundant protein secreted by ameloblasts which is a major component of tooth enamel.
The papers below are from UNSW Embryology (version 3), information requires updating.
Bone Morphogenic Protein (BMP) / Fibroblast Growth Factor (FGF)
Growth factors in the BMP- and FGF-families are expressed in dental epithelium during initiation of tooth development and their effects on the underlying mesenchyme mimic those of the epithelium. They upregulate the expression of many genes, including the homeobox-containing Msx-1 and Msx-2, and stimulate cell proliferation suggesting that they may act as epithelial signals transmitting epithelial-mesenchymal interactions. During subsequent morphogenesis, when the characteristic shapes of individual teeth develop as a result from folding of the dental epithelium, several signal molecules including Sonic hedgehog, Bmps-2, 4, 7 and Fgf-4 are expressed specifically in restricted and transient epithelial cell clusters, called enamel knots.
(Text: Irma Thesleff and Carin Sahlberg Seminars in Cell & Developmental Biology, v 7, n 2, April, 1996, p185-193)
Delta/Notch
The expression pattern of Delta 1 in ameloblasts and odontoblasts is complementary to Notch1, Notch2, and Notch3 expression in adjacent epithelial and mesenchymal cells. Notch1 and Notch2 are upregulated in explants of dental mesenchyme adjacent to implanted cells expressing Delta1, suggesting that feedback regulation by Delta-Notch signaling ensures the spatial segregation of Notch receptors and ligands. TGF1 and BMPs induce Delta1 expression in dental mesenchyme explants at the stage at which Delta1 is upregulated in vivo, but not at earlier stages. In contrast to the Notch family receptors and their ligand Jagged1, expression of Delta1 in the tooth germ is not affected by epithelial-mesenchymal interactions, showing that the Notch receptors and their two ligands Jagged1 and Delta1 are subject to different regulations.
Text: Mitsiadis etal Developmental Biology,v 204, n 2, December 15, 1998, p420-431
<pubmed>17394220</pubmed> <pubmed>16632755</pubmed> <pubmed>16651263</pubmed> <pubmed>9520113</pubmed>
Search PubMed
Search Mar 2007 "tooth development" 4,318 reference articles of which 422 were reviews.
Search PubMed: term = tooth development | odontogenesis | tooth morphogenesis | adontia | amelogenesis imperfecta | dens evaginatus | hypodontia |
Terms
Dental Terms: ameloblast, amelogenin, amine fluoride (AmF), acidulated phosphate fluoride (APF), biomineralization, calcium phosphate (CaP), cementogenesis, dentoenamel junction (DEJ) decayed and filled primary teeth, decayed and filled surfaces on primary teeth, decayed, missing, and filled permanent teeth (DMF), decayed, missing, and filled surfaces on permanent teeth (DMFS), dentin sialophosphoprotein, enamel hypoplasia, ferric aluminum fluoride (FeAlF), periodontal ligament, sodium fluoride (NaF), stannous fluoride (SnF), titanium tetrafluoride (TiF).