From Embryology
Revision as of 20:30, 4 August 2009 by S8600021 (talk | contribs) (New page: == Introduction == Project Concept by Dr Mark Hill, Cell Biology Lab, Department of Anatomy, School of Medical Sciences. This project went online in 1997 and has continued to be updated si...)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)


Project Concept by Dr Mark Hill, Cell Biology Lab, Department of Anatomy, School of Medical Sciences. This project went online in 1997 and has continued to be updated since that time. [About.htm About the Author]


This project is dedicated to Beverley Hill (1933-2001) who from 1996 - 2000 worked patiently on all facets of this project; preparing images, fixing text, links, and committing a tireless labour on my continual updates and changes.

Contributors: [#Dedication Dedication] | [#Serial Serial Images] | [#AnatomyNotes Anatomy Notes] | [#Behringer Richard Behringer] | [#Coombs Peter Coombs] | [#Creteko Chris Creteko] | [#Davidson Lance Davidson] | [#DiMarzo DiMarzo] | [#Diewert Virginia Diewert] | [#Dunwoodie Sally Dunwoodie] | [#Giangrande Angela Giangrande] | [#Haaf Thomas Haaf] | [#Hanauer David Hanauer] | [#Jain Sanjiv Jain] | [#Kageyama Ryoichiro Kageyama] | [#Kirby Margaret Kirby] | [#Kulesa Paul Kulesa] | [#Lancaster Paul Lancaster] | [#Paul_Larsen Paul Larsen] | [#Larsen William Larsen] | [#Molyneaux Kathleen Molyneaux] | [#McLennan Andrew McLennan] | [#Papan Cyrus Papan] | [#Potter Julia Potter] | [#Shiota Kohei Shiota] | [#Stensaas Suzanne Stensaas] | [#Sulik Kathy Sulik] | [#Thomas Charles Thomas] | [#Walsh David Walsh] | [#OnlineContributors Online Contributors] | [#UNSWStudents UNSW Students] | [#UNSWTech UNSW Technical Support] | [#Journal Journals] | [#Glossary Glossary] |

Serial Images History

The original principle of using serial sections on microfiche cards was developed by Dr M. Smith, Prof. C. Watson and the late Prof. I. Tork in the early 1980's. The original 27mm Human embryo microfiche images were developed by Dr M. Smith and the 6mm Pig Embryo microfiche images by Dr M. Smith and Prof. I. Tork.

Anatomy Notes

Anat 2006 Notes are edited with permission of Dr B. Freeman, from his Course Manual for Human Embryology (1995). Other staff and former staff who had contributed to these notes prior to 1989 are Dr M.S.R. Smith, the late Prof. I. Tork, Em. Prof. H.ZawTun, Prof. C.R.R. Watson and Prof. R. Wheeler-Haines.

Notes written and compiled by Dr M. Hill used many different additional texts, research papers and WWW resources. Specific texts are referenced at the top of page 1 in Reading in each section of notes. Otherwise, additional references and WWW resources are acknowledged directly (or the original is accessible) on the specific WWW page.


Thanks to Prof Kohei Shiota for allowing reproduction of material from the Kyoto Collection. (More? [wwwhuman/Stages/Stages.htm Carnegie Stages] | Pubmed search- Shiota, KK)

Thanks to Prof Kathy Sulik for scanning electron micrographs of the Carnegie stages of the early human embryo. Kathy Sulik Homepage | (More? [wwwhuman/Stages/Stagesem.htm Carnegie Stages Electron Micrographs] | [wwwhuman/Stages/Stages.htm Carnegie Stages] Pubmed search- Sulik, KK)

Thanks to Dr SJ DiMarzo, Dr K-F Fischbach, Dr CD Lawrence, and Dr BR Smith who allowed reproduction of their WWW images with permission or as Links back to their original WWW Pages.

Thanks to Prof Paul Lancaster for data published in "Congenital Malformations Australia" Series 1981-92, 1993-94, and 1995-96. (More? [Defect/page3.htm Abnormal Development- Australian Statistics])

Thanks to Dr Paul Kulesa for neural crest migration movies. Paul Kulesa Homepage (More? [Movies/neural.htm#ncrest Neural Crest Development Movies])

Thanks to Dr Margaret Kirby Neonatal Perinatal Research Institute, Duke University Medical Center, for chicken neural crest/heart movies from her supplement to the paper "Time-Lapse Study With High Speed Video Camera in the Early Embryonic Chick Heart to Visualize a Time Window of Normal and Abnormal Heart Development" in Circulation (Email:

Thanks to Dr Andrew McLennan Foetal Medicine Unit, Royal North Shore Hospital for providing foetal ultrasound movies. Dr McLennan 's research interest is in the use of Nuchal translucency screening for chromosomal abnormality in the 1st trimester. (Email: Andrew McLennan)

Thanks to the late Prof William Larsen allowing use of movies from his textbook. (Human Embryology homepage)

Thanks to Prof Kathleen Molyneaux Department of Genetics, Case Western Reserve University for providing mouse primordial germ cell migration movies. (Email: Kathleen Molyneaux)

Thanks to Dr Lance Davidson allowing use of images and movies from his paper. Development Article (Email: Lance Davidson)

Thanks to Dr Thomas Haaf allowing use of his research images on parental genome organization in the preimplantation embryo. (Email: Thomas Haaf)

Thanks to Charles Thomas allowing use of his research images on blastocyst cell division in embryonic c elegans development. (Email: Charles Thomas)

Thanks to Dr David Hanauer for his program "Growth Charts version 1.1" 2003 which is included on the Embryology CD (Email: [ David Hanauer]) Embryology CD Link is in section on postnatal development on the page [Child/page3.htm Normal Development- Postnatal- Growth Charts] - [Child/page3.htm#Growth%20Charts%20Program Growth Charts Program] Note that the program is based on USA Grwth Charts not the new WHO standards. The original program can also be found at (Version 1.2.2

Thanks to Prof Virginia Diewert, Professor of Orthodontics, University of British Columbia, who recently visited the Lab and helped with content, organisation and development of the [Notes/face.htm Face Notes] section. (Email: Virginia Diewert)

Thanks to Prof Richard Behringer and Dr Chris J. Creteko Dept. of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, who provided images and stage information on the embryonic development of the bat. (More? [OtherEmb/bat.htm Other Embryos - Bat]) (Email: Richard Behringer Chris Creteko)

Thanks to Dr Sally Dunwoodie, Developmental Biology Program, Victor Chang Cardiac Research Institute who provided both images and information on (mouse) placental development. (More? [Notes/placenta.htm Placenta Notes]) (Email: Sally Dunwoodie)

Thanks to the late Associate Professor David Walsh, Dept. of Anatomy, University of NSW, who contributed not only a passion to development/teratology research, teaching, collaboration, discussions, and professionally to The Teratology Society, but also a wicked sense of humour and a research scholarship in embryology which bears his name. (More? News Story- The David Walsh Memorial Scholarship | The David Walsh Memorial Scholarship | The Teratology Society)

Thanks to Peter Coombs, Department of Medical Imaging & Radiation Sciences Faculty of Medicine, Nursing & Health Sciences Monash University who provided ultrasound movie on fetal rabbit development. (More? [OtherEmb/rabbit.htm Other Embryos - Rabbit]) (Email: Peter Coombs | Web page)

Thanks to Prof Ryoichiro Kageyama, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan who provided a research movie on mesoderm development. (More? [Movies/mesoderm.htm Movies - Mesoderm]) (Email: Prof R. Kageyama | Lab. of Growth Regulation | Institute for Virus Research)

Thanks to Dr Cyrus Papan, Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos 04-01, Singapore 138669, Singapore who provided magnetic resonance imaging movies on Xenopus blastocyst development. (More? [Movies/MRI.htm Movies - Magnetic Resonance Imaging]) (Email: Cyrus Papan)

Thanks to Professor Julia Potter, Director of Pathology and Dr Sanjiv Jain Director of Anatomical Pathology ACT Government who provided an image of a hydatidiform mole from the ACT Pathology site. (More? [Notes/week2_2.htm#Hydatidiform Notes - Week 2 Abnormalities])

Thanks to Dr Angela Giangrande for glial migration movies from her paper Aigouy B, Lepelletier L, Giangrande A.Glial chain migration requires pioneer cells. J Neurosci. 2008 Nov 5;28(45):11635-41. (More? [Movies/neural.htm Neural Development Movies])

UNSW Students

Thanks also to UNSW students Matthew Chircop, Annu Kumar, John Ozmen who spent some revision hours preparing the labelled microfiche images.

Thanks also to Anthony Tzannes who spent some revision hours preparing clickable links from the microfiche images.

Thanks also to Imran Marzook and Kevin Lee who prepared histology Lab images.

Thanks also to AAshish Kumar an Independent Learning Project (ILP 2006) medical student who prepared 3 dimensional models of the stage 13 and stage 22 embryos. (More? [Movies/3dmodel.htm 3D Models])

UNSW Technical Support

Thanks also to Ted Crawford, Paul Halasz and Craig Howie for their contribution of considerable knowledge of computer systems.

Online Contributors

[#Kimball NCBI] | [#IHM National Library of Medicine] | [#NZNWH NZ National Women's Health] | [#PNAS Proceedings of the The National Academy of Sciences] | [#Gray Anatomy of the Human Body] | [#Blue_Histology UWA - Blue Histology] | [#IMSS Institute and Museum of the History of Science] | [#Manitoba Government of Manitoba Report] | [#Entrez Entrez - 3D macromolecules] | [#EPH Environmental Health Perspectives] | [#PediNeuroLogic PediNeuroLogic Exam] | [#GeneTests GeneTests Web Site] | [#GeneReviews GeneReviews] |

Thanks to Susan Kimball, GenBank User Services, NCBI for permission to use the Public Domain NCBI text. NCBI Homepage

Thanks to Shiva Sabihi for permission to use the Public Domain NHMRC documents.

Thanks to Debra Copeland, for providing fetal heart beat for public use on the Internet Archive

Images from the History of Medicine (IHM) database courtesy of the National Library of Medicine.

Images from NZ National Women's Health courtesy of Newborn Intensive Care teaching resources.

"The Crown copyright protected material may be reproduced free of charge in any format or media without requiring specific permission."

Images from Proceedings of the The National Academy of Sciences are reproduced for educational use.

"Anyone may, without requesting permission, use original figures or tables published in PNAS for noncommercial and educational use (i.e., in a review article, in a book that is not for sale) provided that the original source and copyright notice are cited." (01/07) PNAS - Rights and Permissions | PNAS - current.

Images from Gray's Anatomy of the Human Body (1918) are in the public domain and reproduced for educational use.

(More? Mobile Grays Images).

Thanks to Lutz Slomianka for images from UWA - Blue Histology, copyright Lutz Slomianka 1998-2006.

"The literary and artistic works (excluding the UWA logo) on Blue Histology web-site may be reproduced, adapted, published and distributed for noncommercial purposes. Acknowledgement of the original author in any such reproduction, adaption or publication would be appreciated.

Thanks to Sabina Bernacchini from Institute and Museum of the History of Science (Italy) IMSS for allowing reproduction of selected images from the Surgery and Obstetrics exhibition on this embryology education site. [history/page1770.htm Development History- 1770 - Obstetric Models] | IMSS | IMSS exhibit Room XVIII - Surgery and Obstetrics

Images from Report of the Review and Implementation Committee for The Report of the Manitoba Pediatric Cardiac Surgery Inquest May 2001 showing [Notes/heart2.htm heart abnormalities] courtesy Government of Manitoba (More? Manitoba Health Report).

"Any user of this website may, without charge or request for further permission, reproduce and distribute the Information, or portions of it, for non-profit educational purposes only, provided that the Manitoba government is acknowledged as the source on all reproductions and copies of the Information, and all reproductions and copies contain the Disclaimer Notification and Copyright Notice."

Images of 3D macromolecules from Entrez's 3D-structure database

Chen J, Anderson JB, DeWeese-Scott C, Fedorova ND, Geer LY, He S, Hurwitz DI, Jackson JD, Jacobs AR, Lanczycki CJ, Liebert CA, Liu C, Madej T, Marchler-Bauer A, Marchler GH, Mazumder R, Nikolskaya AN, Rao BS, Panchenko AR, Shoemaker BA, Simonyan V, Song JS, Thiessen PA, Vasudevan S, Wang Y, Yamashita RA, Yin JJ, Bryant SH. MMDB: Entrez's 3D-structure database. Nucleic Acids Res. 2003 Jan 1;31(1):474-7.

Images and data from Environmental Health Perspectives (EPH)

"EHP is a publication of the U.S. government. Publication of EHP lies in the public domain and is therefore without copyright.

Research articles from EHP may be used freely; however, articles from the Environews section of EHP may contain photographs or figures copyrighted by other commercial organizations and individuals that may not be used without obtaining prior approval from both the EHP editors and the holder of the copyright. Use of any materials published in EHP is acknowledged when used ("Reproduced with permission from Environmental Health Perspectives") and provide pertinent reference information for the article from which the material was reproduced. EPH Copyright/Permissions."

Movies from the PediNeuroLogic Exam website are used by permission of Paul D. Larsen, M.D., University of Nebraska Medical Center and Suzanne S. Stensaas, Ph.D., University of Utah School of Medicine. Additional materials were drawn from resources provided by Alejandro Stern, Stern Foundation, Buenos Aires, Argentina; Kathleen Digre, M.D., University of Utah; and Daniel Jacobson, M.D., Marshfield Clinic, Wisconsin. The movies are licensed under a Creative Commons Attribution-Non Commerical-ShareAlike 2.5 License.

Images from the Radiology Cases In Pediatric Emergency Medicine website by Loren Yamamoto, MD, Alson S. Inaba, MD, Robert M. DiMauro, MD Kapiolani Medical Center For Women And Children Dept. Pediatrics, University of Hawaii John A. Burns School of Medicine The original website Radiology Cases In Pediatric Emergency Medicine should always be cited and images are used under the website terms "This is free software. Feel free to distribute this software to others."

GeneTests Web Site/GeneReviews website content used under Terms of Use conditions. "The GeneTests Web site, database, and their contents are copyright protected by the University of Washington, Seattle, 1993-2008. Permission is hereby granted to reproduce, distribute, and translate copies of content materials provided that credit for source ( and copyright (University of Washington, Seattle) are included with each copy and a link to the appropriate material on the GeneTests Web site is provided whenever the material is published elsewhere on the Web."


The following Journals have given permission to reproduce specific journal content on this educational website either under Copyright Clearance application or allow reuse under Creative Commons Attribution License. (Note - the list below is not comprehensive and citations are included on the pages where material is reused, please contact the author directly if this is not found to be the case with any material used on this educational site).

Journals: [#JCB Journal of Cell Biology] | [#JEM Journal of Experimental Medicine] | [#JGM Journal of General Physiology] | [#Nature Nature] | [#PhysiolGenomics Physiol. Genomics] | [#PNAS Proceedings of the National Academy of Sciences USA] | [#PLoS Public Library of Science] | [#Rockefeller Rockefeller University Press] |



Epigenetics: Unfinished symphony | Endothelial tubes assemble from intracellular vacuoles in vivo | Klimanskaya I, Chung Y, Becker S, Lu SJ, Lanza R. Human embryonic stem cell lines derived from single blastomeres. Nature. 2006 Aug 23 [wwwhuman/Stages/Stage3.htm image] copyright |


Physiol. Genomics

Soufan AT, Ruijter JM, van den Hoff MJ, de Boer PA, Hagoort J, Moorman AF. Three-dimensional reconstruction of gene expression patterns during cardiac development. Physiol Genomics. 2003 May 13;13(3):187-95. Review.


Proceedings of the National Academy of Sciences USA (PNAS)

Proceedings of the National Academy of Sciences Homepage


Public Library of Science (PLoS)

Material from the Public Library of Science (PLoS) journals is reproduced under the Creative Commons Attribution License (CCAL), authors retain ownership of the copyright for their article, but authors allow anyone to download, reuse, reprint, modify, distribute, and/or copy articles in PLoS journals, so long as the original authors and source are credited. This broad license was developed to facilitate open access to, and free use of, original works of all types. (More? Open Access License)

[Movies/neural/neuralplate.htm Movie - Movement of Nuclei in Early Stages of Neural Rod Formation] Staudt N, Houart C. The Prethalamus Is Established during Gastrulation and Influences Diencephalic Regionalization. PLoS Biol. 2007 Mar 6;5(4):e69

[Movies/week1/fertilization.htm Movie - In vitro fertilization] Motosugi N, Dietrich JE, Polanski Z, Solter D, Hiiragi T. Space asymmetry directs preferential sperm entry in the absence of polarity in the mouse oocyte. PLoS Biol. 2006 May;4(5):e135.


Rockefeller University Press

"The Rockefeller University Press still derives essential revenue from journal subscriptions to content within the first six months, and thus we cannot risk the creation of a free mirror site during this time. The Creative Commons License will apply retroactively to all work published by The Rockefeller University Press (The Journal of Cell Biology, The Journal of Experimental Medicine, or The Journal of General Physiology) before November 1, 2007. ...Third parties may use our published materials under a Creative Commons license, six months after publication."

Links: Creative Commons | Copyright Clearance Center | JCB Article - You wrote it; you own it! | PubMed - Hill E, Rossner M. You wrote it; you own it! J Cell Biol. 2008 Apr 30.| Journal of Cell Biology |

[Refer/embryo.htm Citations of UNSW Embryology] | [disclaimer.htm Disclaimer]

UNSW Embryology ISBN: 978 0 7334 2609 4

The material is for tutorial/revision purposes and cannot be reproduced electronically or in writing without permission.

Software on the CD version cannot be copied or redistributed.

This program is prepared and distributed for EDUCATIONAL PURPOSES ONLY.

This is a non-profit project and charges reflect COST RECOVERY only.

No warrantee is offered or implied.

UNSW Embryology ISBN: 978 0 7334 2609 4 UNSW CRICOS Provider Code No. 00098G

[About.htm About Author] |Copyright: Dr Mark HillCreated: 01.06.1997Updated: 24.11.2008 UNSW CRICOS Provider Code No. 00098G


This page gives me the pleasant opportunity to thank the many people who have contributed to the development of UNSW Embryology.

Let me first apologise to any contributor I may have missed over the years.

I thank especially, and dedicate this project to, my aunt who worked as a volunteer in my Lab on this project for many years.

New Contributors

If you are an Embryology researcher or educator and would like to contribute to the project please contact me by email.

If you would like to use site content for educational purposes please contact me by email clearly indicating the page and materials requested. No content can be republished on the internet. ([disclaimer.htm Disclaimer])

In all cases contact the original researcher or publisher for permissions concerning content used here from other sources. Citations appear on pages where material appears, additional authors and sources are listed on this current page.

Please email Dr Mark Hill if you wish to make a comment about this current project.