Talk:Abnormal Development - Heavy Metals
From Embryology
Embryo toxicity and teratogenicity of formaldehyde. Thrasher JD, Kilburn KH. Arch Environ Health. 2001 Jul-Aug;56(4):300-11. Review. PMID: 11572272
"C-14 formaldehyde crosses the placenta and enters fetal tissues. The incorporated radioactivity is higher in fetal organs (i.e., brain and liver) than in maternal tissues. The incorporation mechanism has not been studied fully, but formaldehyde enters the single-carbon cycle and is incorporated as a methyl group into nucleic acids and proteins. Also, formaldehyde reacts chemically with organic compounds (e.g., deoxyribonucleic acid, nucleosides, nucleotides, proteins, amino acids) by addition and condensation reactions, thus forming adducts and deoxyribonucleic acid-protein crosslinks. "
