Talk:Genetic risk maternal age

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On this website the Discussion Tab or "talk pages" for a topic has been used for several purposes: References - recent and historic that relates to the topic Additional topic information - currently prepared in draft format Links - to related webpages Topic page - an edit history as used on other Wiki sites Lecture/Practical - student feedback Student Projects - online project discussions. Links: Pubmed Most Recent | Reference Tutorial | Journal Searches Glossary Links Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link Cite this page: Hill, M.A. (2024, April 16) Embryology Genetic risk maternal age. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Genetic_risk_maternal_age

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Note - This sub-heading shows an automated computer PubMed search using the listed sub-heading term. References appear in this list based upon the date of the actual page viewing. Therefore the list of references do not reflect any editorial selection of material based on content or relevance. In comparison, references listed on the content page and discussion page (under the publication year sub-headings) do include editorial selection based upon relevance and availability. (More? Pubmed Most Recent)

Genetic risk maternal age

<pubmed limit=5>Genetic risk maternal age</pubmed>

2005

Frequency and distribution of chromosome abnormalities in human oocytes

Kuliev A, Cieslak J, Verlinsky Y. Cytogenet Genome Res. 2005;111(3-4):193-8.

PMID 16192694

"It was previously shown that more than half of the human oocytes obtained from IVF patients of advanced reproductive age are aneuploid, due to meiosis I and meiosis II errors. The present paper further confirms that 61.8% of the oocytes tested by fluorescent probes specific for chromosomes 13, 16, 18, 21 and 22 are abnormal, representing predominantly chromatid errors, which are the major source of aneuploidy in the resulting embryos. Almost half of the oocytes with meiosis I errors (49.3%) are prone to sequential meiosis II errors, which may lead to aneuploidy rescue in 30.8% of the cases."

• Differences in chromosome susceptibility to aneuploidy and survival to first trimester. http://www.ncbi.nlm.nih.gov/pubmed/14759293

"The purpose of this study was to find specific rates of aneuploidy in cleavage-stage embryos compared with first trimester data and to evaluate post-zygotic selection against aneuploidy. A total of 2058 embryos were analysed by flurorescence in-situ hybridization (FISH), and specific aneuploidy rates were obtained for 14 chromosomes. Data from morphologically abnormal embryos could be pooled with data from preimplantation genetic diagnosis (PGD) cycles because it was observed that they had similar rates of aneuploidy; thus, for the purpose of studying aneuploidy they could be, and were, pooled. Specific chromosome aneuploidy rates were not related to morphology or development of the embryos. The average maternal age of patients with aneuploid embryos was significantly higher than the overall analysed population. Monosomy appeared more commonly than trisomy. The chromosomes most frequently involved in aneuploidy were (in order) 22, 16, 21 and 15. When compared with first trimester pregnancy data, aneuploidies detected at cleavage stage seem to die in excess of 90% before reaching first trimester, with the exception of chromosome 16 and gonosomes (76% and 14% respectively). Differences in chromosome-specific aneuploidy rates at first trimester conceptions are probably produced by different chromosome-specific aneuploidy rates at cleavage stage and different survival rates to first trimester."

• http://www.ncbi.nlm.nih.gov/pubmed/16437524

• Trisomy recurrence: a reconsideration based on North American data. http://www.ncbi.nlm.nih.gov/pubmed/15248154

• Comparison of current methods of prenatal screening for down syndrome - Article in Spanish http://www.ncbi.nlm.nih.gov/pubmed/20376412

1985

Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy

Hassold T, Chiu D. Hum Genet. 1985;70(1):11-7.

PMID 3997148

Consider using this as a Collapsible table on the trisomy 21 page.

http://www.mediawiki.org/wiki/Manual:Collapsible_tables

Simple collapsible table
Lorem ipsum dolor sit amet

Need to Copy and paste the following text into your wiki's MediaWiki:Common.js and MediaWiki:Common.css:

Common.js

/** Collapsible tables *********************************************************

*
*  Description: Allows tables to be collapsed, showing only the header. See
*               **DOCUMENTATION LINK**.
*  Maintainers: **MAINTAINERS**
*/

var autoCollapse = 2; var collapseCaption = "hide"; var expandCaption = "show";

function collapseTable( tableIndex ) {

   var Button = document.getElementById( "collapseButton" + tableIndex );
   var Table = document.getElementById( "collapsibleTable" + tableIndex );

   if ( !Table || !Button ) {
       return false;
   }

   var Rows = Table.rows;

   if ( Button.firstChild.data == collapseCaption ) {
       for ( var i = 1; i < Rows.length; i++ ) {
           Rows[i].style.display = "none";
       }
       Button.firstChild.data = expandCaption;
   } else {
       for ( var i = 1; i < Rows.length; i++ ) {
           Rows[i].style.display = Rows[0].style.display;
       }
       Button.firstChild.data = collapseCaption;
   }

}

function createCollapseButtons() {

   var tableIndex = 0;
   var NavigationBoxes = new Object();
   var Tables = document.getElementsByTagName( "table" );

   for ( var i = 0; i < Tables.length; i++ ) {
       if ( hasClass( Tables[i], "collapsible" ) ) {

           /* only add button and increment count if there is a header row to work with */
           var HeaderRow = Tables[i].getElementsByTagName( "tr" )[0];
           if (!HeaderRow) continue;
           var Header = HeaderRow.getElementsByTagName( "th" )[0];
           if (!Header) continue;

           NavigationBoxes[ tableIndex ] = Tables[i];
           Tables[i].setAttribute( "id", "collapsibleTable" + tableIndex );

           var Button     = document.createElement( "span" );
           var ButtonLink = document.createElement( "a" );
           var ButtonText = document.createTextNode( collapseCaption );

           Button.className = "collapseButton";  //Styles are declared in Common.css

           ButtonLink.style.color = Header.style.color;
           ButtonLink.setAttribute( "id", "collapseButton" + tableIndex );
           ButtonLink.setAttribute( "href", "javascript:collapseTable(" + tableIndex + ");" );
           ButtonLink.appendChild( ButtonText );

           Button.appendChild( document.createTextNode( "[" ) );
           Button.appendChild( ButtonLink );
           Button.appendChild( document.createTextNode( "]" ) );

           Header.insertBefore( Button, Header.childNodes[0] );
           tableIndex++;
       }
   }

   for ( var i = 0;  i < tableIndex; i++ ) {
       if ( hasClass( NavigationBoxes[i], "collapsed" ) || ( tableIndex >= autoCollapse && hasClass( NavigationBoxes[i], "autocollapse" ) ) ) {
           collapseTable( i );
       } 
   }

}

addOnloadHook( createCollapseButtons );

/** Test if an element has a certain class **************************************

 *
 * Description: Uses regular expressions and caching for better performance.
 * Maintainers: User:Mike Dillon, User:R. Koot, User:SG
 */

var hasClass = (function () { var reCache = {}; return function (element, className) { return (reCache[className] ? reCache[className] : (reCache[className] = new RegExp("(?:\\s|^)" + className + "(?:\\s|$)"))).test(element.className); }; })();

Common.css

.collapseButton { /* 'show'/'hide' buttons created dynamically by the */

   float: right;         /* CollapsibleTables javascript in MediaWiki:Common.js */
   font-weight: normal;  /* are styled here so they can be customised.              */
   text-align: right;
   width: auto;

} [edit]Markup

The following markup in pages now makes collapsible sections:

This is the header cell, which is always shown
This cell is not shown by default.