Talk:Integumentary System - Hair Development

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On this website the Discussion Tab or "talk pages" for a topic has been used for several purposes: References - recent and historic that relates to the topic Additional topic information - currently prepared in draft format Links - to related webpages Topic page - an edit history as used on other Wiki sites Lecture/Practical - student feedback Student Projects - online project discussions. Links: Pubmed Most Recent | Reference Tutorial | Journal Searches Glossary Links Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link Cite this page: Hill, M.A. (2024, April 23) Embryology Integumentary System - Hair Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Integumentary_System_-_Hair_Development

2011

Notch signaling regulates late-stage epidermal differentiation and maintains postnatal hair cycle homeostasis

PLoS One. 2011 Jan 18;6(1):e15842.

Lin HY, Kao CH, Lin KM, Kaartinen V, Yang LT. Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli County, Taiwan, Republic of China.

Abstract

BACKGROUND: Notch signaling involves ligand-receptor interactions through direct cell-cell contact. Multiple Notch receptors and ligands are expressed in the epidermis and hair follicles during embryonic development and the adult stage. Although Notch signaling plays an important role in regulating differentiation of the epidermis and hair follicles, it remains unclear how Notch signaling participates in late-stage epidermal differentiation and postnatal hair cycle homeostasis.

METHODOLOGY AND PRINCIPAL FINDINGS: We applied Cre/loxP system to generate conditional gene targeted mice that allow inactivation of critical components of Notch signaling pathway in the skin. Rbpj, the core component of all four Notch receptors, and Pofut1, an essential factor for ligand-receptor interactions, were inactivated in hair follicle lineages and suprabasal layer of the epidermis using the Tgfb3-Cre mouse line. Rbpj conditional inactivation resulted in granular parakeratosis and reactive epidermal hyperplasia. Pofut1 conditional inactivation led to ultrastructural abnormalities in the granular layer and altered filaggrin processing in the epidermis, suggesting a perturbation of the granular layer differentiation. Disruption of Pofut1 in hair follicle lineages resulted in aberrant telogen morphology, a decrease of bulge stem cell markers, and a concomitant increase of K14-positive keratinocytes in the isthmus of mutant hair follicles. Pofut1-deficent hair follicles displayed a delay in anagen re-entry and dysregulation of proliferation and apoptosis during the hair cycle transition. Moreover, increased DNA double stand breaks were detected in Pofut1-deficent hair follicles, and real time PCR analyses on bulge keratinocytes isolated by FACS revealed an induction of DNA damage response and a paucity of DNA repair machinery in mutant bulge keratinocytes.

SIGNIFICANCE: our data reveal a role for Notch signaling in regulating late-stage epidermal differentiation. Notch signaling is required for postnatal hair cycle homeostasis by maintaining proper proliferation and differentiation of hair follicle stem cells.

PMID: 21267458 http://www.ncbi.nlm.nih.gov/pubmed/21267458

2010

Cyclic expression of lhx2 regulates hair formation

Törnqvist G, Sandberg A, Hägglund AC, Carlsson L. PLoS Genet. 2010 Apr 8;6(4):e1000904. PMID: 20386748 http://www.ncbi.nlm.nih.gov/pubmed/20386748

Hair is important for thermoregulation, physical protection, sensory activity, seasonal camouflage, and social interactions. Hair is generated in hair follicles (HFs) and, following morphogenesis, HFs undergo cyclic phases of active growth (anagen), regression (catagen), and inactivity (telogen) throughout life. The transcriptional regulation of this process is not well understood. We show that the transcription factor Lhx2 is expressed in cells of the outer root sheath and a subpopulation of matrix cells during both morphogenesis and anagen. As the HFs enter telogen, expression becomes undetectable and reappears prior to initiation of anagen in the secondary hair germ. In contrast to previously published results, we find that Lhx2 is primarily expressed by precursor cells outside of the bulge region where the HF stem cells are located. This developmental, stage- and cell-specific expression suggests that Lhx2 regulates the generation and regeneration of hair. In support of this hypothesis, we show that Lhx2 is required for anagen progression and HF morphogenesis. Moreover, transgenic expression of Lhx2 in postnatal HFs is sufficient to induce anagen. Thus, our results reveal an alternative interpretation of Lhx2 function in HFs compared to previously published results, since Lhx2 is periodically expressed, primarily in precursor cells distinct from those in the bulge region, and is an essential positive regulator of hair formation.

http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000904

Characterization of the correlation between ages at entry into breast and pubic hair development

Ann Epidemiol. 2010 May;20(5):405-8.

Christensen KY, Maisonet M, Rubin C, Flanders WD, Drews-Botsch C, Dominguez C, McGeehin MA, Marcus M.

Epidemiology Department, Emory University, Atlanta, GA 30322, USA. klyorita@gmail.com Abstract PURPOSE: The timing of breast and pubic hair development in girls are related, but the degree of correlation has not been well characterized. Periodic observations also are complicated by interval censoring.

METHODS: Data used were from the Avon Longitudinal Study of Parents and Children. Mean age at entry into breast and pubic hair development was determined by the use of parametric survival analysis. The bivariate normal cumulative distribution function was evaluated over the region containing the paired event times; the likelihood was maximized with respect to the correlation coefficient rho.

RESULTS: Among 3938 participants, estimated mean ages at entry into Tanner stage 2 for breast and pubic hair development were 10.19 and 10.95, respectively. The likelihood was maximized at rho = 0.503 to 0.506. This value remained relatively constant among subgroups, although some heterogeneity was observed by maternal and child body mass index and birth order.

CONCLUSIONS: The timing of breast and of pubic hair development is moderately correlated and remain so when it is stratified by characteristics associated with puberty.

PMID: 20382343

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877869

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(see also Genital System Development)

Original Page References

Reviews

Peters EM, Arck PC, Paus R. Hair growth inhibition by psychoemotional stress: a mouse model for neural mechanisms in hair growth control. Exp Dermatol. 2006 Jan;15(1):1-13.

Sundberg JP, Peters EM, Paus R. Analysis of hair follicles in mutant laboratory mice. J Investig Dermatol Symp Proc. 2005 Dec;10(3):264-70.

Botchkarev VA, Fessing MY. Edar signaling in the control of hair follicle development. J Investig Dermatol Symp Proc. 2005 Dec;10(3):247-51.

Stenn KS, Cotsarelis G. Bioengineering the hair follicle: fringe benefits of stem cell technology. Curr Opin Biotechnol. 2005 Oct;16(5):493-7.

Schmidt-Ullrich R, Paus R. Molecular principles of hair follicle induction and morphogenesis. Bioessays. 2005 Mar;27(3):247-61.

Ahmad W, Panteleyev AA, Christiano AM. The molecular basis of congenital atrichia in humans and mice: mutations in the hairless gene. J Investig Dermatol Symp Proc. 1999 Dec;4(3):240-3.

Ebling FJ. Hair follicles and associated glands as androgen targets. Clin Endocrinol Metab. 1986 May;15(2):319-39.

Articles

Wang Y, Badea T, Nathans J. Order from disorder: Self-organization in mammalian hair patterning. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19800-5. Epub 2006 Dec 15. PNAS Link

Ouji Y, Yoshikawa M, Shiroi A, Ishizaka S. Promotion of hair follicle development and trichogenesis by Wnt-10b in cultured embryonic skin and in reconstituted skin. Biochem Biophys Res Commun. 2006 Jun 30;345(2):581-7.

Cui CY, Hashimoto T, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D. Ectodysplasin regulates the lymphotoxin-{beta} pathway for hair differentiation. Proc Natl Acad Sci U S A. 2006 May 31

Search NCBI Bookshelf: Bookshelf - hair development

Developmental Biology - Development of the hair follicles in fetal human skin | Eurekah Bioscience Collection - Role of GLI proteins in embryonic hair follicle development | Molecular Biology of the Cell - FGF5 is a negative regulator of hair formatio

Search PubMed: Search May 2006 "hair development" 6,574 reference articles of which 813 were reviews.

Search term = hair development | hair follicle development | lanugo hair