Talk:BGDA Lecture - Development of the Nervous System: Difference between revisions
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==2019== | |||
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! Iodine deficiency | |||
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| [[Abnormal Development - Iodine Deficiency]] | |||
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! {{ICD-11}} | |||
|-bgcolor="FEF9E7" | |||
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{{ICD11weblink}}900299738 5B5K.3 Iodine deficiency] - ''Iodine deficiency disorders (IDD), caused mainly by a low dietary supply of iodine, refer to all of the consequences of iodine deficiency in a population that can be prevented by ensuring that the population has an adequate intake of iodine. Iodine deficiency is the most frequent cause of preventable brain damage in childhood.'' | |||
{{ICD11weblink}}900488632 5A00.04 Congenital hypothyroidism due to iodine deficiency] - ''Hypothyroidism is a condition which arises at birth where the thyroid gland produces too little or no thyroid hormone and it can be induced by iodine-deficiency.'' | |||
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==2017== | ==2017== | ||
eMed URL Link: http://emed.med.unsw.edu.au/Map.nsf/wFrameset?OpenFrameSet&Frame=NotesView&Src=/Map.nsf/0/159748002E587E4ECA257339000628C9?OpenDocument&Login | eMed URL Link: http://emed.med.unsw.edu.au/Map.nsf/wFrameset?OpenFrameSet&Frame=NotesView&Src=/Map.nsf/0/159748002E587E4ECA257339000628C9?OpenDocument&Login | ||
Monday 29 May 2017 09:00 AM - 10:00 AM Development of the nervous system Kensington - Rex Vowels Theatre Hill, Mark | |||
[[File:Stage10_neural_sm.jpg|thumb|300px|Neural groove closing to neural tube, early week 4 <br>([[Carnegie_stage_10|Stage 10]])]] | |||
[[File:Human brain growth 01.jpg|thumb|300px|alt=Brain size embryonic (week 4, 5, 6, and 8) and late fetal (third trimester)|Relative brain size embryonic (week 4, 5, 6, and 8) and late fetal (third trimester)]] | |||
===Neuropores=== | |||
{| | |||
|- | |||
! Cranial Neuropore | |||
! Caudal Neuropore | |||
|- | |||
| [[File:Stage11 sem9.jpg|200px]] | |||
| [[File:Stage12_SEM3.jpg|200px]] | |||
|- | |||
| ([[Carnegie stage 11|stage 11]]) | |||
| ([[Carnegie stage 12|stage 12]]) | |||
|} | |||
* cranial (anterior) neuropore closes before caudal (posterior) | |||
* failure to close - Neural Tube Defects (NTD), severity dependent upon level, spina bifida anancephaly (More? [neuron2.htm Neural Abnormalities]) | |||
* found that supplementation of maternal diet with folate reduces incidence of NTDs | |||
** A randomised controlled trial conducted by the Medical Research Council of the United Kingdom demonstrated a 72% reduction in risk of recurrence by periconceptional (ie before and after conception) folic acid supplementation (4mg daily). | |||
** Women who have one infant with a neural tube defect have a significantly increased risk of recurrence (40-50 per thousand compared with 2 per thousand for all births) | |||
==Early Brain Structure== | |||
{| | |||
! Primary Vesicles | |||
! Secondary Vesicles | |||
|- | |||
| [[File:CNS primary vesicles.jpg|600px]] | |||
Week 4 - rostral neural tube forms 3 primary brain vesicles | |||
# '''prosencephalon''' (forebrain) | |||
# '''mesencephalon''' (midbrain) | |||
# '''rhombencephalon''' (hindbrain) | |||
| [[File:CNS secondary vesicles.jpg|600px]] | |||
Week 5 - 3 primary vesicles develop to form 5 secondary vesicles | |||
# telencephalon''' (endbrain, forms cerebral hemispheres) | |||
# '''diencephalon''' (between brain, forms optic outgrowth) | |||
# '''mesencephalon''' (midbrain) | |||
# '''metencephalon''' (behind brain) | |||
# '''myelencephalon''' (medulla brain) | |||
|} | |||
===Textbook collapse table=== | ===Textbook collapse table=== |
Latest revision as of 17:37, 25 May 2019
2019
Iodine deficiency | ||
---|---|---|
Abnormal Development - Iodine Deficiency
|
2017
Monday 29 May 2017 09:00 AM - 10:00 AM Development of the nervous system Kensington - Rex Vowels Theatre Hill, Mark
Neuropores
Cranial Neuropore | Caudal Neuropore |
---|---|
(stage 11) | (stage 12) |
- cranial (anterior) neuropore closes before caudal (posterior)
- failure to close - Neural Tube Defects (NTD), severity dependent upon level, spina bifida anancephaly (More? [neuron2.htm Neural Abnormalities])
- found that supplementation of maternal diet with folate reduces incidence of NTDs
- A randomised controlled trial conducted by the Medical Research Council of the United Kingdom demonstrated a 72% reduction in risk of recurrence by periconceptional (ie before and after conception) folic acid supplementation (4mg daily).
- Women who have one infant with a neural tube defect have a significantly increased risk of recurrence (40-50 per thousand compared with 2 per thousand for all births)