Talk:Endocrine - Pineal Development: Difference between revisions
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==2011== | ==2011== | ||
===Melatonin as a central molecule connecting neural development and calcium signaling=== | |||
Funct Integr Genomics. 2011 Apr 5. [Epub ahead of print] | |||
de Faria Poloni J, Feltes BC, Bonatto D. | |||
Source | |||
Instituto de Biotecnologia, Universidade de Caxias do Sul (UCS), Caxias do Sul, Rio Grande do Sul, Brazil. | |||
Abstract | |||
Melatonin (MEL) is a neuroendocrine hormone secreted by the pineal gland in association with the suprachiasmatic nucleus and peripheral tissues. MEL has been observed to play a critical role in the reproductive process and in the fetomaternal interface. Extrapineal synthesis has been reported in mammalian models during pregnancy, especially by the placenta tissue. MEL can regulate intracellular processes (e.g., G-proteins) and the activity of second messengers (e.g., cAMP, IP(3,) Ca(2+)). During neurodevelopment, these activities regulated by melatonin have an important role as an intracellular signaling for gene expression regulation. To review the role of MEL in neurodevelopment, we built interactome networks of different proteins that act in these processes using systems biology tools. The analyses of interactome networks revealed that MEL could modulate neurodevelopment through the regulation of Ca(2+) intracellular levels and influencing BMP/SMAD signaling, thus affecting neural gene responses and neuronal differentiation. | |||
PMID: 21465271 | |||
http://www.ncbi.nlm.nih.gov/pubmed/21465271 | |||
Revision as of 22:50, 25 May 2011
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Cite this page: Hill, M.A. (2024, April 18) Embryology Endocrine - Pineal Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Endocrine_-_Pineal_Development |
2011
Melatonin as a central molecule connecting neural development and calcium signaling
Funct Integr Genomics. 2011 Apr 5. [Epub ahead of print]
de Faria Poloni J, Feltes BC, Bonatto D. Source Instituto de Biotecnologia, Universidade de Caxias do Sul (UCS), Caxias do Sul, Rio Grande do Sul, Brazil.
Abstract
Melatonin (MEL) is a neuroendocrine hormone secreted by the pineal gland in association with the suprachiasmatic nucleus and peripheral tissues. MEL has been observed to play a critical role in the reproductive process and in the fetomaternal interface. Extrapineal synthesis has been reported in mammalian models during pregnancy, especially by the placenta tissue. MEL can regulate intracellular processes (e.g., G-proteins) and the activity of second messengers (e.g., cAMP, IP(3,) Ca(2+)). During neurodevelopment, these activities regulated by melatonin have an important role as an intracellular signaling for gene expression regulation. To review the role of MEL in neurodevelopment, we built interactome networks of different proteins that act in these processes using systems biology tools. The analyses of interactome networks revealed that MEL could modulate neurodevelopment through the regulation of Ca(2+) intracellular levels and influencing BMP/SMAD signaling, thus affecting neural gene responses and neuronal differentiation.
PMID: 21465271 http://www.ncbi.nlm.nih.gov/pubmed/21465271
