Talk:Corpus Luteum Development: Difference between revisions
mNo edit summary |
mNo edit summary |
||
| Line 1: | Line 1: | ||
{{Talk Page}} | {{Talk Page}} | ||
==2018== | ==2018== | ||
==Review - Angiogenesis in the human corpus luteum== | |||
Reprod Med Biol. 2008 Apr 17;7(2):91-103. doi: 10.1111/j.1447-0578.2008.00205.x. eCollection 2008 Jun. | |||
Sugino N1, Matsuoka A1, Taniguchi K1, Tamura H1. | |||
Abstract | |||
Angiogenesis is important for the formation and development of the corpus luteum and for maintenance of luteal function. Blood vessel regression is an important physiological phenomenon in the corpus luteum, which is associated with tissue involution during structural luteolysis. Angiogenesis actively occurs during the early luteal phase and is completed by the mid-luteal phase. Perivascular cells (pericytes) increase in number from the early luteal phase to the mid-luteal phase, suggesting that blood vessels are gradually stabilized until the mid-luteal phase. In the corpus luteum undergoing luteolysis, blood vessels and pericytes decrease in number, which is related to structural involution. In the corpus luteum of early pregnancy, the number of blood vessels with pericytes increases, suggesting that angiogenesis occurs again, accompanied by blood vessel stabilization. These changes in vasculature of the corpus luteum are regulated by the collaboration with vascular endothelial growth factor, which is involved in proliferation of vascular endothelial cells, and angiopoietins, which are involved in stabilization of blood vessels. This review focuses on angiogenesis, blood vessel stabilization and blood vessel regression during the divergent phases of luteal formation, luteal regression and luteal rescue by pregnancy. (Reprod Med Biol 2008; 7: 91-103). | |||
KEYWORDS: | |||
angiogenesis; angiopoietin; blood flow; corpus luteum; vascular endothelial growth factor | |||
PMID: 29699289 PMCID: PMC5904659 DOI: 10.1111/j.1447-0578.2008.00205.x | |||
===MiR-29b affects the secretion of PROG and promotes the proliferation of bovine corpus luteum cells=== | ===MiR-29b affects the secretion of PROG and promotes the proliferation of bovine corpus luteum cells=== | ||
Revision as of 10:15, 6 May 2018
| About Discussion Pages |
|---|
Glossary Links
Cite this page: Hill, M.A. (2024, April 19) Embryology Corpus Luteum Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Corpus_Luteum_Development |
2018
Review - Angiogenesis in the human corpus luteum
Reprod Med Biol. 2008 Apr 17;7(2):91-103. doi: 10.1111/j.1447-0578.2008.00205.x. eCollection 2008 Jun.
Sugino N1, Matsuoka A1, Taniguchi K1, Tamura H1.
Abstract
Angiogenesis is important for the formation and development of the corpus luteum and for maintenance of luteal function. Blood vessel regression is an important physiological phenomenon in the corpus luteum, which is associated with tissue involution during structural luteolysis. Angiogenesis actively occurs during the early luteal phase and is completed by the mid-luteal phase. Perivascular cells (pericytes) increase in number from the early luteal phase to the mid-luteal phase, suggesting that blood vessels are gradually stabilized until the mid-luteal phase. In the corpus luteum undergoing luteolysis, blood vessels and pericytes decrease in number, which is related to structural involution. In the corpus luteum of early pregnancy, the number of blood vessels with pericytes increases, suggesting that angiogenesis occurs again, accompanied by blood vessel stabilization. These changes in vasculature of the corpus luteum are regulated by the collaboration with vascular endothelial growth factor, which is involved in proliferation of vascular endothelial cells, and angiopoietins, which are involved in stabilization of blood vessels. This review focuses on angiogenesis, blood vessel stabilization and blood vessel regression during the divergent phases of luteal formation, luteal regression and luteal rescue by pregnancy. (Reprod Med Biol 2008; 7: 91-103). KEYWORDS: angiogenesis; angiopoietin; blood flow; corpus luteum; vascular endothelial growth factor PMID: 29699289 PMCID: PMC5904659 DOI: 10.1111/j.1447-0578.2008.00205.x
MiR-29b affects the secretion of PROG and promotes the proliferation of bovine corpus luteum cells
PLoS One. 2018 Apr 4;13(4):e0195562. doi: 10.1371/journal.pone.0195562. eCollection 2018.
Xu MQ1, Jiang H1, Zhang LQ2, Sun XL1, Luo D1, Fu Y1, Gao Y1, Yuan B1, Zhang JB1.
Abstract
The regulatory role of miRNAs has been explored in ovarian cells, and their effects on gonadal development, apoptosis, ovulation, steroid production and corpus luteum (CL) development have been revealed. In this study, we analyzed the expression of miR-29b at different stages of bovine CL development and predicted the target genes of miR-29b. We confirmed that miR-29b reduces the expression of the oxytocin receptor (OXTR), affects progesterone (PROG) secretion and regulates the function of the CL. RT-PCR showed that the expression of miR-29b was significantly higher in functional CL phases than in the regressed CL phase. Immunohistochemistry showed that OXTR was expressed in both large and small CL cells and was mainly located in the cell membrane and cytoplasm of these cells. We analyzed the expression levels of OXTR and found that transfection with a miR-29b mimic decreased OXTR expression, but transfection with the inhibitor had a limited effect on the expression of the OXTR protein. At the same time, the secretion of PROG was significantly increased in the miR-29b mimic-transfected group. We also analyzed the effect of miR-29b on the apoptosis of CL cells. Finally, we found that miR-29b could promote the proliferation of bovine CL cells. In conclusion, we found that miR-29b reduces the expression of OXTR and can promote PROG secretion and the proliferation of CL cells via OXTR. PMID: 29617446 PMCID: PMC5884578 DOI: 10.1371/journal.pone.0195562
