Talk:2018 Group Project 3
|Projects 2018: 1 Adrenal Medulla | 3 Melanocytes | 4 Cardiac | 5 Dorsal Root Ganglion|
About this Discussion Page
The project discussion page is where your group members can post discussion on the project topic. This will be demonstrated in the practical tutorial in week 3.
Please follow these 3 simple rules:
- Never identify yourself or any other students by name, use only your student number.
- Only edit your own student page or your own group project page.
- Only add content that is both correctly cited and you have permission to reuse.
|Group Assessment Criteria|
| Science Student Projects
|More Information on Assessment Criteria | Science Student Projects|
<gallery> File:Melanocyte1.jpg|Fig 1 epidermal melanocyte File:Trunk Neural Crest and its migration pathways.png|Fig 2 neural crest migration pathways File:Melanocyte Pathway.gif|Fig 3 melanocyte lineage File:Skin_Melanocytes.jpg|Fig 4 skin epidermis melanocyte File:Hair Follicle.jpg|Fig 5 hair follicle File:Stria Vascularis diagram 2.jpeg|Fig 6 Stria Vascularis File:Left and Right Cochlea.jpeg|Fig 7 Cochlea File:Melanocytes in Eyes of B6 and ep Mice.jpeg|Fig 8 Pigmentation eyes File:Cardiac melanocyte in an embryonic mouse pup.png|Fig 9 cardiac melanocyte File:Meninges of the central nervous system.png|Fig 10 meninges File:Wnt_signalling.jpg|Fig 11 Wnt signalling File:Zebrafish_Melanoma.jpeg|Fig 12 Neural crest reporter File:GEM.jpeg|Fig 13 genetically engineered mice File:IPSC Formation.gif|Fig 14 melanocytes from human iPSCs File:Leopard syndrome skin appearance.jpeg|Fig 15 Lentigine skin File:Mixed_melasma.jpg|Fig 16 Mixed facial melasma File:Common_Vitiligo.jpg|Fig 17 Depigmentation in Vitiligo File:Uveal Melanoma.gif|Fig 18 Ciliochoroidal melanoma in eye File:Oculocutaneous_albinism_eyes.jpg|Fig 19 OCA1A patient eyes <gallery>
Development from neural crest
Areas found: eyes ears heart central nervous system meninges
Problems: Hearing Melanoma vision
development time course
glossary - useful when you have lots of acronyms. Be brief and clear ref. list - generates itself as long as you ref. properly
needs to be explained to another uni student that doesn’t know anything about neural crest and its differentiation.
Key things to understand on what makes a good project page: -Content -Brevity and balance between text and images - it’s an online resource, not a textbook. BALANCE CONTENT. -can have numbered lists and bullet points but don’t turn whole project into this.
If you can’t publish an image directly, you can redraw it and credit it to the article.
- differentiation ho they get to different parts of the body where the local singals come from etc pigmentation and vitamin D
Assessment - Peer Review
Z5229185 (talk) 17:55, 4 October 2018 (AEST) Introduction seems to be too detailed and the linkage to neural crest cells was not mentioned in the introduction. I believe that the focus of the introduction should be shifted more towards the role of neural crest cells in melanocyte formation and not purely on the melanoycytes.
The first sentence of the history sections may need a bit of rephrasing "The history of the discovery of the melanocyte spans about 4000 years, from when a pigmentation disorder of skin was first documented in 2200 BC, to when the melanocyte was confirmed as a pigment synthesising cell in 1917" as it sounds as if the discovery of melanocyte stopped at 1917?
Under the "Skin" section, the 2nd paragraph started off with "we". You may want to tweak this.
Loads of images were uploaded on this wiki page which makes the reading and understanding much easier, good job on this! For the formating, you may consider shifting some images to the sides to make it look better as I think there are way too many images that were placed in the middle of the page for now.
Lots of references were included for what was written so far showing that a lot of research have been done on this topic by this group, good job!
History of research is short, notes a few important researchers, lacks when melanocytes were connected to neural crest derivatives. It also lacks the knowledge of the role melanocytes play in human physiology and how that has changed, connection to Vitamin D synthesis and the history of the role melanocytes play in pathology could also be added.
Tissue Organ Structure and Function - Skin is completely missing, no images or text to be seen. Ear is well explained both in writing and images, understanding of chemical mediation in the adult has been elucidated, no reference to physiological role of the ear and how it achieves it, it would not have to be long. Figure 2 refers to Wv/Wv mutant, what is a Wv/Wv mutant? There is no explanation of this mutant model, whether it is in humans or animals, or why it is important etc. Eyes section notes the combined role of neural-crest derived cells and neuroepithelium of optic cup, explains the layers of the eye nicely within the associated image of Figure 4, which has been correctly formatted and cited. The heart section simply shows an image of a cardiac melanocyte, there should be more here. The CNS topic is short, but it does note the understanding of a role of melanocytes in CNS, but nothing more about how neural crest cells help with giving melanocytes to the CNS, the image is a nice overview of the skull and layers of the scalp.
Embryonic origins, Developmental time course and Molecular Mechanisms / Factors / Genes are all blank, with no images to be seen.
Reference to a mouse model can be seen in the Animal models section, are there other models in other species of mouse mutant that can observe melanocyte embryology? Mention of the melanoma model of genetically-engineered mice is good, but how does it relate to neural crest abnormality?
Current Research explains 2 new systems to observe melanocytes, this section could show findings and how they're important - could be longer. Abnormalities listed are short, some missing entirely, more focus on which are more common could be longer. Abnormalities listed are short, some missing entirely, more focus on which are more common could be noted due to the vast nature of melanocytes. Glossary is nice but incomplete, and there are a sufficient number of references.
Z5091101 (talk) 20:07, 3 October 2018 (AEST)z5091101Z5091101 (talk) 20:07, 3 October 2018 (AEST) Peer review: Hello. I have had a look at your project and it seems your group is doing really well overall. There seems to be some missing information on the skin, I assume you are still researching that and collating your information. The use of images throughout is excellent, all your images are properly referenced and a good example to learn from. I cannot really suggest anything at this point apart from to keep researching and get going with the missing sections.
Wow, I can tell all of you have put in a lot of time researching this project has loads of information and all of the sections that are filled transition well. Other than what I assume you already know as some sections are missing information an I'm sure your group will have those filled out as the semester ends. Melanocyte group I have small changes to make. One this is just personal opinion I feel that for the figures under sections eyes and heart should be right justified and the wording should be on the left instead of the pictures being in the middle of the page. Sections such as developmental time course and mechanisms will have information in the future I assume, the project is well put together without those sections included. The current research section about pluripotent stem cells could be researched a bit more as I feel it is lacking infromation. Maybe give details on how the process is actually done and how pluripotent stem cells are obtained or more infromation on the overiview of the topic that goes a little more in depth analysis. other than those small edits your group is doing an outstanding job this semester.
The introduction is good, however it may be helpful to mention more the embryonic development and an outline of what is going to be talked about. There are good subheadings, some need some content though. The division throughout the page of ears and eyes etc. is very clear. A short paragraph at the start of adult structure and function to tie it together (also in abnormalities, in case there are any in common). The pictures are helpful and assist understanding. There are a few formatting issues to clear up once the content is sorted. The references are looking good and there is evidence of a lot of research. The information so far is interesting, easy to follow and understand.
Z5112688 (talk) Structurally, there is good use of subheadings and images in the former parts of the project. Good introduction, though would be better if the embryonic development is covered a little more. History seems to have been glossed over. Maybe a timeline would better represent the information in the history section. Tissue and organ structure and function section contains clear and concise information. Good use of diagrams as a visual stimulus and the functions are explicitly stated. Developmental time course and molecular mechanisms/ factors/ genes have yet to be explained/ answered. Animal models section has some interesting information on genetically modified mice. Information found in research is stated. Although the information is interesting, it feels like there needs to be a little more explanation on the purpose of the experiments and how their findings help the scientific community. The current research section includes some form of research done. The research should be further explained as to maybe the methodology of their research or the particular result they intend to find at the end of the study. The abnormalities section has a few sections still unanswered. You mentioned varying forms of Waardenburg syndrome, maybe mention the different forms that occur. You did however explain the causes of the varying forms.
Overall I think your project is in good shape. Your formatting is consistent and appropriate, you included a significant amount depth and detail in your information, and you included many helpful diagrams and pictures with information that benefited from clarification. I do not have as much feedback for your group though since even though the current information that is present is great, there are still many sections that lack information or require more detail.
For your introduction, it seems almost like you tried to put your entire project into that one section. You repeat a lot of the information that you presented briefly in your introduction later in other sections. Even though I don't think including information that you are going to discuss in more detail later in the introduction is necessarily a poor choice, I do think that in its current state it seems a little jumbled and there's too much information packed into one paragraph.
Your Tissue/Organ Structure section is well formatted for your information, but some of your pictures don't have correctly formatted descriptions. Furthermore, there is a clear disparity in how much information you include in each of the sections, specifically I think the heart section needs at least a paragraph of information in order for it to match the strength of the other sections. I liked how you continued this formatting style of separating each structure under the Abnormalities section.
The Embryonic Origins section is currently very basic, but it sounds like the right information is currently there, but more detail and subheadings are required in order to convey it.
There is no information under Development Time Course or Molecular Mechanisms/ Factors/ Genes sections, so I cannot give any feedback.
Your Animal Model section seems to include a lot of important and detailed information, but I do think some more information about the fish model needs to be included since currently there is only a picture of a fish without any clarification.
In your Current Research section, you discuss a few important developing methods of research on melanocytes, but I think it would help readers understand these methods more readily if you included specific examples of research studies that employ these methods and what results they found.
Z5229431 (talk) 17:03, 8 October 2018 (AEDT) The organisation of the project is concise yet informative for someone who wishes to know more about melanocytes and their embryonic development. The illustrations are strategically placed to allow easier understanding of the content elaborated. The transition between each paragraph is smooth and is able to sustain the interest of the readers well. There are not much issues with regards to the referencing of your sources but it would be good to align the images to either side of the page so that it is easier for readers to relate the content to the illustrations.
The content in the "Introduction", "History" and "Tissue Organ Structure and Function" sections are well developed and display great understanding of the topic. I love how the content is further divided into smaller subheadings under the "Tissue Organ Structure and Function" section as it helps readers to compare and contrast the origins and function of the melanosomes in each organ described. Perhaps more content can be supplemented under the "Heart" subsection, such as its function and purpose.
Content listed in the "Embryonic Origins" section seems to be substantial but it would be good to include either a diagram or a timeline (or if possible, both) to illustrate the developmental process right from the pluripotent cells in the neural crest into the subsequent melanocytes found in the ears, eyes, skin and leptomeninges. It would be good to include any pathway involved in the developmental process as well. The content under the subsection "Cochlear melanocytes of the inner ear" appears to be incomplete and it would be good to elaborate on the eyes and skin as well since it was previously mentioned earlier in the page.
The "development time course" section can be merged together with the "Embryonic Origin" to make the content more coherent. More content can be added into the "Molecular Mechanisms/ Factors/ Genes" section, probably a summary of the signalling pathway for differentiation of melanocytes as well as the main transcription/growth factors involved. Other animal models studied can also be included if relevant, as it will complement the content listed under the "Animal Models" section. The image (Figure 4) appears to be disconnected with the information about animal models and it would be good to further elaborate on the relevance of the image to the content stated under this subheading.
There seems to be some incomplete content under the "Abnormalities" section which requires some touching up and expansion. Apart from that, the overall progress of the page seems promising! Keep up the good work!
The history provided a good background of Melanocytes and also the idea of Melanocytes being linked to neural crest cells. For Tissue Organ Structure and Function, it is well-organized into sub-parts such as Skin, Ears and Eyes etc. This allows readers to better understand how Melanocytes can be found in different organs and also their different specific function in each organ.
However, the project mostly describes about Melanocytes and its specific functions in each body part, but not much on neural crest and its relevance is being discussed under Embryonic Origins, which should be the main focus of the project.
Sections such as Development Time Course, Molecular Mechanisms/ Factors/ Genes, Abnormalities, Skin, Ears, Heart and CNS are lacking content and need to be worked on.
Overall, the function and application of Melanocytes were well-explained. However, there was not much content on how neural crest development leads to the Melanocytes being formed and its significance. Perhaps the group might want to elaborate and expand more on the Embryonic Origins section. Otherwise, the other parts of the project are understandable and done pretty well!
The introduction is off to a great start with the information it has so far , it would be helpful to also mention the neural crest contribution as well so that it includes every aspect of the project.
The history section is great it contains good information and a easy to follow time course about the discovery of melanocytes .It is a bit brief and could use a little more information .
For the tissue structure and function there seems to bit alot of excess information that is not only about the structure and function of the skin however the overall of this section is clear and has a good amount of relevant information. The visuals are also great to have !
For embryonic origins it starts with as mentioned earlier when all the information on embryonic origin should be confined to this section for clarity purposes. It also seems unfinished as there is very little information.However the information that is provided is well presented and relevant.
From this point on there are alot of sections with little to no information , the abnormalities section for what it does have is off to a good start as well as the current research , advice will be to make sure the content stays relevant to the section and goodluck!
- MelaFind MELASciences (2012, March 10) From Melanocyte to Melanoma [Video file]. Retrieved from https://www.youtube.com/watch?v=aiARvdeXdKM