Talk:Abnormal Development - Bacterial Infection
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Cite this page: Hill, M.A. (2024, April 25) Embryology Abnormal Development - Bacterial Infection. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Abnormal_Development_-_Bacterial_Infection |
2011
President's commission considers how to protect human rights after Guatemala experiment
BMJ. 2011 May 23;342:d3232. doi: 10.1136/bmj.d3232.
Tanne JH. Source New York. PMID: 21606141
- "The US Presidential Commission for the Study of Bioethical Issues was established in 2009. Since Susan Reverby, a historian from Wellesley College, near Boston, discovered last year that the US Public Health Service had conducted unethical research in Guatemala from 1946 to 1948, the commission has concentrated on protecting the human rights of people in such studies. The commission held its fifth public session in New York on 18 and 19 May and plans to present its report this summer."
- "n the Guatemala studies nearly 700 people were deliberately infected with syphilis and other sexually transmitted diseases in hopes of showing that the new drug penicillin could be used immediately after sex to prevent infection. Among those included in the studies were female sex workers, soldiers, prison inmates, and mental hospital patients. They were not told the study’s purpose and did not give informed consent. The studies were never published. Guatemalan authorities are also conducting their own investigation into what happened."
http://www.ncbi.nlm.nih.gov/pubmed/21606141
http://www.bmj.com/content/342/bmj.d3232.long
2009
Trophoblast infection with Chlamydia pneumoniae and adverse pregnancy outcomes associated with placental dysfunction
Am J Obstet Gynecol. 2009 May;200(5):526.e1-7.
Gomez LM, Parry S.
Maternal and Child Research Program, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Abstract OBJECTIVE: We sought to determine whether Chlamydia pneumoniae impairs invasive trophoblast function and is associated with preeclampsia.
STUDY DESIGN: We conducted cell viability and invasion assays using primary extravillous trophoblast cells isolated from first-trimester placentas. We performed a case-control study to identify C pneumoniae in trophoblast cells dissected by laser capture microscopy from placentas in women with severe preeclampsia and control subjects who delivered at term.
RESULTS: Trophoblast cell viability and invasion through extracellular matrices were decreased after infection with C pneumoniae (both P < .05). C pneumoniae DNA was detected in trophoblast cells in 15/48 cases but only 3/30 controls (odds ratio, 4.1; P = .02). Positive and negative controls yielded expected results.
CONCLUSION: C pneumoniae infection can reduce trophoblast invasion into the uterine wall and is associated with preeclampsia. Further investigation of the mechanisms by which C pneumoniae induces trophoblast dysfunction, and the identification of therapies to prevent adverse outcomes attributed to trophoblast dysfunction, are warranted.
PMID: 19375572 http://www.ncbi.nlm.nih.gov/pubmed/19375572
WWW Links
CDC (USA)
Public Health Training Network Epidemiology and Prevention of Vaccine-Preventable Diseases (viewable Webcasts requires Media Player) |
Advisory Committee on Immunization Practices (ACIP) Recommendations
Royal College of Obstetricians and Gynaecologists (UK)
Infection and Pregnancy - study group recommendations (Jun 2001)
References
Links: [#PubMedReviews Reviews] | [#PubMedArticles Articles] | [#OnlineTextbooks Online Textbooks] | [#SearchTextbooks Search Textbooks] | [#SearchPubMed Search PubMed] | [#Glossary Glossary]
Reviews
Donders GG. Management of genital infections in pregnant women. Curr Opin Infect Dis. 2006 Feb;19(1):55-61.
Goodnight WH, Soper DE. Pneumonia in pregnancy. Crit Care Med. 2005 Oct;33(10 Suppl):S390-7.
Boggess KA. Pathophysiology of preterm birth: emerging concepts of maternal infection. Clin Perinatol. 2005 Sep;32(3):561-9.
Hirsch E, Wang H. The molecular pathophysiology of bacterially induced preterm labor: insights from the murine model. J Soc Gynecol Investig. 2005 Apr;12(3):145-55.
Berman SM. Maternal syphilis: pathophysiology and treatment. Bull World Health Organ. 2004 Jun;82(6):433-8.
Doganay M. Listeriosis: clinical presentation. FEMS Immunol Med Microbiol. 2003 Apr 1;35(3):173-5.
Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med. 2000 May 18;342(20):1500-7.
Ross SM. Sexually transmitted diseases in pregnancy. Clin Obstet Gynaecol. 1982 Dec;9(3):565-92.
Articles
Guerra B, Ghi T, Quarta S, Morselli-Labate AM, Lazzarotto T, Pilu G, Rizzo N. Pregnancy outcome after early detection of bacterial vaginosis. Eur J Obstet Gynecol Reprod Biol. 2006 Sep-Oct;128(1-2):40-5. Epub 2006 Feb 3.
Giuliani MM, Adu-Bobie J, Comanducci M, Arico B, Savino S, Santini L, Brunelli B, Bambini S, Biolchi A, Capecchi B, Cartocci E, Ciucchi L, Di Marcello F, Ferlicca F, Galli B, Luzzi E, Masignani V, Serruto D, Veggi D, Contorni M, Morandi M, Bartalesi A, Cinotti V, Mannucci D, Titta F, Ovidi E, Welsch JA, Granoff D, Rappuoli R, Pizza M. A universal vaccine for serogroup B meningococcus. Proc Natl Acad Sci U S A. 2006 Jul 6; [Epub ahead of print]
Colombo DF, Lew JL, Pedersen CA, Johnson JR, Fan-Havard P. Optimal timing of ampicillin administration to pregnant women for establishing bactericidal levels in the prophylaxis of Group B Streptococcus. Am J Obstet Gynecol. 2006 Feb;194(2):466-70.
Bakardjiev AI, Stacy BA, Portnoy DA. Growth of Listeria monocytogenes in the guinea pig placenta and role of cell-to-cell spread in fetal infection. J Infect Dis. 2005 Jun 1;191(11):1889-97.
Goffinet F, Maillard F, Mihoubi N, Kayem G, Papiernik E, Cabrol D, Paul G. Bacterial vaginosis: prevalence and predictive value for premature delivery and neonatal infection in women with preterm labour and intact membranes. Eur J Obstet Gynecol Reprod Biol. 2003 Jun 10;108(2):146-51.
Morley SL, Cole MJ, Ison CA, Camaraza MA, Sotolongo F, Anwar N, Cuevas I, Carbonero M, Campa HC, Sierra G, Levin M. Immunogenicity of a serogroup B meningococcal vaccine against multiple Neisseria meningitidis strains in infants. Pediatr Infect Dis J. 2001 Nov;20(11):1054-61.
Nowicki S, Selvarangan R, Anderson G. Experimental transmission of Neisseria gonorrhoeae from pregnant rat to fetus. Infect Immun. 1999 Sep;67(9):4974-6.
Search PubMed
Search Jan2006 "bacterial infection" 547,445 reference articles of which 45,020 were reviews.
Search PubMed: term = bacterial infection
