Talk:2016 Group Project 3: Difference between revisions

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[[User:Z5015544|Z5015544]] ([[User talk:Z5015544|talk]]) 14:31, 16 September 2016 (AEST)Hey guys, here is the link for omim. Type in the name of the gene and it will give you different articles about it: http://www.omim.org/[[User:Z5015544|Z5015544]] ([[User talk:Z5015544|talk]]) 14:31, 16 September 2016 (AEST)
[[User:Z5015544|Z5015544]] ([[User talk:Z5015544|talk]]) 14:31, 16 September 2016 (AEST)Hey guys, here is the link for omim. Type in the name of the gene and it will give you different articles about it: http://www.omim.org/[[User:Z5015544|Z5015544]] ([[User talk:Z5015544|talk]]) 14:31, 16 September 2016 (AEST)
[[User:Z5015544|Z5015544]] ([[User talk:Z5015544|talk]]) 14:41, 16 September 2016 (AEST)Things to include: Flow diagram of the FGFR pathway, 3D diagram of the FGF protein (can be hand-drawn)[[User:Z5015544|Z5015544]] ([[User talk:Z5015544|talk]]) 14:41, 16 September 2016 (AEST)

Revision as of 15:41, 16 September 2016

Group Assessment Criteria  
Mark Hill.jpg Science Student Projects
  1. The key points relating to the topic that your group allocated are clearly described.
  2. The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  3. Content is correctly cited and referenced.
  4. The wiki has an element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  5. Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  6. Relates the topic and content of the Wiki entry to learning aims of embryology.
  7. Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer's wiki.
  8. Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  9. The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  10. Develops and edits the wiki entries in accordance with the above guidelines.
More Information on Assessment Criteria | Science Student Projects
Signalling: 1 Wnt | 2 Notch | 3 FGF Receptor | 4 Hedgehog | 5 T-box | 6 TGF-Beta
Here are some starting places for the topic. Can be patterning, differentiation, etc. as long as a developmental signal process/pathway.


Comments by Group 3

Z5015686 (talk) 12:36, 19 August 2016 (AEST) I thought looking into how prenatal cannabis exposure influences signalling during development might be interesting

Z5017002 (talk) 12:47, 19 August 2016 (AEST) Ooh cool idea, I agree that looks really interesting, there seems to be a lot of literature about its influence on brain development

Z5015544 (talk)z5015544Z5015544 (talk) Thats excellent, what about the sonic hedgehog pathway?

Z5015544 (talk)Other ideasZ5015544 (talk) WNT Signaling Pathway is another one to look at

How can we harvest stem cells from the embyro for use in later life - z5015337

Z5015544 (talk)z5015544Z5015544 (talk) Ok guys I created a couple of subheadings and provided a brief history. Make sure to use primary research articles that are peer-reviewed because I just spoke to Dr Hill and noticed he stressed that a lot.

Z5015337 (talk) I have scoured through the projects of old to get a better idea about what is expected from us for this project - Z5015337 (talk)

Z5015337 (talk)I found this giant slab of text regarding the structures of the receptors involved from a journal article and I am working through culling it down for a usable structure definition: FGF receptors and FGF signal transduction. FGFRs are modular proteins comprising 3 immunoglobulin domains (IgI, IgII and IgIII). IgI and IgII are separated by an acidic box (AD). IgII contains a heparin binding domain (HBD). The IgIII domain is followed by a unique transmembrane (TM), a juxtamembrane (JM) and a kinase domain (KD) interrupted by an interkinase domain (IKD). FGF ligands linked to heparin sulfate proteoglycan (HSPG) bind to IgII and IgIII of FGFR. This results in the dimerization and the subsequent transactivation by phosphorylation of specific tyrosine residues. The main two transduction pathways involve the phospholipase C-γ (PLCγ) and the Ras/MAP kinase. The SH2 domain of the PLCγ interacts with the phosphorylated Y766 of the activated receptor. The activated PLCγ hydrolyzes the phosphatidyl-inositol-4,5-diphosphate (PIP2) to inositol-1,4,5-triphophate (IP3) and the diacylglycerol (DAG). IP3 releases Ca2+ while DAG activates the protein kinase C-δ (PKCδ). Activated PKCδ activates Raf by phosphorylating its S338 and stimulates the downstream pathway in a Ras independent manner. The main pathway involves the interaction of the docking protein FRS2α with the amino-acid residues 407–433 (Xu et al., 1998). This protein is activated by phosphorylation on multiple tyrosine residues and subsequently interacts and activates Grb2 linked to Sos, a nucleotide exchange factor involved in the activation of Ras. Activated Ras then activates Raf which stimulates MEK which in turn phosphorylates the MAP kinase ERK. This last activated component translocates to the nucleus and phosphorylates specific transcription factors of the Ets family which in turn activate expression of specific FGF target genes. P: phosphorylation

Z5015686 (talk) 18:31, 14 September 2016 (AEST) Hey guys I've just changed our subheadings so we can better allocate something for each of us to write on this week. More then happy to change them! Just came across these while I was researching. Did everyone maybe want to put their name next to something they are able to research or chuck in new subheadings that interest them?

Z5015544 (talk) 14:31, 16 September 2016 (AEST)Hey guys, here is the link for omim. Type in the name of the gene and it will give you different articles about it: http://www.omim.org/Z5015544 (talk) 14:31, 16 September 2016 (AEST)

Z5015544 (talk) 14:41, 16 September 2016 (AEST)Things to include: Flow diagram of the FGFR pathway, 3D diagram of the FGF protein (can be hand-drawn)Z5015544 (talk) 14:41, 16 September 2016 (AEST)