Talk:Carnegie stage 5

Carnegie Collection

5a

8020 8155 8225

5b

8004 8171 8215 9350

5c

4900 Poor 7699 Exc. 7700 Exc. 7770 Exc. 7771 Exc. 7950 Exc. 8000 Poor 8139 Exc. 8299 Exc. 8329 Exc. 8330 Exc. 8370 Poor 8558

SPECIMENS OF STAGE 5a

Carnegie No. 8225

• Described briefly by Hertig and Rock (1945b).
• Hysterectomy (bicornuate uterus).
• Anterior wall of uterus.
• Chorion, 0.33 x 0.306 mm. Chorionic cavity, 0.228 x 0.2 mm. Embryonic disc, 0.09 x 0.078 mm.
• Perhaps more advanced than No. 8020 (Mazanec, 1959; Harris and Ramsey, 1966), but has also been interpreted as less advanced (Hertig, Rock, and Adams, 1956). Photomicrograph in Hertig, Rock, and Adams (1956, fig. 9).
• Presumed age, 7 days.

Carnegie No. 8020

• Described by Hertig and Rock (1945a).
• Hysterectomy.
• Posterior wall of uterus.
• Chorion, 0.45 x 0.3 mm. Chorionic cavity, 0.288 x 0.186 mm. Embryonic disc, 0.126 x 0.092 mm.
• New model of blood vessels at implantation site has been prepared (Harris and Ramsey, 1966).
• Presumed age, 7 days.

Fruhling, Ginglinger, and Gandar (1954) described briefly a specimen of about 8 days. Curettage. Early implantation. Few trophoblastic digitations. Beginning amniotic cavity. Most sections through embryonic disc lost.

(figs. 5-3 to 5-5).

Carnegie No. 8155

• Described by Hertig and Rock (1949).
• Hysterectomy.
• Anterior wall of uterus.
• Chorion, 0.306 x 0.210 mm. Chorionic cavity, 0.168 x 0.082 mm. Em- bryonic disc, 0.09 x 0.05 mm. "Tropho-epiblastic cavity" (Luckett, 1975).

(fig. 14).

SPECIMENS OF STAGE 5b

Carnegie No. 8171

• Described by Hertig and Rock (1949).
• Hysterectomy.
• Posterior wall of uterus.
• Abnormal leucocytic infiltration of endometrium. Chorion, 0.422 x 0.404 mm.
• Chorionic cavity, 0.164 x 0.138 mm. Embryonic disc, 0.114 x 0.088 mm. A cellular remnant within the umbilical vesicle, because it is probably derived from the endoderm, "may, in a sense, be regarded as an abnormal form of twin embryo" (ibid.). Presumed age, 9 days.

Carnegie No. 8215

• Described briefly by Hertig and Rock (1945c).
• Hysterectomy. Posterior wall of uterus.
• Chorion, 0.525 x 0.498 mm. Chorionic cavity, 0.228 x 0.21 mm. Em- bryonic disc, 0.084 x 0.052 mm. Lacunae perhaps further developed than in No. 8171 (Mazanec, 1959), but specimen has been "considered to be slightly younger ... because the decidual reaction is not yet apparent" (Hertig, Rock, and Adams, 1956). Photomicrographs in Hertig, Rock, andAdams (1956, figs. 15 and 17).
• Presumed age, 9 days.

Carnegie No. 8004

• Described by Hertig and Rock (1945a).
• Hysterectomy.
• Posterior wall of uterus.
• Chorion, 0.582 x 0.45 mm. Chorionic cavity, 0.312 x 0.185 mm. Embryonic disc, 0.132 x 0.1 mm.

(figs. 5-7 to 5-9).

Carnegie No. 9350

• Described briefly by Heuser (1956).
• Hysterectomy.
• At junction of posterior and anterior walls. Chorion, 0.59 x 0.58 mm. Chorionic cavity, 0.3 x 0.1 mm. Embryonic disc, 0.132 x 0.09 mm.
• Presumed age, 9 days.

STAGE 5C

Carnegie No. 7699

• Described by Hertig and Rock (1941). Hysterectomy. Posterior wall of uterus. Chorion, 1.026 x 0.713 mm. Chorionic cavity, 0.48 x 0.336 mm. Embryonic disc, 0,138 x 0.138 mm. New model of blood vessels at implantation site has been prepared (Harris and Ramsey, 1966). Presumed age, 11 days.

Carnegie No. 4900

• Miller. Described by Streeter (1926). Curettage Angiogenesis described by Hertig (1935). Incomplete (some sections missing) Primary umbilical vesicle present New graphic reconstruction made by Streeter U939a,b) Chorion, 0 9 mm Chorionic cavity, 0.4 mm.
• Presumed age, 10-11 days or perhaps even 12 days (Krafka, 1941).

Carnegie No. 7950

• Described briefly by Hertig and Rock (1944).
• Chorion, 0.75 x 0.45 mm. Chorionic cavity, 0.4 x 0.26 mm. Embryonic disc, 0.16 x 0.07 mm.
• Slightly more developed than No. 7699, although embryo is a little less differentiated. Photomicrographs in Hertig, Rock, and Adams (1956; figs. 27 and 35). Presumed age, 12 days.

Carnegie No. 7700

• Described by Hertig and Rock (1941).
• Hysterectomy. Posterior wall of uterus. Chorion, 0.948 x 0.835 mm. Chorionic cavity, 0.55 X 0.498 mm. Embryonic disc, 0.204 x 0.165 mm.
• Presumed age, 12 days.

(figs. 18-22)

Carnegie No. 8558

• Measurements and photomicrographs in Hertig, Rock, and Adams (1956; figs. 30 and 37).
• Chorion, 0.96 x 0.52 mm. Chorionic cavity, 0.58 x 0.36 mm. Embryonic disc, 0.22 X 0.08 mm.
• Presumed age, 12 days.

Carnegie No. 8330

• Measurements and photomicrographs in Hertig, Rock, and Adams (1956; figs. 30 and 37).
• Chorion, 0.85 x 0.65 mm. Chorionic cavity, 0.46 x 0.4 mm. Embry- onic disc, 0.216 x 0.063 mm.
• Condensation of extra-embryonic mesoblast perhaps indicates "the beginning of axis formation" (ibid.).
• Presumed age, 12 days.

Carnegie No. 8139

• Described by Marchetti (1945), who admitted that it is "not entirely normal."
• Curettage.
• Chorion, 0.706 x 1.2 mm. Chorionic cavity, 0.635 x 0.582 mm. Embryonic disc, 0.126 x 0.048 x 0.116 mm. Embryo located centrally in chorionic cavity, which contains a meshwork. Embryonic disc, slightly ovoid (i.e., presents a longitudinal axis).
• Described originally as previllous, although "primitive villi" (stage 6) are mentioned by Boyd and Hamilton (1970): folds of undulating contour of cytotrophoblast are not yet "primitive unbranching villi, although they may be the primordia of them" (Marchetti, 1945; fig. 5). Primary umbilical vesicle present. May be regarded as transitional between stages 5 and 6.
• Presumed age, 13 days.