Difference between revisions of "Talk:Developmental Signals - Homeobox"

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<i>Hox protein</i>
<i>Hox protein</i>
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Revision as of 07:23, 29 November 2011

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Cite this page: Hill, M.A. (2020, February 17) Embryology Developmental Signals - Homeobox. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Developmental_Signals_-_Homeobox

Search All Databases hox

UNSW Embryology - Molecular Notes | Musculoskeletal Notes

PMID 20485555 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010600


Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis

Cell Stem Cell. 2009 Jun 5;4(6):559-67.

Hofmann I, Stover EH, Cullen DE, Mao J, Morgan KJ, Lee BH, Kharas MG, Miller PG, Cornejo MG, Okabe R, Armstrong SA, Ghilardi N, Gould S, de Sauvage FJ, McMahon AP, Gilliland DG. Source Division of Hematology, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.


We report the unexpected finding that loss of Hh signaling through conditional deletion of Smoothened (Smo) in the adult hematopoietic compartment has no apparent effect on adult hematopoiesis, including peripheral blood count, number or cell-cycle status of stem or progenitor cells, hematopoietic colony-forming potential, long-term repopulating activity in competitive repopulation assays, or stress response to serial 5-fluorouracil treatment. Furthermore, pharmacologic inhibition of Hh signaling with a potent and selective small molecule antagonist has no substantive effect on hematopoiesis in the mouse. In addition, Hh signaling is not required for the development of MLL-AF9-mediated acute myeloid leukemia (AML). Taken together, these data demonstrate that Hh signaling is dispensable for normal hematopoietic development and hematopoietic stem cell function, indicating that targeting of Hh signaling in solid tumors is not likely to result in hematopoietic toxicity. Furthermore, the Hh pathway may not be a compelling target in certain hematopoietic malignancies.

Comment in Cell Stem Cell. 2009 Jun 5;4(6):470-1.

PMID 19497284


Hox transcription factors and their elusive mammalian gene targets

Heredity. 2006 Aug;97(2):88-96. Epub 2006 May 24.

Svingen T, Tonissen KF. Source Cell Biology Group, Eskitis Institute for Cell and Molecular Therapies and School of Biomolecular and Biomedical Science, Griffith University, Nathan, Queensland 4111, Australia.


The Hox family of homeodomain transcription factors regulate numerous pathways during developmental and normal cellular processes. All Hox proteins recognise similar sequences in vitro yet display functional diversity in an in vivo environment. This review focuses on the transcriptional and functional specificity elicited by Hox proteins, giving an overview of homeodomain-DNA interactions and the gain of binding specificity through cooperative binding with cofactors. Furthermore, currently identified mammalian Hox target genes are presented, of which the most striking feature is that very few direct Hox targets have been identified. The direct targets participate in an array of cellular functions including organogenesis and cellular differentiation, cell adhesion and migration and cell cycle and apoptotic pathways. A further assessment of identified mammalian promoter targets and the contribution of bases outside the canonical recognition motif is given, highlighting roles they may play in either trans-activation or repression by Hox proteins.

PMID 16721389

The list contains likely Hox gene targets and the Hox protein responsible for the trans-regulatory effect. The (+/-) symbols represent either a positive or negative regulatory effect on the target gene and (?) symbol indicates an unknown effect. Also, note that although there is some experimental evidence to suggest all are likely direct gene targets, not all have been exclusively verified of being so through in vivo experiments. The corresponding reference(s) for each gene target is also shown.

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Hox protein






Kutejova et al (2005)


Raman et al (2000a)

HOXA5  Human 
HOXA5+Progesterone receptorHuman

Raman et al (2000b)


Chen et al (2005)


Foucher et al (2002); Gao et al (2002)


Shi et al (1999, 2001)


Bruhl et al (2004)


Bromleigh and Freedman (2000)

HOXA10+ beta 3-IntegrinHuman

Daftary et al (2002)


Troy et al (2003)


Kim et al (2003)

Hoxa13, Hoxd13+EphA7Mouse

Salsi and Zappavigna (2006)


Penkov et al (2000)


Guazzi et al (1994)


Safaei (1997)


Wu et al (2003)


Carè et al (1996)


Jones et al (1992)


Jones et al (1992)


Tomotsune et al (1993)


Tkatchenko et al (2001)

Hoxd10, b6, b7, b9, c8+ReninMouse

Pan et al (2004)


Developmental regulation of the Hox genes during axial morphogenesis in the mouse

Development. 2005 Jul;132(13):2931-42.

Deschamps J, van Nes J. Source Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. jacqueli@niob.knaw.nl


The Hox genes confer positional information to the axial and paraxial tissues as they emerge gradually from the posterior aspect of the vertebrate embryo. Hox genes are sequentially activated in time and space, in a way that reflects their organisation into clusters in the genome. Although this co-linearity of expression of the Hox genes has been conserved during evolution, it is a phenomenon that is still not understood at the molecular level. This review aims to bring together recent findings that have advanced our understanding of the regulation of the Hox genes during mouse embryonic development. In particular, we highlight the integration of these transducers of anteroposterior positional information into the genetic network that drives tissue generation and patterning during axial elongation.

PMID 15944185