Talk:Genital System Development

Background Reading

MicroRNA in the ovary and female reproductive tract. Carletti MZ, Christenson LK. J Anim Sci. 2009 Apr;87(14 Suppl):E29-38. Epub 2008 Sep 12. Review. PMID: 18791135

"Interestingly, when Dicer1 expression is decreased in reproductive tissues or cells, the females are infertile."

Meeting report: measuring endocrine-sensitive endpoints within the first years of life. Arbuckle TE, Hauser R, Swan SH, Mao CS, Longnecker MP, Main KM, Whyatt RM, Mendola P, Legrand M, Rovet J, Till C, Wade M, Jarrell J, Matthews S, Van Vliet G, Bornehag CG, Mieusset R. Environ Health Perspect. 2008 Jul;116(7):948-51. PMID: 18629319 | PMC: 2453165] | Supplementary PDF

"An international workshop titled "Assessing Endocrine-Related Endpoints within the First Years of Life" was held 30 April-1 May 2007, in Ottawa, Ontario, Canada. Representatives from a number of pregnancy cohort studies in North America and Europe presented options for measuring various endocrine-sensitive endpoints in early life and discussed issues related to performing and using those measures. The workshop focused on measuring reproductive tract developmental endpoints [e.g., anogenital distance (AGD)], endocrine status, and infant anthropometry. To the extent possible, workshop participants strove to develop or recommend standardized measurements that would allow comparisons and pooling of data across studies. The recommended outcomes include thigh fat fold, breast size, vaginal cytology, AGD, location of the testis, testicular size, and growth of the penis, with most of the discussion focusing on the genital exam. Although a number of outcome measures recommended during the genital exam have been associated with exposure to endocrine-disrupting chemicals, little is known about how predictive these effects are of later reproductive health or other chronic health conditions."