2019
2017
eMed URL Link: http://emed.med.unsw.edu.au/Map.nsf/wFrameset?OpenFrameSet&Frame=NotesView&Src=/Map.nsf/0/159748002E587E4ECA257339000628C9?OpenDocument&Login
Monday 29 May 2017 09:00 AM - 10:00 AM Development of the nervous system Kensington - Rex Vowels Theatre Hill, Mark
Neural groove closing to neural tube, early week 4
(
Stage 10)
Relative brain size embryonic (week 4, 5, 6, and 8) and late fetal (third trimester)
Neuropores
- cranial (anterior) neuropore closes before caudal (posterior)
- failure to close - Neural Tube Defects (NTD), severity dependent upon level, spina bifida anancephaly (More? [neuron2.htm Neural Abnormalities])
- found that supplementation of maternal diet with folate reduces incidence of NTDs
- A randomised controlled trial conducted by the Medical Research Council of the United Kingdom demonstrated a 72% reduction in risk of recurrence by periconceptional (ie before and after conception) folic acid supplementation (4mg daily).
- Women who have one infant with a neural tube defect have a significantly increased risk of recurrence (40-50 per thousand compared with 2 per thousand for all births)
Early Brain Structure
Primary Vesicles
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Secondary Vesicles
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Week 4 - rostral neural tube forms 3 primary brain vesicles
- prosencephalon (forebrain)
- mesencephalon (midbrain)
- rhombencephalon (hindbrain)
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Week 5 - 3 primary vesicles develop to form 5 secondary vesicles
- telencephalon (endbrain, forms cerebral hemispheres)
- diencephalon (between brain, forms optic outgrowth)
- mesencephalon (midbrain)
- metencephalon (behind brain)
- myelencephalon (medulla brain)
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Textbook collapse table
Textbooks
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UNSW Embryology
The Developing Human: Clinically Oriented Embryology
Moore, K.L., Persaud, T.V.N. & Torchia, M.G. (2015). The developing human: clinically oriented embryology (10th ed.). Philadelphia: Saunders. (links only function with UNSW connection)
Larsen's Human Embryology
Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R., Francis-West, P.H. & Philippa H. (2015). Larsen's human embryology (5th ed.). New York; Edinburgh: Churchill Livingstone.(links only function with UNSW connection)
More Textbooks?
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