Talk:Developmental Signals - Sonic hedgehog

From Embryology
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Some Recent Findings

  • Dynamic interpretation of hedgehog signaling in the Drosophila wing disc. [1]
  • Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb.[2]
  • Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.[3] "One of the first changes we noted was that the dorsoventral polarity of the forebrain was disturbed, which manifested as a loss of Shh in the ventral telencephalon, a reduction in expression of the ventral markers Nkx2.1 and Dlx2, and a concomitant expansion of the dorsal marker Pax6. In addition to changes in the forebrain neuroectoderm, we observed altered gene expression patterns in the facial ectoderm. For example, Shh was not induced in the frontonasal ectoderm, and Ptc and Gli1 were reduced in both the ectoderm and adjacent mesenchyme."
  • THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.[4]
  • Triphalangeal thumb-polysyndactyly syndrome and syndactyly type IV are caused by genomic duplications involving the long-range, limb-specific SHH enhancer.[5]
  • Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. [6]


Some Recent Findings

  • Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. Butterfield NC, Metzis V, McGlinn E, Bruce SJ, Wainwright BJ, Wicking C. Development. 2009 Oct;136(20):3515-24. PMID: 19783740
  • Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome. Anderson C, Thorsteinsdóttir S, Borycki AG. Development. 2009 Oct;136(20):3495-504. PMID: 19783738
  • Molecular and tissue interactions governing induction of cranial ectodermal placodes. McCabe KL, Bronner-Fraser M. Dev Biol. 2009 Aug 15;332(2):189-95. Epub 2009 Jun 2. Review. PMID: 19500565
  1. <pubmed>19787036</pubmed> | PLOS
  2. <pubmed>19783740</pubmed>
  3. <pubmed>18410737</pubmed>
  4. <pubmed>18327258</pubmed>
  5. <pubmed>18417549</pubmed>
  6. <pubmed>18272593</pubmed>